Andere Kunden interessierten sich auch für
![Advances in Genetics]( "Advances in Genetics")
Advances in Genetics139,99 €![DNA Repair and Human Disease]( "DNA Repair and Human Disease")
DNA Repair and Human Disease116,99 €![Genetics of Stem Cells]( "Genetics of Stem Cells")
Genetics of Stem Cells139,99 €![Rett Syndrome mutations: molecular alterations at neuronal synapses]( "Rett Syndrome mutations: molecular alterations at neuronal synapses")
Rett Syndrome mutations: molecular alterations at neuronal synapses32,99 €![The Battle Genes for Survival]( "The Battle Genes for Survival")
The Battle Genes for Survival51,99 €![Myristica Swamps: An Unique and Threatened Ecosystem of Western Ghats]( "Myristica Swamps: An Unique and Threatened Ecosystem of Western Ghats")
Myristica Swamps: An Unique and Threatened Ecosystem of Western Ghats48,99 €![Analysis of growth, reproductive and survival traits in Tswana cattle]( "Analysis of growth, reproductive and survival traits in Tswana cattle")
Analysis of growth, reproductive and survival traits in Tswana cattle36,99 €
Brains from patients with AD reveal a markedly down regulaton of IGF-1R expression and these changes progress with severity of neurodegeneration. To investigate the role of neuronal IGF-1R signaling in AD a neuron-specific IGF-1R deficient mice were generated and were crossed with mice expressing mutated human APP which was found in a Swedish family with early-onset AD. The offsprings of these mice were analysed. Kaplan-Meier-analysis after 60 weeks of observation revealed that nIGF-1R knockout mice were protected against premature mortality of AD mice and showed reduced Abeta accumulation. In addition Abeta plaque burden in animals with neuronal IGF-1R deletion was also reduced compared to AD animals. Taken together IGF-1R mediated signals influence APP processing leading to reduced Abeta accumulation and amyloid plaque burden. Thus, downregulation of IGF-1R observed in brain of patients suffering from Alzheimer's disease is most likely a compensatory phenomenon.