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Over the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs. This new book (from the EIBC Book Series) covers recent advances made by top researchers in the field of metals in cells [the "metallome"] and include: regulated metal ion uptake and trafficking, sensing of metals within cells and across tissues, and identification of the vast cellular factors designed to orchestrate assembly of metal…mehr
Over the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs. This new book (from the EIBC Book Series) covers recent advances made by top researchers in the field of metals in cells [the "metallome"] and include: regulated metal ion uptake and trafficking, sensing of metals within cells and across tissues, and identification of the vast cellular factors designed to orchestrate assembly of metal cofactor sites while minimizing toxic side reactions of metals. In addition, it features aspects of metals in disease, including the role of metals in neuro-degeneration, liver disease, and inflammation, as a way to highlight the detrimental effects of mishandling of metal trafficking and response to "foreign" metals. With the breadth of our recently acquired understanding of metals in cells, a book that features key aspects of cellular handling of inorganic elements is both timely and important. At this point in our understanding, it is worthwhile to step back and take an expansive view of how far our understanding has come, while also highlighting how much we still do not know. The content from this book will publish online, as part of EIBC in December 2013, find out more about the Encyclopedia of Inorganic and Bioinorganic Chemistry, the essential online resource for researchers and students working in all areas of href="http://onlinelibrary.wiley.com/book/10.1002/9781119951438">inorganic and bioinorganic chemistry.
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Prof. Robert A. Scott (Editor-in-Chief Encyclopedia of Inorganic and Bioinorganic Chemistry) Distinguished Research Professor, University of Georgia, USA. Prof. Valeria Culotta, Biochemistry and Molecular Biology Department, Joint Departmental Affiliations Environmental Health Sciences Research in the Culotta lab focuses on the role of metal ions and oxygen radicals in biology and disease. Metal ions such as copper, iron and manganese are not only trace nutrients but can be quite toxic. One mechanism of toxicity is through generation of reactive oxygen species (ROS) that have been implicated in numerous human disorders from neurodegeneration to cancer to aging. Through molecular genetic approaches and high through-put genetic screens in yeast, we have identified a number genes and pathways that are involved in transition metal and reactive oxygen metabolism. Virtually all are well conserved throughout eukaryotes including humans. Our laboratory uses a combination of yeast, C. elegans and cell culture systems at the crossroads of bioinorganic chemistry, cell biology and molecular genetics.
Inhaltsangabe
Contributors xi Series Preface xix Volume Preface xxi PART 1: INTRODUCTION 1 Mechanisms Controlling the Cellular Metal Economy 3 Benjamin A. Gilston and Thomas V. O'Halloran PART 2: PROBING METALS AND CROSS TALK IN THE METALLOME 15 The Metallome 17 Vadim N. Gladyshev and Yan Zhang Cyanobacterial Models that Address Cross-Talk in Metal Homeostasis 39 Carl J. Patterson, Rafael Pernil, Andrew W. Foster and Nigel J. Robinson Sparing and Salvaging Metals in Chloroplasts 51 Crysten E. Blaby-Haas and Sabeeha S. Merchant Fluorescent Probes for