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In 2003, the President's budget for bioterrorism defense totalled more than $5 billion. Today, the nation's top academic scientists are scrambling to begin work to understand Bacillus anthracis and develop new vaccines and drugs. However, just five years ago, only the US Department of Defense (DOD) seemed concerned about these "exotic" agents. In 1997, the DOD spent approximately $137 million on biodefense to protect the deployed force, while academe, industry, local governments, and most of our federal leadership was oblivious to, and in some cases doubtful of, the seriousness of the threat.…mehr

Produktbeschreibung
In 2003, the President's budget for bioterrorism defense totalled more than $5 billion. Today, the nation's top academic scientists are scrambling to begin work to understand Bacillus anthracis and develop new vaccines and drugs. However, just five years ago, only the US Department of Defense (DOD) seemed concerned about these "exotic" agents. In 1997, the DOD spent approximately $137 million on biodefense to protect the deployed force, while academe, industry, local governments, and most of our federal leadership was oblivious to, and in some cases doubtful of, the seriousness of the threat. The National Institutes of Health (NIH) received the largest budget increase in the organization's history. Fortunately, during this time of national urgency, a sound base exists on which to build our defenses against this new threat. A relatively small cadre of dedicated scientists within the US Army Medical Research and Materiel Command (USAMRMC) laid this foundation over the past 20 years.

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  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Erscheinungstermin: 27.10.2007
  • Englisch
  • ISBN-13: 9781592597642
  • Artikelnr.: 37348116
Inhaltsangabe
I. Preparation and Military Support for a Possible Bioterrorism Incident
Department of Defense Capabilities Supporting Bioterrorism Response
Anna Johnson-Winegar, Karl Semancik, Robert S. Borowski, Keith R. Vesely, Brenda Wyler, Matt Eussen, and John V. Wade
Modeling for Bioterrorism Incidents
Zygmunt F. Dembek
Biological Weapons Defense: Effect Levels
Ross D. LeClaire and M. Louise M. Pitt
II. Medical Countermeasures and Decontamination
Pathogenesis by Aerosol
M. Louise M. Pitt and Ross D. LeClaire
Bacillus anthracis and the Pathogenesis of Anthrax
Dominique M. Missiakas and Olaf Schneewind
Virologic and Pathogenic Aspects of the Variola Virus (Smallpox) as a Bioweapon
Robert G. Darling, Timothy H. Burgess, James V. Lawler, and Timothy P. Endy
Plague Vaccines: Retrospective Analysis and Future Developments
Jeffrey J. Adamovicz and Gerard P. Andrews
Medical Protection Against Brucellosis
David L. Hoover and Richard H. Borschel
Pathogenesis of and Immunity to Coxiella burnetii
David M. Waag and Herbert A. Thompson
Glanders: New Insights Into an Old Disease
David M. Waag and David DeShazer
Medical Countermeasures for Filoviruses and Other Viral Agents
Alan Schmaljohn and Michael Hevey Medical Defense Against Protein Toxin Weapons: Review and Perspective
Charles B. Millard
Antimicrobials for Biological Warfare Agents
Jon B. Woods
Nonspecific Immunomodulator Therapy: CpG
D. G. Cerys Rees, Arthur M. Krieg, and Richard W. Titball
Decontamination
Robert J. Hawley and Joseph P. Kozlovac
III. Emerging Threats and Future Preparation
Definition and Overview of Emerging Threats
Luther E. Lindler, Eileen Choffnes, and George W. Korch
Department of Defense Global Emerging Infections System Programs in Biodefense
Julie A. Pavlin and Patrick W. Kelley
Information Resources and Database Development for Defense Against Biological Weapons
Frank J. Lebeda, Murray Wolinsky, and Elliot J. Lefkowitz
Genomic Efforts With Biodefense Pathogens
Rekha Seshadri, Timothy D. Read, William C. Nierman, and Ian T. Paulsen
Genomics for Biodefense: Exploiting the Francisella tularensis Genome Sequence
Siv G. E. Andersson, Mats Forsman, Petra C. F. Oyston, and Richard W. Titball
Genetic Fingerprinting of Biodefense Pathogens for Epidemiology and Forensic Investigation
Luther E. Lindler, Xiao-Zhe Huang, May Chu, Ted L. Hadfield, and Michael Dobson
Yersinia pestis as an Emerged Pathogen: What Lessons Can Be Learned?
Luther E. Lindler
IV. Diagnostic Development for Biowarfare Agents
Requirements for Biological Threat Identification Systems
Erik A. Henchal and George V. Ludwig
DNA-Based Diagnostic Tests for Detection and Identification of Biological Weapons
Luther E. Lindler, David Norwood, Michael Dobson, and Ted L. Hadfield
Concepts for the Development of Immunodiagnostic Assays for Detection and Diagnosis of Biothreat Agents
George V. Ludwig, Cynthia A. Rossi, and Robert L. Bull
Index
Rezensionen
From the reviews:

"Acts of bioterrorism have not happened since the end of World War II except the distribution of anthrax spores in the US postal system in 2001 ... . This important book is dedicated and useful not only for governmental and public health workers but also for a broad group of readers up to practitioners who might come in contact with such events as the first ones." (Werner Köhler, International Journal of Medical Microbiology, Vol. 295, 2005)