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Research in nano and cell mechanics has received much attention from the scientific community as a result of society needs and government initiatives to accelerate developments in materials, manufacturing, electronics, medicine and healthcare, energy, and the environment. Engineers and scientists are currently engaging in increasingly complex scientific problems that require interdisciplinary approaches. In this regard, studies in this field draw from fundamentals in atomistic scale phenomena, biology, statistical and continuum mechanics, and multiscale modeling and experimentation. As a…mehr
Research in nano and cell mechanics has received much attention from the scientific community as a result of society needs and government initiatives to accelerate developments in materials, manufacturing, electronics, medicine and healthcare, energy, and the environment. Engineers and scientists are currently engaging in increasingly complex scientific problems that require interdisciplinary approaches. In this regard, studies in this field draw from fundamentals in atomistic scale phenomena, biology, statistical and continuum mechanics, and multiscale modeling and experimentation. As a result, contributions in these areas are spread over a large number of specialized journals, which prompted the Editors to assemble this book. Nano and Cell Mechanics: Fundamentals and Frontiers brings together many of the new developments in the field for the first time, and covers fundamentals and frontiers in mechanics to accelerate developments in nano- and bio-technologies. Key features: * Provides an overview of recent advances in nano and cell mechanics. * Covers experimental, analytical, and computational tools used to investigate biological and nanoscale phenomena. * Covers fundamentals and frontiers in mechanics to accelerate developments in nano- and bio-technologies. * Presents multiscale-multiphysics modeling and experimentation techniques. * Examines applications in materials, manufacturing, electronics, medicine and healthcare. Nano and Cell Mechanics: Fundamentals and Frontiers is written by internationally recognized experts in theoretical and applied mechanics, applied physics, chemistry, and biology. It is an invaluable reference for graduate students of nano- and bio-technologies, researchers in academia and industry who are working in nano and cell mechanics, and practitioners who are interested in learning about the latest analysis tools. The book can also serve as a text for graduate courses in theoretical and applied mechanics, mechanical engineering, materials science, and applied physics.
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Horacio D. Espinosa, Northwestern University, USA Horacio D. Espinosa is the James and Nancy Farley Professor of Mechanical Engineering at Northwestern University, USA. He is a member of the European Academy of Arts and Sciences, and Fellow of AAM, ASME, and SEM. He served as Editor-in-chief of the Journal of Experimental Mechanics and Associate Editor of the Journal of Applied Mechanics. Currently, he is a co-editor of the Wiley Book Series in Micro and Nanotechnologies and serves in several journal editorial boards. His research interests include biomimetics, size scale electro-mechanical properties of nanomaterials, NEMS, in-situ microscopy testing of nanostructures, and the development of microdevices for tip-based nanofabrication and single cell studies. Gang Bao, Georgia Institute of Technology, USA Gang Bao is Professor of Bioengineering at the Georgia Institute of Technology, USA. His research interests include biomolecular engineering, bionanotechnology, molecular imaging and molecular biomechanics.
Inhaltsangabe
