Sirtuins (eBook, PDF)
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The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease.…mehr

Produktbeschreibung
The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease.

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  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Erscheinungstermin: 17.11.2016
  • Englisch
  • ISBN-13: 9789402409628
  • Artikelnr.: 53149982
Inhaltsangabe
General introduction Riekelt H. Houtkooper
Biochemistry and Enzymology of Sirtuins Yue Yang and Anthony A. Sauve
NAD+ as a pharmacological tool to boost sirtuin activity Riekelt H. Houtkooper
Protein lysine acylation: abundance, dynamics and function Olga Pougovkina and Vincent C. J. de Boer
SIRT1 in metabolic health and disease Marie Boutant and Carles Cantó
Deacetylation by SIRT3 relieves inhibition of mitochondrial protein function Peter Chhoy, Kristin A. Anderson, Kathleen A. Hershberger, Frank K. Huynh, Angelical S. Martin, Eoin McDonnell, Brett S. Peterson, Laura A. Starzenski, Donald S. Backos, Kristofer S. Fritz, and Matthew D. Hirschey
SIRT5 reveals novel enzymatic activities of sirtuins Bin He and Hening Lin
Diverse roles for SIRT6 in mammalian healthspan and longevity Bernadette M. M. Zwaans, William Giblin and David B. Lombard
Sirtuins in cancer - emerging role as modulators of metabolic reprogramming Jaewon J. Lee, Karina N. Gonzalez Herrera and Marcia C. Haigis
Sirtuins as metabolic modulators of muscle plasticity Keir Menzies, Julien Francisco Zaldivar-Jolissaint and Johan Auwerx
Sirtuins and aging Carles Cantó and Riekelt Houtkooper
Sirtuins and the Circadian Clock: Epigenetic and Metabolic Crosstalk Selma Masri, Marina Maria Bellet and Paolo Sassone-Corsi
Sirtuin activation by small molecules Hassina Massudi, Lindsay E. Wu, and David A. Sinclair
Future perspective Brian Kennedy
Index