Protein Misfolding Diseases (eBook, PDF)
Current and Emerging Principles and Therapies
Redaktion: Ramirez-Alvarado, Marina; Dobson, Christopher M.; Kelly, Jeffery W.
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Protein Misfolding Diseases (eBook, PDF)
Current and Emerging Principles and Therapies
Redaktion: Ramirez-Alvarado, Marina; Dobson, Christopher M.; Kelly, Jeffery W.
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An increasingly aging population will add to the number of individuals suffering from amyloid. Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific researchers, and doctors working with protein misfolding diseases bridge the gap between basic science and pharmaceutical applications to protein misfolding disease.
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- Produktdetails
- Verlag: John Wiley & Sons
- Seitenzahl: 1078
- Erscheinungstermin: 21. Juni 2010
- Englisch
- ISBN-13: 9780470572696
- Artikelnr.: 37297379
- Verlag: John Wiley & Sons
- Seitenzahl: 1078
- Erscheinungstermin: 21. Juni 2010
- Englisch
- ISBN-13: 9780470572696
- Artikelnr.: 37297379
INTRODUCTION TO THE WILEY SERIES ON PROTEIN AND PEPTIDE SCIENCE (Vladimir
N. Uversky). PART I PRINCIPLES OF PROTEIN MISFOLDING. 1 Why Proteins
Misfold (Silvia Campioni, Elodie Monsellier, and Fabrizio Chiti). 2
Endoplasmic Reticulum Stress and Oxidative Stress: Mechanisms and Link to
Disease (Jyoti D. Malhotra and Randal J. Kaufman). 3 Role of Molecular
Chaperones in Protein Folding (Kausik Chakraborty, Florian Georgescauld,
Manajit Hayer-Hartl, and F. Ulrich Hartl). 4 Kinetic Models for Protein
Misfolding and Association (Evan T. Powers and Frank A. Ferrone). 5
Toxicity in Amyloid Diseases (Massimo Stefani). 6 Autophagy: An Alternative
Degradation Mechanism for Misfolded Proteins (Maria Kon and Ana Maria
Cuervo). 7 Role of Posttranslational Modifications in Amyloid Formation
(Andisheh Abedini, Ruchi Gupta, Peter Marek, Fanling Meng, Daniel P.
Raleigh, Humeyra Taskent, and Sylvia Tracz). 8 Unraveling Molecular
Mechanisms and Structures of Self-Perpetuating Prions (Peter M. Tessier and
Susan Lindquist). 9 Caenorhabditis elegans as a Model System to Study the
Biology of Protein Aggregation and Toxicity (Elise A. Kikis, Anat Ben-Zvi,
and Richard I. Morimoto). 10 Using Drosophila to Reveal Insight Into
Protein Misfolding Diseases (Julide Bilen and Nancy M. Bonini). 11 Animal
Models to Study the Biology of Amyloid-ß Protein Misfolding in Alzheimer
Disease (Karen H. Ashe). PART II PROTEIN MISFOLDING DISEASE:
GAIN-OF-FUNCTION AND LOSS-OF-FUNCTION DISEASES. 12 Alzheimer Disease:
Protein Misfolding, Model Systems, and Experimental Therapeutics (Donald L.
Price, Alena V. Savonenko, Tong Li, Michael K. Lee, and Philip C. Wong). 13
Prion Disease Therapy: Trials and Tribulations (Valerie L. Sim and Byron
Caughey). 14 Misfolding and Aggregation in Huntington Disease and Other
Expanded Polyglutamine Repeat Diseases (Ronald Wetzel). 15 Systemic
Amyloidoses (Marina Ramirez-Alvarado and Joel N. Buxbaum). 16
Hemodialysis-Related Amyloidosis (David P. Smith, Alison E. Ashcroft, and
Sheena E. Radford). 17 Copper-Zinc Superoxide Dismutase, Its Copper
Chaperone, and Familial Amyotrophic Lateral Sclerosis (Duane D. Winkler,
Mercedes Prudencio, Celeste Karch, David R. Borchelt, and P. John Hart). 18
Alpha-1-Antitrypsin Deficiency (David A. Lomas and David H. Perlmutter). 19
Folding Biology of Cystic Fibrosis: A Consortium-Based Approach to Disease
(William E. Balch, Ineke Braakman, Jeff Brodsky, Raymond Frizzell, William
Guggino, Gergely L. Lukacs, Christopher Penland, Harvey Pollard, William
Skach, Eric Sorscher, and Philip Thomas). 20 Thiopurine S-Methyltransferase
Pharmacogenomics: Protein Misfolding, Aggregation, and Degradation (Fang Li
and Richard M. Weinshilboum). 21 Gaucher Disease (Tim Edmunds). 22 Cataract
as a Protein-Aggregation Disease (Yongting Wang and Jonathan A. King). 23
Islet Amyloid Polypeptide (Andisheh Abedini and Daniel P. Raleigh). PART
III ROLE OF ACCESSORY MOLECULES AND RISK FACTORS. 24 Role of Metals in
Alzheimer Disease (Blaine R. Roberts and Ashley I. Bush). 25 Why Study the
Role of Heparan Sulfate in In Vivo Amyloidogenesis? (Robert Kisilevsky and
John Ancsin). 26 Serum Amyloid P Component (Simon Kolstoe and Steve Wood).
