Microarrays, widely recognized as the next revolution in molecular biology, enable scientists to analyze genes, proteins and other biological molecules on a genomic scale. This emerging technology, used in more than 10,000 laboratories already, is having an enormous impact in all areas of biomedicine and across the agricultural, biotechnology, and pharmaceutical industries. Mark Schenas Microarray Analysis is the first textbook in this revolutionary new field of study. This comprehensive and multidisciplinary text begins with an introduction to microarray analysis, and explores basic…mehr
Microarrays, widely recognized as the next revolution in molecular biology, enable scientists to analyze genes, proteins and other biological molecules on a genomic scale. This emerging technology, used in more than 10,000 laboratories already, is having an enormous impact in all areas of biomedicine and across the agricultural, biotechnology, and pharmaceutical industries. Mark Schenas Microarray Analysis is the first textbook in this revolutionary new field of study. This comprehensive and multidisciplinary text begins with an introduction to microarray analysis, and explores basic chemistry, biochemistry, and genomics. Separate chapters are devoted to surface chemistry, target and probe preparation, microarray manufacture and detection, and data analysis and modeling. Methodology, cleanroom technology, gene expression profiling, genetic screening and diagnostics, and novel technologies round out this classic textbook. Microarray Analysis provides any science student or professional all the tools required to understand this revolutionary technology.
Rapidly teaches students the fundamentals of microarrays
Describes protein microarrays and other rapidly advancing forefronts
Builds a conceptual foundation for the entire field
Presents commercial opportunities in microarray science
Emphasizes the exciting clinical applications of microarrays
MARK SCHENA, Ph.D., the "Father of Microarray Technology," trained with Dan Koshland at U.C. Berkeley, Keith Yamamoto at UCSF, and Ron Davis at Stanford University. He published the first paper on microarrays in Science in 1995, and has given more than 80 lectures in 15 countries since 1995. Dr. Schena was featured as one of the Stars of Genomics on the 2001 NOVA television documentary on the Human Genome Project, and is currently a visiting scholar at TeleChem/arrayit.com in Sunnyvale, California.
Inhaltsangabe
Preface. Introduction to Microarray Analysis. Introduction to Chemistry. Basics of Biochemistry. Genes and Genomes. Microarray Surfaces. Targets and Probes. Microarray Manufacturing. Microarray Detection. Microarray Informatics. Methodological Architecture. Cleanroom Technology. Gene Expression Profiling. Genetic Screening and Diagnostics. Novel Microarray Technologies. Commercial Opportunities A to Z. Future Trends: Chips in the Clinics. Appendix A: Prefixes. Appendix B: Unit Abbreviations. Appendix C: Technical Abbreviations. Appendix D: Conversions. Appendix E: Nucleic Acid Molecular Weight Calculations. Appendix F: Microarray Spot Area Calculations. Appendix G: Microarray Fluor Density Calculations. Appendix H: Microarray Target Density Calculations. Appendix I: Microarray Web Sites. References. Glossary. Answers. Index.
