Hydrogen Peroxide and Cell Signaling, Part C (eBook, ePUB)

• Format: ePub

Produktbeschreibung

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the third of three volumes on hydrogen peroxide and cell signaling, and includes chapters on such topics as the biological chemistry of hydrogen peroxide, reactive oxygen species in the activation of MAP kinases, and investigating the role of reactive oxygen species in regulating autophagy.

• Continues the legacy of this premier serial with quality chapters authored by leaders in the field
• Covers hydrogen peroxide and cell signaling
• Contains chapters on such topics as the biological chemistry of hydrogen peroxide, reactive oxygen species in the activation of MAP kinases, and investigating the role of reactive oxygen species in regulating autophagy

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 384
• Erscheinungstermin: 11. Juli 2013
• Englisch
• ISBN-13: 9780124055407
• Artikelnr.: 43851291

Autorenporträt

ENRIQUE CADENAS, MD, PhD, received his PhD in biochemistry from the University of Buenos Aires, School of Medicine. He is professor of pharmacology and pharmaceutical sciences at the University of Southern California School of Pharmacy and of biochemistry and molecular biology at the University of Southern California Keck School of Medicine, and doctor honoris causa (medicine) at the University of Linköping, Sweden. Cadenas was president of the Society for Free Radical Research International (SFRRI) and is fellow of the Society for Free Radical Biology & Medicine. He served the scientific community by participating on NIH study sections (2002-2006; chair 2006-2008). His research interests include energy and redox metabolism in brain aging and the coordinated inflammatory-metabolic responses in brain and neurodegenerative diseases.

Inhaltsangabe

1. 1. The Biological Chemistry of Hydrogen Peroxide
      
   2. Reactive Oxygen Species in the Activation of MAP Kinases
      
   3. Hydrogen Peroxide Signaling Mediator in the Activation of p38 MAPK in Vascular Endothelial Cells
      
   4. In vivo Imaging of Nitric Oxide and Hydrogen Peroxide in Cardiac Myocytes
      
   5. Methods for Studying Oxidative Regulation of Protein Kinase C
      
   6. P66Shc, Mitochondria and the Generation of Reactive Oxygen Species
      
   7. Detecting Disulfide Bound Complexes and the Oxidative Regulation of Cyclic Nucleotide Dependent Protein Kinases by H₂O₂
      
   8. Redox Regulation of Protein Tyrosine Phosphatases: Methods for Kinetic Analysis of Covalent Enzyme Inactivation
      
   9. Activation of Nrf2 by H₂O₂: De novo Synthesis versus Nuclear Translocation
      
   10. H₂O₂ in the Induction of NF-k B-Dependent Selective Gene Expression
       
   11. Detection of H2O2-Mediated Phosphorylation of Kinase-Inactive PDGFRa
       
   12. Genetic Modifier Screens to Identify Components of a Redox-Regulated Cell Adhesion and Migration Pathway
       
   13. Investigating the Role of Reactive Oxygen Species in Regulating Autophagy
       
   14. H2O2: A Chemoattractant?
       
   15. Measuring Mitochondrial Uncoupling Protein-2 Level and Activity in Insulinoma Cells
       
   16. Effects of H2O2 on Insulin Signaling and the Glucose Transport System in Mammalian Skeletal Muscle
       
   17. Monitoring of Hydrogen Peroxide and Other Reactive Oxygen and Nitrogen Species Generated by Skeletal Muscle