27 Role of Oxidatively Stressed Lipids in Amyloid Formation and Toxicity
(Paul H. Axelsen and Hiroaki Komatsu). 28 Role of Oxidative Stress in
Protein Misfolding and/or Amyloid Formation (Johanna C. Scheinost, Daniel
P. Witter, Grant E. Boldt, and Paul Wentworth, Jr.). 29 Aging and
Aggregation-Mediated Proteotoxicity (Ehud Cohen and Andrew Dillin). PART IV
MEDICAL ASPECTS OF DISEASE: DIAGNOSIS AND CURRENT THERAPIES. 30 Imaging of
Misfolded Proteins (Harry LeVine, III). 31 Diagnosis of Systemic Amyloid
Diseases (Morie A. Gertz). 32 Identification of Biomarkers for Diagnosis of
Amyloid Diseases: Quantitative Free Light-Chain Assays (Jerry A. Katzmann).
33 Real-Time Observation of Amyloid-b Fibril Growth by Total Internal
Reflection Fluorescence Microscopy (Tadato Ban and Yuji Goto). 34 Current
and Future Therapies for Alzheimer Disease (Paramita Chakrabarty, Pritam
Das, and Todd E. Golde). 35 Current Therapies for Light-Chain Amyloidosis
(Angela Dispenzieri and Shaji Kumar). 36 Familial and Senile Amyloidosis
Caused by Transthyretin (Steven R. Zeldenrust and Merrill D. Benson). 37
Identifying Targets in a-Synuclein Metabolism to Treat Parkinson Disease
and Related Disorders (Julianna Tomlinson, Valerie Cullen, and Michael G.
Schlossmacher). 38 Emerging Molecular Targets in the Therapy of
Dialysis-Related Amyloidosis (Gennaro Esposito and Vittorio Bellotti). 39
Familial Amyloidosis Caused by Lysozyme (Mireille Dumoulin). 40 Therapeutic
Prospects for Polyglutamine Disease (Maria Pennuto and Kenneth H.
Fischbeck). PART V APPROACHES FOR NEW AND EMERGING THERAPIES. 41 Chemistry
and Biology of Amyloid Inhibition (Mark A. Findeis). 42 Immunotherapy in
Secondary and Light-Chain Amyloidosis (Jonathan Wall). 43 Anti-Misfolding
and Anti-Fibrillization Therapies for Protein Misfolding Disorders (Zane
Martin and Claudio Soto). 44 Therapies Aimed at Controlling Gene
Expression, Including Up-Regulating a Chaperone or Down-Regulating an
Amyloidogenic Protein (Gregor P. Lotz and Paul J. Muchowski). 45
Understanding and Ameliorating the TTR Amyloidoses (Steven M. Johnson, R.
Luke Wiseman, Natalia Reixach, Johan F. Paulsson, Sungwook Choi, Evan T.
Powers, Joel N. Buxbaum, and Jeffery W. Kelly). INDEX.
INTRODUCTION TO THE WILEY SERIES ON PROTEIN AND PEPTIDE SCIENCE (Vladimir
N. Uversky). PART I PRINCIPLES OF PROTEIN MISFOLDING. 1 Why Proteins
Misfold (Silvia Campioni, Elodie Monsellier, and Fabrizio Chiti). 2
Endoplasmic Reticulum Stress and Oxidative Stress: Mechanisms and Link to
Disease (Jyoti D. Malhotra and Randal J. Kaufman). 3 Role of Molecular
Chaperones in Protein Folding (Kausik Chakraborty, Florian Georgescauld,
Manajit Hayer-Hartl, and F. Ulrich Hartl). 4 Kinetic Models for Protein
Misfolding and Association (Evan T. Powers and Frank A. Ferrone). 5
Toxicity in Amyloid Diseases (Massimo Stefani). 6 Autophagy: An Alternative
Degradation Mechanism for Misfolded Proteins (Maria Kon and Ana Maria
Cuervo). 7 Role of Posttranslational Modifications in Amyloid Formation
(Andisheh Abedini, Ruchi Gupta, Peter Marek, Fanling Meng, Daniel P.
Raleigh, Humeyra Taskent, and Sylvia Tracz). 8 Unraveling Molecular
Mechanisms and Structures of Self-Perpetuating Prions (Peter M. Tessier and
Susan Lindquist). 9 Caenorhabditis elegans as a Model System to Study the
Biology of Protein Aggregation and Toxicity (Elise A. Kikis, Anat Ben-Zvi,
and Richard I. Morimoto). 10 Using Drosophila to Reveal Insight Into
Protein Misfolding Diseases (Julide Bilen and Nancy M. Bonini). 11 Animal
Models to Study the Biology of Amyloid-ß Protein Misfolding in Alzheimer
Disease (Karen H. Ashe). PART II PROTEIN MISFOLDING DISEASE:
GAIN-OF-FUNCTION AND LOSS-OF-FUNCTION DISEASES. 12 Alzheimer Disease:
Protein Misfolding, Model Systems, and Experimental Therapeutics (Donald L.