About the Editors xiii List of Contributors xv Foreword xix Series Preface xxi Preface xxiii Part One BIOLOGICAL PHENOMENA 1 Cell-Receptor Interactions 3 David Lepzelter and Muhammad Zaman 1.1 Introduction 3 1.2 Mechanics of Integrins 4 1.3 Two-Dimensional Adhesion 7 1.4 Two-Dimensional Motility 9 1.5 Three-Dimensional Adhesion 11 1.6 Three-Dimensional Motility 12 1.7 Apoptosis and Survival Signaling 13 1.8 Cell Differentiation Signaling 13 1.9 Conclusions 14 References 15 2 Regulatory Mechanisms of Kinesin and Myosin Motor Proteins: Inspiration for Improved Control of Nanomachines 19 Sarah Rice 2.1 Introduction 19 2.2 Generalized Mechanism of Cytoskeletal Motors 19 2.3 Switch I: A Controller of Motor Protein and G Protein Activation 21 2.4 Calcium-Binding Regulators of Myosins and Kinesins 23 2.5 Phospho-Regulation of Kinesin and Myosin Motors 262.6 Cooperative Action of Kinesin and Myosin Motors as a "Regulator" 28 2.7 Conclusion 29 References 30 3 Neuromechanics: The Role of Tension in Neuronal Growth and Memory 35 Wylie W. Ahmed, Jagannathan Rajagopalan, Alireza Tofangchi, and Taher A. Saif 3.1 Introduction 35 3.2 Tension in Neuronal Growth 41 3.3 Tension in Neuron Function 48 3.4 Modeling the Mechanical Behavior of Axons 52 3.5 Outlook 58 References 58 Part Two NANOSCALE PHENOMENA 4 Fundamentals of Roughness-Induced Superhydrophobicity 65 Neelesh A. Patankar 4.1 Background and Motivation 65 4.2 Thermodynamic Analysis: Classical Problem (Hydrophobic to Superhydrophobic) 67 4.3 Thermodynamic Analysis: Classical Problem (Hydrophilic to Superhydrophobic) 84 4.4 Thermodynamic Analysis: Vapor Stabilization 86 4.5 Applications and Future Challenges 90 Acknowledgments 91 References 91 5 Multiscale Experimental Mechanics of Hierarchical Carbon-Based Materials 95 Horacio D. Espinosa, Tobin Filleter, and Mohammad Naraghi 5.1 Introduction 95 5.2 Multiscale Experimental Tools 97 5.3 Hierarchical Carbon-Based Materials 106 5.4 Concluding Remarks 120 References 123 6 Mechanics of Nanotwinned Hierarchical Metals 129 Xiaoyan Li and Huajian Gao 6.1 Introduction and Overview 129 6.2 Microstructural Characterization and Mechanical Properties of Nanotwinned Materials 134 6.3 Deformation Mechanisms in Nanotwinned Metals 145 6.4 Concluding Remarks 156 References 157 7 Size-Dependent Strength in Single-Crystalline Metallic Nanostructures 163 Julia R. Greer 7.1 Introduction 163 7.2 Background 164 7.3 Sample Fabrication 170 7.4 Uniaxial Deformation Experiments 175 7.5 Discussion and Outlook on Size-Dependent Strength in Single-Crystalline Metals 178 7.6 Conclusions and Outlook 184 References 185 Part Three EXPERIMENTATION 8 In-Situ TEM Electromechanical Testing of Nanowires and Nanotubes 193 Horacio D. Espinosa, Rodrigo A. Bernal, and Tobin Filleter 8.1 Introduction 193 8.2 In-Situ TEM Experimental Methods 197 8.3 Capabilities of In-Situ TEM Applied to One-Dimensional Nanostructures 212 8.4 Summary and Outlook 220 Acknowledgments 221 References 221 9 Engineering Nano-Probes for Live-Cell Imaging of Gene Expression 227 Gang Bao, Brian Wile, and Andrew Tsourkas 9.1 Introduction 227 9.2 Molecular Probes for RNA Detection 229 9.3 Probe Design, Imaging, and Biological Issues 239 9.4 Delivery of Molecular Beacons 244 9.5 Engineering Challenges and Future Directions 248 Acknowledgments 249 References 249 10 Towards High-Throughput Cell Mechanics Assays for Research and Clinical Applications 255 David R. Myers, Daniel A. Fletcher, and Wilbur A. Lam 10.1 Cell Mechanics Overview 255 10.2 Bulk Assays 262 10.3 Single-Cell Techniques 268 10.4 Existing High-Throughput Cell Mechanical-Based Assays 274 10.5 Cell Mechanical Properties and Diseases 280 References 284 11 Microfabricated Technologies for Cell Mechanics Studies 293 Sri Ram K. Vedula, Man C. Leong, and Chwee T. Lim 11.1 Introduction 293 11.2 Microfabrication Techniques 294 11.3 Applications to Cell Mechanics 298 11.4 Conclusions 307 References 307 Part Four MODELING 12 Atomistic Reaction Pathway Sampling: The Nudged Elastic BandMethod and Nanomechanics Applications 313 Ting Zhu, Ju Li, and Sidney Yip 12.1 Introduction 313 12.2 The NEB Method for Stress-Driven Problems 315 12.3 Nanomechanics Case Studies 324 12.4 A Perspective on Microstructure Evolution at Long Times 332 References 336 13 