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Today, diabetes as a disease is endemic to all people in the world. Diabetes is a deadly disease that affects all the vital organs of the human body. Diabetes usually genetically inherited talent is recessive in cells to induce diabetes. However, indiscriminate use of sugars and carbohydrates also increase the susceptibility of cells to induce diabetes. The book of genetic mutations induced diabetes analyzed and the analysis we have put ICT. In this research in a variety of polymorphisms in genetic susceptibility to type 2 diabetes have studied.Changes in gene activity and content PGC-1a, probably due to its polymorphisms far-reaching effects on metabolic processes in patients with type 2 diabetes. This study aimed to determine the PGC-1a gene polymorphisms and T2D Thr394Thr meta-analysis was performed.