Price, Alena V. Savonenko, Tong Li, Michael K. Lee, and Philip C. Wong). 13
Prion Disease Therapy: Trials and Tribulations (Valerie L. Sim and Byron
Caughey). 14 Misfolding and Aggregation in Huntington Disease and Other
Expanded Polyglutamine Repeat Diseases (Ronald Wetzel). 15 Systemic
Amyloidoses (Marina Ramirez-Alvarado and Joel N. Buxbaum). 16
Hemodialysis-Related Amyloidosis (David P. Smith, Alison E. Ashcroft, and
Sheena E. Radford). 17 Copper-Zinc Superoxide Dismutase, Its Copper
Chaperone, and Familial Amyotrophic Lateral Sclerosis (Duane D. Winkler,
Mercedes Prudencio, Celeste Karch, David R. Borchelt, and P. John Hart). 18
Alpha-1-Antitrypsin Deficiency (David A. Lomas and David H. Perlmutter). 19
Folding Biology of Cystic Fibrosis: A Consortium-Based Approach to Disease
(William E. Balch, Ineke Braakman, Jeff Brodsky, Raymond Frizzell, William
Guggino, Gergely L. Lukacs, Christopher Penland, Harvey Pollard, William
Skach, Eric Sorscher, and Philip Thomas). 20 Thiopurine S-Methyltransferase
Pharmacogenomics: Protein Misfolding, Aggregation, and Degradation (Fang Li
and Richard M. Weinshilboum). 21 Gaucher Disease (Tim Edmunds). 22 Cataract
as a Protein-Aggregation Disease (Yongting Wang and Jonathan A. King). 23
Islet Amyloid Polypeptide (Andisheh Abedini and Daniel P. Raleigh). PART
III ROLE OF ACCESSORY MOLECULES AND RISK FACTORS. 24 Role of Metals in
Alzheimer Disease (Blaine R. Roberts and Ashley I. Bush). 25 Why Study the
Role of Heparan Sulfate in In Vivo Amyloidogenesis? (Robert Kisilevsky and
John Ancsin). 26 Serum Amyloid P Component (Simon Kolstoe and Steve Wood).
27 Role of Oxidatively Stressed Lipids in Amyloid Formation and Toxicity
(Paul H. Axelsen and Hiroaki Komatsu). 28 Role of Oxidative Stress in
Protein Misfolding and/or Amyloid Formation (Johanna C. Scheinost, Daniel
P. Witter, Grant E. Boldt, and Paul Wentworth, Jr.). 29 Aging and
Aggregation-Mediated Proteotoxicity (Ehud Cohen and Andrew Dillin). PART IV
MEDICAL ASPECTS OF DISEASE: DIAGNOSIS AND CURRENT THERAPIES. 30 Imaging of
Misfolded Proteins (Harry LeVine, III). 31 Diagnosis of Systemic Amyloid
Diseases (Morie A. Gertz). 32 Identification of Biomarkers for Diagnosis of
Amyloid Diseases: Quantitative Free Light-Chain Assays (Jerry A. Katzmann).
33 Real-Time Observation of Amyloid-b Fibril Growth by Total Internal
Reflection Fluorescence Microscopy (Tadato Ban and Yuji Goto). 34 Current
and Future Therapies for Alzheimer Disease (Paramita Chakrabarty, Pritam
Das, and Todd E. Golde). 35 Current Therapies for Light-Chain Amyloidosis
(Angela Dispenzieri and Shaji Kumar). 36 Familial and Senile Amyloidosis
Caused by Transthyretin (Steven R. Zeldenrust and Merrill D. Benson). 37
Identifying Targets in a-Synuclein Metabolism to Treat Parkinson Disease
and Related Disorders (Julianna Tomlinson, Valerie Cullen, and Michael G.
Schlossmacher). 38 Emerging Molecular Targets in the Therapy of
Dialysis-Related Amyloidosis (Gennaro Esposito and Vittorio Bellotti). 39
Familial Amyloidosis Caused by Lysozyme (Mireille Dumoulin). 40 Therapeutic
Prospects for Polyglutamine Disease (Maria Pennuto and Kenneth H.
Fischbeck). PART V APPROACHES FOR NEW AND EMERGING THERAPIES. 41 Chemistry
and Biology of Amyloid Inhibition (Mark A. Findeis). 42 Immunotherapy in
Secondary and Light-Chain Amyloidosis (Jonathan Wall). 43 Anti-Misfolding
and Anti-Fibrillization Therapies for Protein Misfolding Disorders (Zane
Martin and Claudio Soto). 44 Therapies Aimed at Controlling Gene
Expression, Including Up-Regulating a Chaperone or Down-Regulating an
Amyloidogenic Protein (Gregor P. Lotz and Paul J. Muchowski). 45
Understanding and Ameliorating the TTR Amyloidoses (Steven M. Johnson, R.
Luke Wiseman, Natalia Reixach, Johan F. Paulsson, Sungwook Choi, Evan T.
Powers, Joel N. Buxbaum, and Jeffery W. Kelly). INDEX.