Pulmonary Arterial Hypertension

Diagnosis and Evidence-Based Treatment
Herausgegeben:Barst, Robyn

• Gebundenes Buch

Produktbeschreibung

- First book dedicated to this disease, previously thought to be incurable, but with the advent of new drugs, now amenable to management and a much improved prognosis for patients

- From the PAH Association, the leading experts in field

- Incorporates the latest AACP management guidelines

- Includes evidence-based treatment algorithms based on the recently updated ACCP Guidelines for Medical Treatment

- Aimed at specialists in pulmonology and cardiovascular disease, this volume provides the clinician with the most up to date information on the effective management of PAH

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Pulmonary hypertension is frequently misdiagnosed and has often progressed to a late stage by the time it is accurately diagnosed. It has therefore long been considered untreatable and incurable with an overall very poor survival rate. However, new treatments are now available which have significantly improved prognosis. Recent data demonstrate survival is continuing to improve, with patients living for fifteen to twenty years or longer after diagnosis with an overall good quality of life.

In this work, each chapter will discuss therapeutic options with reference to the pre clinical studies which provided the rationale for their clinical development. The book will also include evidence-based treatment algorithms based on the 2007 update of the ACCP Guidelines for Medical Treatment of Pulmonary Hypertension.

Aimed at specialists in pulmonary and cardiovascular disease, this volume provides the clinician with the most up to date information on the effective management of pulmonary hypertension.

Produktdetails

• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 270
• Erscheinungstermin: 1. Juli 2008
• Englisch
• Abmessung: 249mm x 173mm x 22mm
• Gewicht: 680g
• ISBN-13: 9780470059722
• ISBN-10: 0470059729
• Artikelnr.: 23383636

Autorenporträt

Robyn J. Barst, MD, Professor of Pediatrics (in Medicine); Director, Pulmonary Hypertension Center, Columbia University Medical Center, New York, NY, USA Dr Barst is chair of the 'Scientific Leadership Council' of the Pulmonary Hypertension Association, a group of more than twenty internationally recognized leaders in the field of PAH. The mission of the SLC is 'to provide medical and scientific leadership for the Association by proactively facilitating the development of new knowledge about pulmonary hypertension, actively disseminating knowledge about pulmonary hypertension to medical and public audiences, and advocating and raising awareness about pulmonary hypertension. The editor and contributors are all members of the SLC, and include many well-known names including Lewis Rubin, George Simmoneau, Nazarino Galie, and David Badesch. This text is intended to be the 'official' work on the subject. Further evidence of the standing of the contributors is the medical centers involved in the SLC, which include the Mayo Clinic, Columbia Presbyterian Medical Center, University of California San Diego, UCLA, Duke, Rush Presbyterian, University of Colorado, University of Utah, Vanderbilt, the University of Alabama at Birmingham, and the University of Pennsylvania. The SLC also has international members from Italy, Ireland, Germany, and Canada. Dr Barst is? on the Editorial Board of Circulation, the official Journal of the American Heart Association, and for Chest, the official journal for the American Thoracic Society. Member of European Society of Cardiology Task Force for Primary Pulmonary Hypertension, Board Member of the International Society for Heart and Lung Transplantation.

