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Machine learning is a sub part of Artificial intelligence (AI). With the ongoing advancements in science and technology, machines are being made efficient to perform the tasks of human brains. Deep learning, data mining, IoT, all of these have collectively been used to make machines lively and intelligent workers. In this project Human disease prediction application of ML has been designed. If used in the medical field, it could save lots of time in diagnosis of any disease and at the same time improve accuracy with just a click. Its Graphics User Interface has been designed on Tinkter Tool kit using Python programming language. It consists of personal details of patient symptoms of patient and based on those symptoms the diagnosed disease. Further, this book is also targeted at research, development and design engineers.