Leading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence. Current consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. After dramatic advances in genome sequencing, never before have we known so much about the individual cancer cell--and yet never before has it been so unclear what to do with this knowledge. In this volume, leading researchers argue for a new theory framework for understanding and treating cancer. The contributors propose a complex systems view…mehr
Leading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence. Current consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. After dramatic advances in genome sequencing, never before have we known so much about the individual cancer cell--and yet never before has it been so unclear what to do with this knowledge. In this volume, leading researchers argue for a new theory framework for understanding and treating cancer. The contributors propose a complex systems view of cancer, presenting conceptual building blocks for a new research paradigm supported by empirical evidence.
edited by Bernhard Strauss, Marta Bertolaso, Ingemar Ernberg, and Mina J. Bissell
Inhaltsangabe
Series Foreword ix Preface xi 1 Introduction and Overview 1 I REDEFINING THE PROBLEM: THE THEORY DIMENSION OF CANCER 11 2 The Search for Progress and a New Theory Framework in Cancer Research 13 3 Cancer as a System: Hard Lessons from Physics and a Way Forward 41 II THE SYSTEMS DIMENSION OF CANCER 61 4 The Logic of Cancer Treatment: Why It Is So Hard to Cure Cancer; Treatment-Induced Progression, Hyper-Progression, and the Nietzsche Effect 63 5 The Cell Attractor Concept as a Tool to Advance Our Understanding of Cancer 129 6 Adaptation of Molecular Interaction Networks in Cancer Cells 141 7 The Role of Genomic Dark Matter in Cancer: Using AI to Shine a Light on It; Why Cancer Genes Are Not the Whole Story 163 III THE TIME DIMENSION OF CANCER 185 8 Darwinism, Not Mutationalism, for New Cancer Therapies 187 9 Cancer as a Reversion to an Ancestral Phenotype 205 10 Time and Timing in Oncology: What Therapy Scheduling Can Teach Us about Cancer Biology 227 IV THE MICRO-/ENVIRONMENT DIMENSION OF CANCER 245 11 Tissue Tension Modulates Metabolism and Chromatin Organization to Promote Malignancy 247 12 Cancer Metabolism and Therapeutic Perspectives: Exploiting Acidic, Nutritional, and Oxidative Stresses 271 13 Corrupted Vascular Tumor Niches Confer Aggressiveness and Chemoresistance to Neoplastic Cells 299 14 Metastasis as a Tug of War between Cell Autonomy and Microenvironmental Control: Readdressing Unresolved Questions in Cancer Metastasis 323 15 Niche Reconstruction to Revert or Transcend the Cancer State 353 V WHAT NEXT? 391 Contributors 397 Index 399
Series Foreword ix Preface xi 1 Introduction and Overview 1 I REDEFINING THE PROBLEM: THE THEORY DIMENSION OF CANCER 11 2 The Search for Progress and a New Theory Framework in Cancer Research 13 3 Cancer as a System: Hard Lessons from Physics and a Way Forward 41 II THE SYSTEMS DIMENSION OF CANCER 61 4 The Logic of Cancer Treatment: Why It Is So Hard to Cure Cancer; Treatment-Induced Progression, Hyper-Progression, and the Nietzsche Effect 63 5 The Cell Attractor Concept as a Tool to Advance Our Understanding of Cancer 129 6 Adaptation of Molecular Interaction Networks in Cancer Cells 141 7 The Role of Genomic Dark Matter in Cancer: Using AI to Shine a Light on It; Why Cancer Genes Are Not the Whole Story 163 III THE TIME DIMENSION OF CANCER 185 8 Darwinism, Not Mutationalism, for New Cancer Therapies 187 9 Cancer as a Reversion to an Ancestral Phenotype 205 10 Time and Timing in Oncology: What Therapy Scheduling Can Teach Us about Cancer Biology 227 IV THE MICRO-/ENVIRONMENT DIMENSION OF CANCER 245 11 Tissue Tension Modulates Metabolism and Chromatin Organization to Promote Malignancy 247 12 Cancer Metabolism and Therapeutic Perspectives: Exploiting Acidic, Nutritional, and Oxidative Stresses 271 13 Corrupted Vascular Tumor Niches Confer Aggressiveness and Chemoresistance to Neoplastic Cells 299 14 Metastasis as a Tug of War between Cell Autonomy and Microenvironmental Control: Readdressing Unresolved Questions in Cancer Metastasis 323 15 Niche Reconstruction to Revert or Transcend the Cancer State 353 V WHAT NEXT? 391 Contributors 397 Index 399
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