Mechanics of Curvilinear Electronics 339 Shuodao Wang, Jianliang Xiao, Jizhou Song, Yonggang Huang, and John A. Rogers 13.1 Introduction 339 13.2 Deformation of Elastomeric Transfer Elements during Wrapping Processes 342 13.3 Buckling of Interconnect Bridges 347 13.4 Maximum Strain in the Circuit Mesh 351 13.5 Concluding Remarks 355 Acknowledgments 355 References 355 14 Single-Molecule Pulling: Phenomenology and Interpretation 359 Ignacio Franco, Mark A. Ratner, and George C. Schatz 14.1 Introduction 359 14.2 Force-Extension Behavior of Single Molecules 360 14.3 Single-Molecule Thermodynamics 364 14.4 Modeling Single-Molecule Pulling Using Molecular Dynamics 370 14.5 Interpretation of Pulling Phenomenology 376 14.6 Summary 384 Acknowledgments 385 References 385 15 Modeling and Simulation of Hierarchical Protein Materials 389 Tristan Giesa, Graham Bratzel, and Markus J. Buehler 15.1 Introduction 389 15.2 Computational and Theoretical Tools 391 15.3 Case Studies 400 15.4 Discussion and Conclusion 406 Acknowledgments 406 References 406 16 Geometric Models of Protein Secondary-Structure Formation 411 Hendrik Hansen-Goos and Seth Lichter 16.1 Introduction 411 16.2 Hydrophobic Effect 412 16.3 Prior Numerical and Coarse-Grained Models 415 16.4 Geometry-Based Modeling: The Tube Model 416 16.5 Morphometric Approach to Solvation Effects 422 16.6 Discussion, Conclusions, Future Work 429 Acknowledgments 433 References 433 17 Multiscale Modeling for the Vascular Transport of Nanoparticles 437 Shaolie S. Hossain, Adrian M. Kopacz, Yongjie Zhang, Sei-Young Lee, Tae-Rin Lee, Mauro Ferrari, Thomas J.R. Hughes, Wing Kam Liu, and Paolo Decuzzi 17.1 Introduction 437 17.2 Modeling the Dynamics of NPs in the Macrocirculation 438 17.3 Modeling the NP Dynamics in the Microcirculation 448 17.4 Conclusions 456 Acknowledgments 456 References 457 Index 461
About the Editors xiii List of Contributors xv Foreword xix Series Preface xxi Preface xxiii Part One BIOLOGICAL PHENOMENA 1 Cell-Receptor Interactions 3 David Lepzelter and Muhammad Zaman 1.1 Introduction 3 1.2 Mechanics of Integrins 4 1.3 Two-Dimensional Adhesion 7 1.4 Two-Dimensional Motility 9 1.5 Three-Dimensional Adhesion 11 1.6 Three-Dimensional Motility 12 1.7 Apoptosis and Survival Signaling 13 1.8 Cell Differentiation Signaling 13 1.9 Conclusions 14 References 15 2 Regulatory Mechanisms of Kinesin and Myosin Motor Proteins: Inspiration for Improved Control of Nanomachines 19 Sarah Rice 2.1 Introduction 19 2.2 Generalized Mechanism of Cytoskeletal Motors 19 2.3 Switch I: A Controller of Motor Protein and G Protein Activation 21 2.4 Calcium-Binding Regulators of Myosins and Kinesins 23 2.5 Phospho-Regulation of Kinesin and Myosin Motors 262.6 Cooperative Action of Kinesin and Myosin Motors as a "Regulator" 28 2.7 Conclusion 29 References 30 3 Neuromechanics: The Role of Tension in Neuronal Growth and Memory 35 Wylie W. Ahmed, Jagannathan Rajagopalan, Alireza Tofangchi, and Taher A. Saif 3.1 Introduction 35 3.2 Tension in Neuronal Growth 41 3.3 Tension in Neuron Function 48 3.4 Modeling the Mechanical Behavior of Axons 52 3.5 Outlook 58 References 58 Part Two NANOSCALE PHENOMENA 4 Fundamentals of Roughness-Induced Superhydrophobicity 65 Neelesh A. Patankar 4.1 Background and Motivation 65 4.2 Thermodynamic Analysis: Classical Problem (Hydrophobic to Superhydrophobic) 67 4.3 Thermodynamic Analysis: Classical Problem (Hydrophilic to Superhydrophobic) 84 4.4 Thermodynamic Analysis: Vapor Stabilization 86 4.5 Applications and Future Challenges 90 Acknowledgments 91 References 91 5 Multiscale Experimental Mechanics of Hierarchical Carbon-Based Materials 95 Horacio D. Espinosa, Tobin Filleter, and Mohammad Naraghi 5.1 Introduction 95 5.2 Multiscale Experimental Tools 97 5.3 Hierarchical Carbon-Based Materials 106 5.4 Concluding Remarks 120 References 123 6 Mechanics of Nanotwinned Hierarchical Metals 129 Xiaoyan Li and Huajian Gao 6.1 Introduction and Overview 129 6.2 Microstructural Characterization and Mechanical Properties of