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Bisoprolol fumarate (BF) is a synthetic _1- cardio selective adrenoreceptorblocking agent. BF can only used in treatment of cardiovascular disease such as (Hypertension and Myocardial Infarction). This is experimental study to bone showed the local effect of beta -1 selective blocker Bisoprolol fumarate gel 1% (BFG1%) on bone healing . The aims of this study were to demonstrate the physicochemical properties of BFG1% as well as identify the effect of this preparation on bone healing in rabbits through measuring certain biochemical parameters histological in addition to histomorphometric examination of the induced defect on rabbit's femur.