Monovalent Copper 65 M. Thomas Morgan, Pritha Bagchi and Christoph J. Fahrni Fluorescent Zinc Sensors 85 Amy E. Palmer, Jose G. Miranda and Kyle P. Carter X-Ray Fluorescence Microscopy 99 James E. Penner-Hahn PART 3: MOVING METALS IN CELLS 111 Iron and Heme Transport and Trafficking 113 Yvette Y. Yien and Barry H. Paw Iron in Plants 131 Jessica B. Weng and Mary Lou Guerinot Transport of Nickel and Cobalt in Prokaryotes 145 Thomas Eitinger Transport Mechanism and Cellular Functions of Bacterial Cu(I)-ATPases 155 Jose M. Arguello, Teresita Padilla-Benavides and Jessica M. Collins Copper Transport in Fungi 163 Simon Labbe, Jude Beaudoin and Raphael Ioannoni Structural Biology of Copper Transport 175 Adrian G. Flores, Christopher R. Pope and Vinzenz M. Unger Zinc Transporters and Trafficking in Yeast 183 Yi-Hsuan Wu and David J. Eide Cadmium Transport in Eukaryotes 195 Nathan Smith, Wenzhong Wei and Jaekwon Lee PART 4: METALS IN REGULATION 207 Metal Specificity of Metallosensors 209 Khadine A. Higgins and David P. Giedroc Metal Homeostasis and Oxidative Stress in Bacillus subtilis 225 Zhen Ma and John D. Helmann Regulation of Manganese and Iron Homeostasis in the Rhizobia and Related alpha-Proteobacteria 237 Mark R. O'Brian The Iron Starvation Response in Saccharomyces cerevisiae 249 Caroline C. Philpott and Pamela M. Smith Hepcidin Regulation of Iron Homeostasis 265 Clara Camaschella and Laura Silvestri NikR: Mechanism and Function in Nickel Homeostasis 277 Michael D. Jones, Andrew M. Sydor and Deborah B. Zamble Regulation of Copper Homeostasis in Plants 289 Marinus Pilon and Wiebke Tapken Regulation of Zinc Transport 301 Taiho Kambe Selenoproteins--Regulation 311 Lucia A. Seale and Marla J. Berry PART 5: METALS IN CELLULAR DAMAGE AND DISEASE 321 Metals in Bacterial Pathogenicity and Immunity 323 Jennifer S. Cavet Manganese in Neurodegeneration 335 Daiana Silva Avila, Robson Luiz Puntel, Felix Antunes Soares, Joao Batista Teixeira da Rocha and Michael Aschner Iron Sequestration in Immunity 349 Colin Correnti and Roland K. Strong Molecular Basis of Hemochromatosis 361 Paul J. Schmidt Copper in Brain and Neurodegeneration 373 Jeffrey R. Liddell, Ashley I. Bush and Anthony R. White Copper Transporting ATPases in Mammalian Cells 395 Nan Yang and Svetlana Lutsenko Copper in Immune Cells 409 Karrera Y. Djoko, Maud E.S. Achard and Alastair G. McEwan Selenoenzymes and Selenium Trafficking: An Emerging Target for Therapeutics 421 William Self and Sarah Rosario Resistance Pathways for Metalloids and Toxic Metals 429 Zijuan Liu, Christopher Rensing and Barry P. Rosen PART 6: COFACTOR ASSEMBLY 443 Fe-S Cluster Biogenesis in Archaea and Bacteria 445 Harsimranjit K. Chahal, Jeff M. Boyd and F. Wayne Outten Mitochondrial Iron Metabolism and the Synthesis of Iron-Sulfur Clusters 473 Andrew Dancis and Paul A. Lindahl [FeFe]-Hydrogenase Cofactor Assembly 491 Eric M. Shepard, Amanda S. Byer, Eric S. Boyd, Kevin D. Swanson, John W. Peters and Joan B. Broderick [NiFe]-Hydrogenase Cofactor Assembly 507 Basem Soboh and R. Gary Sawers Copper in Mitochondria 517 Katherine E. Vest and Paul A. Cobine Mo Cofactor Biosynthesis and Crosstalk with FeS 529 Florian Bittner and Ralf R. Mendel Nitrogenase Cofactor Assembly 543 Jared A. Wiig, Chi Chung Lee, Markus W. Ribbe and Yilin Hu Index 555
