Cancer Immunotherapy (eBook, ePUB)

Immune Suppression and Tumor Growth
Redaktion: Prendergast, George C.; Jaffee, Elizabeth M.

• Format: ePub

Produktbeschreibung

There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer, and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumor immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers with an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease.

• Offers a synthesis of concepts that are useful to cancer immunologists and pharmacologists, who tend to work in disparate fields with little cross-communication
• Drs. Prendergast and Jaffee are internationally recognized leaders in cancer biology and immunology who have created a unique synthesis of fundamental and applied concepts in this important new area of cancer research
• Summarizes the latest insights into how immune escape defines an essential trait of cancer
• Includes numerous illustrations, including how molecular-targeted therapeutic drugs or traditional chemotherapy can be combined with immunotherapy to improve anti-tumor efficacy and how reversing immune suppression by the tumor can cause tumor regression

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 684
• Erscheinungstermin: 4. Juni 2013
• Englisch
• ISBN-13: 9780123946331
• Artikelnr.: 39131516

Inhaltsangabe

Part I: Principles of Cancer ImmunobiologyIntroductionCancer
Immunoediting: From Immune Surveillance to Immune EscapeImmunosurveillance:
Innate and Adaptive Anti-Tumor ImmunityCytokine Regulation of Immune
Tolerance to TumorsImmunological Sculpting: Natural Killer Cell Receptors
and LigandsImmune Escape: Immunosuppressive NetworksPart II: Cancer
TherapeuticsCytotoxic Chemotherapy in Clinical Treatment of CancerTargeted
Therapeutics in Cancer TreatmentConcepts in Pharmacology and
ToxicologyCancer Immunotherapy: Challenges and OpportunitiesCancer Vaccines
Part III: Targets and Tactics to Improve Cancer Immunotherapy By Defeating
Immune SuppressionImmunotherapy and Cancer Therapeutics: Why Partner?Immune
Stimulatory Features of Classical ChemotherapyDendritic Cells and
Co-Inhibitory MoleculesRegulatory T Cells in Tumor Immunity: Role of
Toll-like Receptors Tumor-associated Macrophages in Cancer Growth and
ProgressionTumor-associated Myeloid-derived Suppressor CellsProgrammed
Death Ligand-1 and Galectin-1: Pieces in the Puzzle of Tumor Immune
EscapeIDO in Immune Escape: Regulation and Therapeutic InhibitionArginase,
Nitric Oxide Synthase, and Novel Inhibitors of L-arginine Metabolism in
Immune ModulationSummary: Future Questions