Nanotwinned Materials 134 6.3 Deformation Mechanisms in Nanotwinned Metals 145 6.4 Concluding Remarks 156 References 157 7 Size-Dependent Strength in Single-Crystalline Metallic Nanostructures 163 Julia R. Greer 7.1 Introduction 163 7.2 Background 164 7.3 Sample Fabrication 170 7.4 Uniaxial Deformation Experiments 175 7.5 Discussion and Outlook on Size-Dependent Strength in Single-Crystalline Metals 178 7.6 Conclusions and Outlook 184 References 185 Part Three EXPERIMENTATION 8 In-Situ TEM Electromechanical Testing of Nanowires and Nanotubes 193 Horacio D. Espinosa, Rodrigo A. Bernal, and Tobin Filleter 8.1 Introduction 193 8.2 In-Situ TEM Experimental Methods 197 8.3 Capabilities of In-Situ TEM Applied to One-Dimensional Nanostructures 212 8.4 Summary and Outlook 220 Acknowledgments 221 References 221 9 Engineering Nano-Probes for Live-Cell Imaging of Gene Expression 227 Gang Bao, Brian Wile, and Andrew Tsourkas 9.1 Introduction 227 9.2 Molecular Probes for RNA Detection 229 9.3 Probe Design, Imaging, and Biological Issues 239 9.4 Delivery of Molecular Beacons 244 9.5 Engineering Challenges and Future Directions 248 Acknowledgments 249 References 249 10 Towards High-Throughput Cell Mechanics Assays for Research and Clinical Applications 255 David R. Myers, Daniel A. Fletcher, and Wilbur A. Lam 10.1 Cell Mechanics Overview 255 10.2 Bulk Assays 262 10.3 Single-Cell Techniques 268 10.4 Existing High-Throughput Cell Mechanical-Based Assays 274 10.5 Cell Mechanical Properties and Diseases 280 References 284 11 Microfabricated Technologies for Cell Mechanics Studies 293 Sri Ram K. Vedula, Man C. Leong, and Chwee T. Lim 11.1 Introduction 293 11.2 Microfabrication Techniques 294 11.3 Applications to Cell Mechanics 298 11.4 Conclusions 307 References 307 Part Four MODELING 12 Atomistic Reaction Pathway Sampling: The Nudged Elastic BandMethod and Nanomechanics Applications 313 Ting Zhu, Ju Li, and Sidney Yip 12.1 Introduction 313 12.2 The NEB Method for Stress-Driven Problems 315 12.3 Nanomechanics Case Studies 324 12.4 A Perspective on Microstructure Evolution at Long Times 332 References 336 13 Mechanics of Curvilinear Electronics 339 Shuodao Wang, Jianliang Xiao, Jizhou Song, Yonggang Huang, and John A. Rogers 13.1 Introduction 339 13.2 Deformation of Elastomeric Transfer Elements during Wrapping Processes 342 13.3 Buckling of Interconnect Bridges 347 13.4 Maximum Strain in the Circuit Mesh 351 13.5 Concluding Remarks 355 Acknowledgments 355 References 355 14 Single-Molecule Pulling: Phenomenology and Interpretation 359 Ignacio Franco, Mark A. Ratner, and George C. Schatz 14.1 Introduction 359 14.2 Force-Extension Behavior of Single Molecules 360 14.3 Single-Molecule Thermodynamics 364 14.4 Modeling Single-Molecule Pulling Using Molecular Dynamics 370 14.5 Interpretation of Pulling Phenomenology 376 14.6 Summary 384 Acknowledgments 385 References 385 15 Modeling and Simulation of Hierarchical Protein Materials 389 Tristan Giesa, Graham Bratzel, and Markus J. Buehler 15.1 Introduction 389 15.2 Computational and Theoretical Tools 391 15.3 Case Studies 400 15.4 Discussion and Conclusion 406 Acknowledgments 406 References 406 16 Geometric Models of Protein Secondary-Structure Formation 411 Hendrik Hansen-Goos and Seth Lichter 16.1 Introduction 411 16.2 Hydrophobic Effect 412 16.3 Prior Numerical and Coarse-Grained Models 415 16.4 Geometry-Based Modeling: The Tube Model 416 16.5 Morphometric Approach to Solvation Effects 422 16.6 Discussion, Conclusions, Future Work 429 Acknowledgments 433 References 433 17 Multiscale Modeling for the Vascular Transport of Nanoparticles 437 Shaolie S. Hossain, Adrian M. Kopacz, Yongjie Zhang, Sei-Young Lee, Tae-Rin Lee, Mauro Ferrari, Thomas J.R. Hughes, Wing Kam Liu, and Paolo Decuzzi 17.1 Introduction 437 17.2 Modeling the Dynamics of NPs in the Macrocirculation 438 17.3 Modeling the NP Dynamics in the Microcirculation 448 17.4 Conclusions 456 Acknowledgments 456 References 457 Index 461
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