Contributors xi Series Preface xix Volume Preface xxi PART 1: INTRODUCTION 1 Mechanisms Controlling the Cellular Metal Economy 3 Benjamin A. Gilston and Thomas V. O'Halloran PART 2: PROBING METALS AND CROSS TALK IN THE METALLOME 15 The Metallome 17 Vadim N. Gladyshev and Yan Zhang Cyanobacterial Models that Address Cross-Talk in Metal Homeostasis 39 Carl J. Patterson, Rafael Pernil, Andrew W. Foster and Nigel J. Robinson Sparing and Salvaging Metals in Chloroplasts 51 Crysten E. Blaby-Haas and Sabeeha S. Merchant Fluorescent Probes for Monovalent Copper 65 M. Thomas Morgan, Pritha Bagchi and Christoph J. Fahrni Fluorescent Zinc Sensors 85 Amy E. Palmer, Jose G. Miranda and Kyle P. Carter X-Ray Fluorescence Microscopy 99 James E. Penner-Hahn PART 3: MOVING METALS IN CELLS 111 Iron and Heme Transport and Trafficking 113 Yvette Y. Yien and Barry H. Paw Iron in Plants 131 Jessica B. Weng and Mary Lou Guerinot Transport of Nickel and Cobalt in Prokaryotes 145 Thomas Eitinger Transport Mechanism and Cellular Functions of Bacterial Cu(I)-ATPases 155 Jose M. Arguello, Teresita Padilla-Benavides and Jessica M. Collins Copper Transport in Fungi 163 Simon Labbe, Jude Beaudoin and Raphael Ioannoni Structural Biology of Copper Transport 175 Adrian G. Flores, Christopher R. Pope and Vinzenz M. Unger Zinc Transporters and Trafficking in Yeast 183 Yi-Hsuan Wu and David J. Eide Cadmium Transport in Eukaryotes 195 Nathan Smith, Wenzhong Wei and Jaekwon Lee PART 4: METALS IN REGULATION 207 Metal Specificity of Metallosensors 209 Khadine A. Higgins and David P. Giedroc Metal Homeostasis and Oxidative Stress in Bacillus subtilis 225 Zhen Ma and John D. Helmann Regulation of Manganese and Iron Homeostasis in the Rhizobia and Related alpha-Proteobacteria 237 Mark R. O'Brian The Iron Starvation Response in Saccharomyces cerevisiae 249 Caroline C. Philpott and Pamela M. Smith Hepcidin Regulation of Iron Homeostasis 265 Clara Camaschella and Laura Silvestri NikR: Mechanism and Function in Nickel Homeostasis 277 Michael D. Jones, Andrew M. Sydor and Deborah B. Zamble Regulation of Copper Homeostasis in Plants 289 Marinus Pilon and Wiebke Tapken Regulation of Zinc Transport 301 Taiho Kambe Selenoproteins--Regulation 311 Lucia A. Seale and Marla J. Berry PART 5: METALS IN CELLULAR DAMAGE AND DISEASE 321 Metals in Bacterial Pathogenicity and Immunity 323 Jennifer S. Cavet Manganese in Neurodegeneration 335 Daiana Silva Avila, Robson Luiz Puntel, Felix Antunes Soares, Joao Batista Teixeira da Rocha and Michael Aschner Iron Sequestration in Immunity 349 Colin Correnti and Roland K. Strong Molecular Basis of Hemochromatosis 361 Paul J. Schmidt Copper in Brain and Neurodegeneration 373 Jeffrey R. Liddell, Ashley I. Bush and Anthony R. White Copper Transporting ATPases in Mammalian Cells 395 Nan Yang and Svetlana Lutsenko Copper in Immune Cells 409 Karrera Y. Djoko, Maud E.S. Achard and Alastair G. McEwan Selenoenzymes and Selenium Trafficking: An Emerging Target for Therapeutics 421 William Self and Sarah Rosario Resistance Pathways for Metalloids and Toxic Metals 429 Zijuan Liu, Christopher Rensing and Barry P. Rosen PART 6: COFACTOR ASSEMBLY 443 Fe-S Cluster Biogenesis in Archaea and Bacteria 445 Harsimranjit K. Chahal, Jeff M. Boyd and F. Wayne Outten Mitochondrial Iron Metabolism and the Synthesis of Iron-Sulfur Clusters 473 Andrew Dancis and Paul A. Lindahl [FeFe]-Hydrogenase Cofactor Assembly 491 Eric M. Shepard, Amanda S. Byer, Eric S. Boyd, Kevin D. Swanson, John W. Peters and Joan B. Broderick [NiFe]-Hydrogenase Cofactor Assembly 507 Basem Soboh and R. Gary Sawers Copper in Mitochondria 517 Katherine E. Vest and Paul A. Cobine Mo Cofactor Biosynthesis and Crosstalk with FeS 529 Florian Bittner and Ralf R. Mendel Nitrogenase Cofactor Assembly 543 Jared A. Wiig, Chi Chung Lee, Markus W. Ribbe and Yilin Hu Index 555
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