Toxicogenomics-Based Cellular Models

Alternatives to Animal Testing for Safety Assessment
Herausgegeben:Kleinjans, Jos

• Gebundenes Buch

Produktbeschreibung

Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety. This resource offers cutting-edge information on the application of toxicogenomics to developing alternatives to current animal toxicity tests. By illustrating the development of toxicogenomics-based cellular models for critical endpoints of toxicity and providing real-world examples for validation and data analysis, this book provides an assessment of the current state of the field, as well as opportunities and challenges for the future. Written by renowned international toxicological experts, this book explores 'omics technology for developing new assays for toxicity testing and safety assessment and provides the reader with a focused examination of alternative means to animal testing.

Produktdetails

• Verlag: Academic Press
• Artikelnr. des Verlages: C2011-0-09673-4
• Seitenzahl: 362
• Erscheinungstermin: 29. Januar 2014
• Englisch
• Abmessung: 244mm x 194mm x 25mm
• Gewicht: 907g
• ISBN-13: 9780123978622
• ISBN-10: 0123978629
• Artikelnr.: 40029374

Inhaltsangabe

Chapter 1. Introduction and Scoping Chapter 2. Genotoxicity and Carcinogenesis Chapter 3. Immunotoxicity Chapter 4. Reproduction Toxicity Chapter 5. Organ Toxicity Chapter 6. Toxicoinformatics Chapter 7. Validating Toxicogenomics Assays Chapter 8. Implementation Outlook

Rezensionen

"Researchers in genetics, toxicology, and other medical and public health specialties describe the current progress in developing toxicogenomics-based cellular models for chemical-induced carcinogenicity, immunotoxicity, and reproductive toxicity, all important endpoint of toxicity, the evaluation of which now costs large numbers of animal lives." --ProtoView.com, April 2014