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The present book is an overview of original research on Ketamine and Propofol in pediatric dental sedation. Ketamine has been widely used as a sedative agent for dental procedures outside the operating room in various doses and combinations. Propofol has been used primarily as a deep sedative or total intra-venous anesthesia (TIVA) both inside and outside operating room. The present book is an attempt to review the original research on Ketamine and Propofol to aid in making evidence based decisions.