Inhaltsangabe

Preface Contributors. 1 Introduction (Robyn J. Barst). 2 Diagnosis and
assessment of pulmonary arterial hypertension (Michael D. McGoon, Adam
Torbicki and Ronald J. Oudiz). 2.1 Hemodynamics of pulmonary hypertension.
2.2 Venice classification. 2.3 Overview of the diagnostic process
(algorithm). 2.4 Screening (identifying a pre-existing risk). 2.5 Detection
(discovering pulmonary hypertension). 2.6 Definition (diagnosing the
clinical context). 2.7 Prediction (estimating prognosis). 2.8 Principles of
follow-up (evaluating and responding to outcome). 2.9 Specific tests in the
evaluation of pulmonary hypertension. 3 Conventional therapy in pulmonary
arterial hypertension (Richard N. Channick). 3.1 Calcium channel
antagonists. 3.2 Diuretics. 3.3 Warfarin. 3.4 Supplemental oxygen. 3.5
Inotropic therapy. 3.6 General measures. 3.7 Conclusions. 4 Prostanoid
treatment for pulmonary arterial hypertension (Olivier Sitbon and Gérald
Simonneau). 4.1 Epoprostenol. 4.2 Treprostinil. 4.3 Iloprost. 4.4
Beraprost. 4.5 Treatment selection. 4.6 Conclusions. 5 Endothelin receptor
antagonists in pulmonary arterial hypertension (David B. Badesch and Marc
Humbert). 5.1 Bosentan. 5.2 Sitaxsentan. 5.3 Ambrisentan. 5.4 Safety and
tolerability with endothelin receptor antagonists. 5.5 Conclusions. 6
Phosphodiesterase-5 inhibitors in pulmonary arterial hypertension (Hossein
A. Ghofrani, Werner Seeger and Friedrich Grimminger). 6.1 The origins of
phosphodiesterase-5 inhibitor development. 6.2 Pulmonary hypertension as a
new indication for phosphodiesterase-5 inhibitor treatment. 6.3 Role of
phosphodiesterase-5 in the pulmonary vasculature. 6.4 Clinical experience
with sildenafil for the treatment of chronic pulmonary hypertension. 6.5
Pivotal trial and approval of sildenafil for the treatment of pulmonary
arterial hypertension (SUPER-1 study). 6.6 Other phosphodiesterase-5
inhibitors. 6.7 Combination therapy. 6.8 Potential new indications for
phosphodiesterase-5 inhibitors outside pulmonary arterial hypertension. 6.9
Conclusions. 7 Combination therapy for pulmonary arterial hypertension
(Anne Keogh and Marius Hoeper). 7.1 Background. 7.2 Combination therapy to
date. 7.3 Conclusions. 8 Interventional and surgical modalities of
treatment for pulmonary arterial hypertension (Julio Sandoval and Ramona
Doyle). 8.1 Introduction. 8.2 Atrial septostomy. 8.3 Pulmonary
endarterectomy in chronic thromboembolic pulmonary hypertension. 8.4 Lung
transplantation for pulmonary hypertension. 8.5 Conclusions. 9 End points
and clinical trial design in pulmonary arterial hypertension: Clinical and
regulatory perspectives (Andrew J. Peacock). 9.1 Introduction. 9.2 Trial
design. 9.3 End points in trials of therapy for pulmonary arterial
hypertension. 9.4 Conclusions. 10 Comparative analysis of clinical trials
and evidence-based treatment algorithm for pulmonary arterial hypertension
(Nazzareno Galiè, Alessandra Manes, Naushad Hirani and Robert Naeije). 10.1
Introduction. 10.2 Randomized controlled studies. 10.3 Long-term
continuation studies. 10.4 Combination studies. 10.5 Evidence-based
treatment algorithm. 10.6 Conclusions. 11 Diagnosis and assessment of
non-pulmonary arterial hypertension masquerading as idiopathic pulmonary
arterial hypertension: Diastolic heart failure - evaluation and
interactions (Mardi Gomberg-Maitland and Stuart Rich). 11.1 Definition of
heart failure. 11.2 Epidemiology. 11.3 Physiology. 11.4 Evaluation of
diastolic heart failure: Invasive and noninvasive techniques. 11.5
Diagnosis and treatment of diastolic dysfunction. 11.6 Pulmonary
hypertension and diastolic dysfunction. 11.7 Conclusions. 12 Treatment of
pulmonary arterial hypertension: A look to the future (Lewis J. Rubin).
12.1 Therapy of pulmonary arterial hypertension. 12.2 Measuring outcomes
and monitoring the course of therapy. 12.3 Conclusions. Index.