Topical and Transdermal Drug Delivery

Principles and Practice
Herausgegeben von Benson, Heather A. E.; Watkinson, Adam C.

• Gebundenes Buch

Produktbeschreibung

Practical drug development approaches presented by leading experts

Designed to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field and then demonstrates how these principles are put into practice in the design and development of new drug products. Drawing together and reviewing the latest research findings, the book focuses on practical, tested, and proven approaches that are backed by industry case studies and the authors' firsthand experience. Moreover, the book emphasizes the mechanistic information that is essential for successful drug product development.

Topical and Transdermal Drug Delivery: Principles and Practice is divided into two parts:
Part One, Current Science, Skin Permeation, and Enhancement Approaches, offers readers a fundamental understanding of the underlying science in the field. It describes the principles and techniques needed to successfully perform experimental approaches, covering such issues as skin permeation, enhancement, and assessment.
Part Two, Topical and Transdermal Product Development, guides readers through the complete product development process from concept to approval, offering practical tips and cautions from experts in the field. This part also discusses regulations that are specific to the development of dermal drug products. The final chapter explores current and future trends, forecasting new development techniques and therapeutics.

Throughout the book, the authors clearly set forth the basic science and experimental procedures, making it possible for researchers to design their own experimental approaches and accurately interpret their results.

With contributions from experienced drug researchers, this text is highly recommended for all researchers involved in topical and transdermal product development who need to know both the state of the science and the standards of practice.

Produktdetails

• Verlag: Wiley & Sons
• Artikelnr. des Verlages: 14545029000
• 1. Auflage
• Seitenzahl: 464
• Erscheinungstermin: 13. Dezember 2011
• Englisch
• Abmessung: 240mm x 161mm x 29mm
• Gewicht: 771g
• ISBN-13: 9780470450291
• ISBN-10: 0470450290
• Artikelnr.: 33684688

Autorenporträt

Paul Benson has been providing financial planning advice for more than 20 years, initially as an employee of one of Australia's major banks, and since 2005 as the principal of his own firm Guidance Financial Services. Paul's passion for financial independence comes from working with clients over so many years: seeing the different journeys of people's lives, what brings them happiness, and what causes stress and worry. Paul launched his Financial Autonomy podcast in 2017. Initially it was produced entirely as a family affair - Paul recorded the audio, his son created the theme music and did the editing, and his wife provided the outro. Today Financial Autonomy is one of the most popular personal finance podcasts in Australia. Paul holds a Bachelor of Business in Economics and Finance, and is a Certified Financial Planner. When not thinking about finances, Paul enjoys family time with his wife and two teenage sons. He loves playing board games - Settlers of Catan being a particular favourite - running, orienteering, and getting down to Williamstown beach during the warmer months for an ocean swim. Financial Autonomy is his first book.

Inhaltsangabe

Preface ix About the Editors xi Contributors xiii Part One Current Science,
Skin Permeation, and Enhancement Approaches 1. Skin Structure, Function,
and Permeation 3 Heather A.E. Benson 2. Passive Skin Permeation Enhancement
23 Majella E. Lane, Paulo Santos, Adam C. Watkinson, and Jonathan Hadgraft
3. Electrical and Physical Methods of Skin Penetration Enhancement 43
Jeffrey E. Grice, Tarl W. Prow, Mark A.F. Kendall, and Michael S. Roberts
4. Clinical Applications of Transdermal Iontophoresis 67 Dhaval R. Kalaria,
Sachin Dubey, and Yogeshvar N. Kalia 5. In Vitro Skin Permeation
Methodology 85 Barrie Finnin, Kenneth A. Walters, and Thomas J. Franz 6.
Skin Permeation Assessment: Tape Stripping 109 Sandra Wiedersberg and Sara
Nicoli 7. Skin Permeation Assessment: Microdialysis 131 Rikke Holmgaard,
Jesper B. Nielsen, and Eva Benfeldt 8. Skin Permeation: Spectroscopic
Methods 155 Jonathan Hadgraft and Majella E. Lane 9. Skin Permeation
Assessment in Man: In Vitro-In Vivo Correlation 167 Paul A. Lehman, Sam G.
Raney, and Thomas J. Franz 10. Risk Assessment 183 Jon R. Heylings Part Two
Topical and Transdermal Product Development 11. An Overview of Product
Development from Concept to Approval 203 Adam C. Watkinson 12. Regulatory
Aspects of Drug Development for Dermal Products 217 William K. Sietsema 13.
Toxicological and Pre-clinical Considerations for Novel Excipients and New
Chemical Entities 233 Andrew Makin and Jens Thing Mortensen 14. Topical
Product Formulation Development 255 Marc B. Brown, Robert Turner, and Sian
T. Lim 15. Transdermal Product Formulation Development 287 Kenneth J.
Miller 16. Sensitivity and Irritation Testing 309 Belum Viswanath Reddy,
Geetanjali Sethi, and Howard I. Maibach 17. New Product Development for
Transdermal Drug Delivery: Understanding the Market Opportunity 345 Hugh
Alsop 18. Transdermal and Topical Drug Delivery Today 357 Adam C. Watkinson
19. Current and Future Trends: Skin Diseases and Treatment 367 Simon G.
Danby, Gordon W. Duff, and Michael J. Cork Index 409