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Genomes 4 has beencompletely revised and updated. Itis a thoroughly moderntextbook aboutgenomes and how they are investigated.As with Genomes 3, techniques come first, then genome anatomies, followed by genome function, and finally genome evolution.The genomes of all types of organism are covered: viruses, bacteria, fungi, plants, and animals including humans and other hominids. Genome sequencing and assembly methods have been thoroughly revised including a survey of four genome projects: human, Neanderthal, giant panda, and barley. Coverage of genome annotation emphasizes genome-wide RNA…mehr

Produktbeschreibung
Genomes 4 has beencompletely revised and updated. Itis a thoroughly moderntextbook aboutgenomes and how they are investigated.As with Genomes 3, techniques come first, then genome anatomies, followed by genome function, and finally genome evolution.The genomes of all types of organism are covered: viruses, bacteria, fungi, plants, and animals including humans and other hominids. Genome sequencing and assembly methods have been thoroughly revised including a survey of four genome projects: human, Neanderthal, giant panda, and barley. Coverage of genome annotation emphasizes genome-wide RNA mapping, with CRISPR-Cas 9 and GWAS methods of determining gene function covered.The knowledge gained fromthese techniques forms the basis of the three chapters that describe the three main types of genomes: eukaryotic, prokaryotic (including eukaryotic organelles), and viral (including mobile genetic elements). Coverage of genome expression and replicationis truly genomic, concentrating on the genome-wide implications of DNA packaging, epigenome modifications, DNA-binding proteins, non-coding RNAs, regulatory genome sequences, and protein-protein interactions. Also included are applications of transcriptome analysis, metabolomics, and systems biology. The final chapter is on genome evolution, focusing on the evolution of the epigenome, using genomics to study human evolution, and using population genomics to advance plant breeding. Establishedmethods of molecular biology are included if they are still relevant today and there is always an explanation as to why the method is still important. Each chapter has a set of short-answer questions, in-depth problems, and annotated further reading. There is also an extensive glossary. Genomes 4 isthe ideal text for upper level courses focused on genomes and genomics.
  • Produktdetails
  • Verlag: Taylor & Francis
  • Artikelnr. des Verlages: Y153573
  • 4., Neuausg.
  • Seitenzahl: 520
  • Erscheinungstermin: 13. Mai 2017
  • Englisch
  • Abmessung: 274mm x 212mm x 30mm
  • Gewicht: 1106g
  • ISBN-13: 9780815345084
  • ISBN-10: 0815345089
  • Artikelnr.: 48123351
Autorenporträt
Terry Brown is professor of Biomolecular Archaeology at Manchester University. As well as writing the previous editions of Genomes, he is the author of Introduction to Genetics: A Molecular Approach (Garland 2011) and 5 editions of DNA Cloning & Analysis (Wiley Blackwell). He is also an experienced teacher of genetics.
Inhaltsangabe
PART 1 HOW GENOMES ARE STUDIED1. Genomes, Transcriptomes and Proteomes2. Studying DNA3. Mapping Genomes4. Sequencing Genomes5. Genome Annotation6. Identifying Gene FunctionsPART 2 GENOME ANATOMIES7. Eukaryotic Nuclear Genomes8. Genomes of Prokaryotes and Eukaryotic Organelles9. Virus Genomes and Mobile Genetic ElementsPART 3 HOW GENOMES ARE EXPRESSED10. Accessing the Genome11. The Role of DNA-Protein Interactions in Genome Expression12. Transcriptomes13. Proteomes14. Genome Expression in the Context of Cell and OrganismPART 4 HOW GENOMES ARE REPLICATED AND EVOLVE15. Genome Replication16. Mutations and DNA Repair17. Recombination and Transposition18. How Genomes Evolve