This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject. * Presents a clinically oriented guide to the diseases caused by neurodegeneration * Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually * Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson's Disease, Alzheimer's Disease, Amyotrophic Lateral…mehr
This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject. * Presents a clinically oriented guide to the diseases caused by neurodegeneration * Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually * Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson's Disease, Alzheimer's Disease, Amyotrophic Lateral Sclerosis/Motor Neuron Disease, and Multiple Sclerosis as well as less common diseases * Edited by globally leading authorities on the subject, and written by expert contributing authors
About the Editors Professor Anthony Schapira is Professor of Neurological Science and Head of the Department of Clinical Neuroscience at the UCL Institute of Neurology, London, UK and Chairman of Clinical Neurosciences Specialties. Zbigniew Wszolek, MD, is Professor of Neurology in the Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA. Ted M.Dawson, MD, PhD, is Leonard and Madlyn Abramson Professor of Neurodegenerative Diseases and Scientific Director in the Institute for Cell Engineering, Johns Hopkins University, Baltimore, Maryland, USA. Professor Nicholas Wood is Research Director of the UCL Institute of Genetics and Galton Professor of Genetics at UCL National Hospital for Neurology and Neurosurgery, Institute of Neurology, London, UK.
Inhaltsangabe
List of Contributors vi Preface ix Dedication x 1 Pathology of Brain Aging 1 Janna H. Neltner and Peter T. Nelson 2 Protein Aggregation and Neurodegeneration: Tauopathies and Synucleinopathies 12 Michel Goedert 3 Prion Degeneration 25 James A. Mastrianni 4 Excitotoxicity 37 Mark P. Mattson 5 Etiology and Pathogenesis of Parkinson Disease 46 Ruth-Mary deSouza and Anthony H.V. Schapira 6 Parkinson Disease: Treatment Options - Surgical Therapy 53 Travis S. Tierney and Andres M. Lozano 7 Multiple System Atrophy: Clinical Genetics and Neuropathology 58 Lucia V. Schottlaender Anna Sailer Zeshan Ahmed Dennis W. Dickson Henry Houlden and Owen A. Ross 8 Progressive Supranuclear Palsy 72 Huw R. Morris 9 Dementia with Lewy Bodies 83 Rodolfo Savica and David S. Knopman 10 Corticobasal Degeneration 93 Keith A. Josephs Jr. 11 Alzheimer's Disease 102 Qurat ul Ain Khan and Neill R. Graff-Radford 12 Frontotemporal Dementia 115 Christian W. Wider Barbara Jasinska-Myga Takuya Konno and Zbigniew K. Wszolek 13 Prion Diseases and Other Rapidly Progressive Dementias 126 Eric Eggenberger and Daniel L. Murman 14 Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis 137 Kevin B. Boylan Mark A. Ross and Eric J. Sorenson 15 Hereditary Spastic Paraplegia 161 Pawel P. Liberski and Craig Blackstone 16 Spinal Muscular Atrophy 179 Joseph R. Wooley Melissa E. Crowder Noah J. Pyles and Charlotte J. Sumner 17 Spinal and Bulbar Muscular Atrophy (Kennedy Disease) 202 Erich Peter Bosch 18 Optic Neuropathies 211 Desmond Kidd 19 Peripheral Nerve Neuropathies Including Charcot-Marie-Tooth Disease 218 Amelie Pandraud and Henry Houlden 20 Axonal Loss and Neurodegeneration in Multiple Sclerosis 238 Ranjan Dutta Jacqueline Chen Nobuhiko Ohno Daniel Ontaneda and Bruce D. Trapp 21 Huntington's Disease and Other Choreas 248 Salman Haider Edward Wild and Sarah J. Tabrizi 22 Spinocerebellar Ataxias 284 H. Brent Clark and Harry T. Orr 23 Ataxia Telangiectasia 296 Malcolm Taylor 24 Niemann-Pick Disease 303 Marc C. Patterson 25 X-linked Adrenoleukodystrophy 309 Deborah L. Renaud 26 Neurodegeneration with Brain Iron Accumulation Wilson Disease and Manganism 317 Alisdair McNeill Index 327
List of Contributors vi Preface ix Dedication x 1 Pathology of Brain Aging 1 Janna H. Neltner and Peter T. Nelson 2 Protein Aggregation and Neurodegeneration: Tauopathies and Synucleinopathies 12 Michel Goedert 3 Prion Degeneration 25 James A. Mastrianni 4 Excitotoxicity 37 Mark P. Mattson 5 Etiology and Pathogenesis of Parkinson Disease 46 Ruth-Mary deSouza and Anthony H.V. Schapira 6 Parkinson Disease: Treatment Options - Surgical Therapy 53 Travis S. Tierney and Andres M. Lozano 7 Multiple System Atrophy: Clinical Genetics and Neuropathology 58 Lucia V. Schottlaender Anna Sailer Zeshan Ahmed Dennis W. Dickson Henry Houlden and Owen A. Ross 8 Progressive Supranuclear Palsy 72 Huw R. Morris 9 Dementia with Lewy Bodies 83 Rodolfo Savica and David S. Knopman 10 Corticobasal Degeneration 93 Keith A. Josephs Jr. 11 Alzheimer's Disease 102 Qurat ul Ain Khan and Neill R. Graff-Radford 12 Frontotemporal Dementia 115 Christian W. Wider Barbara Jasinska-Myga Takuya Konno and Zbigniew K. Wszolek 13 Prion Diseases and Other Rapidly Progressive Dementias 126 Eric Eggenberger and Daniel L. Murman 14 Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis 137 Kevin B. Boylan Mark A. Ross and Eric J. Sorenson 15 Hereditary Spastic Paraplegia 161 Pawel P. Liberski and Craig Blackstone 16 Spinal Muscular Atrophy 179 Joseph R. Wooley Melissa E. Crowder Noah J. Pyles and Charlotte J. Sumner 17 Spinal and Bulbar Muscular Atrophy (Kennedy Disease) 202 Erich Peter Bosch 18 Optic Neuropathies 211 Desmond Kidd 19 Peripheral Nerve Neuropathies Including Charcot-Marie-Tooth Disease 218 Amelie Pandraud and Henry Houlden 20 Axonal Loss and Neurodegeneration in Multiple Sclerosis 238 Ranjan Dutta Jacqueline Chen Nobuhiko Ohno Daniel Ontaneda and Bruce D. Trapp 21 Huntington's Disease and Other Choreas 248 Salman Haider Edward Wild and Sarah J. Tabrizi 22 Spinocerebellar Ataxias 284 H. Brent Clark and Harry T. Orr 23 Ataxia Telangiectasia 296 Malcolm Taylor 24 Niemann-Pick Disease 303 Marc C. Patterson 25 X-linked Adrenoleukodystrophy 309 Deborah L. Renaud 26 Neurodegeneration with Brain Iron Accumulation Wilson Disease and Manganism 317 Alisdair McNeill Index 327
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