The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease.…mehr
The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease.
General introduction, Riekelt H. Houtkooper.- Biochemistry and Enzymology of Sirtuins, Yue Yang and Anthony A. Sauve.- NAD+ as a pharmacological tool to boost sirtuin activity, Riekelt H. Houtkooper.- Protein lysine acylation: abundance, dynamics and function, Olga Pougovkina and Vincent C. J. de Boer.- SIRT1 in metabolic health and disease, Marie Boutant and Carles Cantó.- Deacetylation by SIRT3 relieves inhibition of mitochondrial protein function, Peter Chhoy, Kristin A. Anderson, Kathleen A. Hershberger, Frank K. Huynh, Angelical S. Martin, Eoin McDonnell, Brett S. Peterson, Laura A. Starzenski, Donald S. Backos, Kristofer S. Fritz, and Matthew D. Hirschey.- SIRT5 reveals novel enzymatic activities of sirtuins, Bin He and Hening Lin.- Diverse roles for SIRT6 in mammalian healthspan and longevity, Bernadette M. M. Zwaans, William Giblin and David B. Lombard.- Sirtuins in cancer - emerging role as modulators of metabolic reprogramming, Jaewon J. Lee, Karina N. Gonzalez Herrera and Marcia C. Haigis.- Sirtuins as metabolic modulators of muscle plasticity, Keir Menzies, Julien Francisco Zaldivar-Jolissaint and Johan Auwerx.- Sirtuins and aging, Carles Cantó and Riekelt Houtkooper.- Sirtuins and the Circadian Clock: Epigenetic and Metabolic Crosstalk, Selma Masri, Marina Maria Bellet and Paolo Sassone-Corsi.- Sirtuin activation by small molecules, Hassina Massudi, Lindsay E. Wu, and David A. Sinclair.- Future perspective, Brian Kennedy.- Index.
General introduction, Riekelt H. Houtkooper.- Biochemistry and Enzymology of Sirtuins, Yue Yang and Anthony A. Sauve.- NAD+ as a pharmacological tool to boost sirtuin activity, Riekelt H. Houtkooper.- Protein lysine acylation: abundance, dynamics and function, Olga Pougovkina and Vincent C. J. de Boer.- SIRT1 in metabolic health and disease, Marie Boutant and Carles Cantó.- Deacetylation by SIRT3 relieves inhibition of mitochondrial protein function, Peter Chhoy, Kristin A. Anderson, Kathleen A. Hershberger, Frank K. Huynh, Angelical S. Martin, Eoin McDonnell, Brett S. Peterson, Laura A. Starzenski, Donald S. Backos, Kristofer S. Fritz, and Matthew D. Hirschey.- SIRT5 reveals novel enzymatic activities of sirtuins, Bin He and Hening Lin.- Diverse roles for SIRT6 in mammalian healthspan and longevity, Bernadette M. M. Zwaans, William Giblin and David B. Lombard.- Sirtuins in cancer - emerging role as modulators of metabolic reprogramming, Jaewon J. Lee, Karina N. Gonzalez Herrera and Marcia C. Haigis.- Sirtuins as metabolic modulators of muscle plasticity, Keir Menzies, Julien Francisco Zaldivar-Jolissaint and Johan Auwerx.- Sirtuins and aging, Carles Cantó and Riekelt Houtkooper.- Sirtuins and the Circadian Clock: Epigenetic and Metabolic Crosstalk, Selma Masri, Marina Maria Bellet and Paolo Sassone-Corsi.- Sirtuin activation by small molecules, Hassina Massudi, Lindsay E. Wu, and David A. Sinclair.- Future perspective, Brian Kennedy.- Index.
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