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The role of epigenetic mechanisms in autoimmune disease is only now starting to become clear. Understanding these mechanisms, their effect on cellular function and the role of environmental factors is vital to determining how to manage these often debilitating and fatal diseases. Drawing on the research of leading experts, this book provides a valuable insight into this important new area of autoimmunity research and a clear, up-to-date view on the major advances in the field. Specific coverage includes: * How highly developed epigenetic mechanisms are involved in several aspects of normal…mehr

Produktbeschreibung
The role of epigenetic mechanisms in autoimmune disease is only now starting to become clear. Understanding these mechanisms, their effect on cellular function and the role of environmental factors is vital to determining how to manage these often debilitating and fatal diseases. Drawing on the research of leading experts, this book provides a valuable insight into this important new area of autoimmunity research and a clear, up-to-date view on the major advances in the field. Specific coverage includes: * How highly developed epigenetic mechanisms are involved in several aspects of normal immune regulation, in addition to maintaining immune tolerance to self-determinants. * Specific epigenetic aspects of human autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, autoimmune diabetes, thyroid autoimmunity, inflammatory bowel disease and autoimmune hepatitis. * How understanding epigenetic mechanisms can lead to therapeutic strategies based on manipulation of this previously unexploited facet of immune regulation. * Discussion of the novel approaches that are being investigated to prevent or treat autoimmune diseases. This book is an essential resource for those actively involved in the field. It is also of interest to basic researchers interested in understanding the origin of autoimmunity and clinical specialists interested in gaining in-depth understanding of the pathogenesis of autoimmune diseases and their treatment.
  • Produktdetails
  • Verlag: John Wiley & Sons / WILEY
  • Artikelnr. des Verlages: 14575861000
  • New
  • Seitenzahl: 472
  • Erscheinungstermin: Oktober 2009
  • Englisch
  • Abmessung: 253mm x 176mm x 38mm
  • Gewicht: 964g
  • ISBN-13: 9780470758618
  • ISBN-10: 0470758619
  • Artikelnr.: 26051863
Inhaltsangabe
Contributors. PART I: TRANSCRIPTION FACTORS: PARTNERS OF IMMUNE TOLERANCE TO SELF. 1. Transcriptional Regulation of T Cell Tolerance (Brian T. Abe
Ayana Jordan
Vanessa M. Hubbard and Fernando Macian). References. 2. Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells (Julia K. Polansky
Stefan Floess
Jennifer Freyer
Alf Hamann and Jochen Huehn). References. 3. The Role of NF-8B in Central Tolerance (Mingzhao Zhu
Matthew Ruddy and Yang-Xin Fu). References. 4. The Role of Act1 in the Control of Autoimmunity (Trine N. Jörgensen
Natalia V. Giltiay
Angela Johnson and Xiaoxia Li). References. 5. Regulation of T Cell Anergy and Escape from Regulatory T Cell Suppression by Cbl-b (Stefanie Loeser and Josef M. Penninger). References. 6. Indoleamine 2
3-dioxygenase: Transcriptional Regulation and Autoimmunity (Maria Laura Belladonna
Ciriana Orabona
Claudia Volpi
Ursula Grohmann
Paolo Puccetti and Maria Cristina Fioretti). References. PART II: STRESS RESPONSES THAT BREAK IMMUNE SILENCE. 7. Chromatin Modifications
Oxidative Stress and Nucleosome Autoantibodies (Annika Erbacher and Patrice Decker). References. 8. Stress
Epigenetics and Thyroid Autoimmunity (Agathocles Tsatsoulis). References. 9. Reactive Intermediates
Inflammation and Epigenetics in Lupus (Gary S. Gilkeson and Jim C. Oates). References. 10. Post-translational Modification of HMGB1 and Its Role in Immune Activation (Anirudh J. Ullal and David S. Pisetsky). References. 11. Idiosyncratic Drug-Induced Liver Injury: Facts and Perspectives (Jos
. V. Castell and Isabel Miñana). References. PART III: EPIGENETIC MODIFIERS OF AUTOIMMUNITY. 12 Epigenetic Modifications Associated with T Cell Tolerance (Andrew D. Wells and Rajan M. Thomas). References. 13. DNA Methylation Alterations in Systemic Lupus Erythematosus (Biola M. Javierre
Manel Esteller and Esteban Ballestar). References. 14 Long-Range Histone Acetylation Patterns in the Development of Autoimmunity (Thomas M. Aune
Shaojing Chang and Weisong Zhou). References. 15. Roquin Defects Reveal a Role for the microRNA Machinery in Regulating Autoimmunity (Di Yu and Carola G. Vinuesa). References. 16. Autoimmune Response to Post-translationally Modified (Citrullinated) Proteins: Prime Suspect in the Pathophysiology of Rheumatoid Arthritis (Mireille Sebbag
Cyril Clavel
Leonor Nogueira
Jacques Arnaud and Guy Serre). References. 17. Hormones: Epigenetic Contributors to Gender-Biased Autoimmunity (Virginia Rider and Nabih I. Abdou). References. 18. Epigenetics and Systemic Sclerosis (Serena Guiducci and Marco Matucci Cerinic). References. 19. Epigenetic Regulation of B Lymphocyte Development and Repertoire Selection: Relevance to Autoimmunity (Moncef Zouali). References. PART IV: TOWARDS NOVEL EPIGENETIC-BASED IMMUNO-INTERVENTION STRATEGIES IN AUTOIMMUNE DISEASE. 20. Protective Effects of Epigenetic Modifications in Experimental Inflammatory Bowel Disease (Rainer Glauben
Elena Sonnenberg and Britta Siegmund). References. 21. Epigenetic Regulation of Autoimmune Diseases through Deacetylase Inhibition (Bin Li
Yuan Shen
Zhaocai Zhou
Xiaomin Song
Kathryn Bembas
Xiao Yun Zhao
Zheng Cai
Alan Berezov
Sandra J. Saouaf
Hongtao Zhang
Qiang Wang and Mark I. Greene). References. 22. Histone Deacetylases and Autoimmunity (András Treszl
GergQ Mészáros
Gergely Toldi and Barna Vásárhelyi). References. 23. Histone Deacetylase Inhibitors as a Therapeutic Modality in Multiple Sclerosis (Steven G. Gray). References. Index.