Molecular and Biochemical Toxicology (eBook, ePUB)

Redaktion: Smart, Robert C.; Hodgson, Ernest

• Format: ePub

Produktbeschreibung

An essential resource for graduate students, academic andindustrial toxicologists, and environmental health scientists andprofessionals Over the course of thirty years and three editions,Introduction to Biochemical Toxicology has been an importantsource for coverage of the ongoing quest to define the biochemical,cellular, and molecular events induced by toxicants at the cellularand organismic levels. Now, as the principles and methods ofmolecular and cellular biology as well as genomic sciences play anever increasing role in mechanistic toxicology, significant changeshave been made to the book, resulting in this important newedition-now titled Molecular and Biochemical Toxicology,Fourth Edition. Much more than an introductory text, this crucial new editionhas been completely revised to provide timely and thorough coverageof the underlying biochemical, molecular, and cellular mechanismsthrough which toxicants produce their adverse effects.Toxicological issues are covered from the molecule to the cell tothe organ level. Complex methods used in toxicology are alsodescribed in a straightforward, easy-to-understand style.Additional features of this new edition include: * New chapters that explore the interface between toxicology andgenomic sciences, including: bioinformatics, proteomics,metabolomics, and toxicogenomics * Increased emphasis on structure, mechanism, and regulation ofxenobiotic metabolizing enzymes, toxicogenetics, and xenobiotictransporters * Additional new chapters on: molecular epidemiology and geneticsusceptibility, DNA damage and mutagenesis, DNA repair, mechanismsof cell death, mitochondrial dysfunction, metals, reproductivetoxicology, developmental toxicology, and reactiveoxygen/metabolites and toxicity Molecular and Biochemical Toxicology, Fourth Editionguides graduate students, toxicologists, and environmental healthprofessionals through the principles of molecular and biochemicaltoxicology and the complex mechanisms of toxicity. Whether it'sused in the classroom or in industry, research, or academia, thisbook is essential for anyone interested in understanding themolecular mechanisms through which toxicants produce adverseeffects.

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 944
• Erscheinungstermin: 5. März 2013
• Englisch
• ISBN-13: 9781118679722
• Artikelnr.: 37758331

Autorenporträt

Robert C. Smart, PhD, is a Professor in the Department of Environmental and Molecular Toxicology at North Carolina State University. Together with Dr. Hodgson, he coedited the previous edition of this book.

Ernest Hodgson, PhD, is the William Neal Reynolds Professor of Toxicology at North Carolina State University. He edited A Textbook of Modern Toxicology, Third Edition (Wiley) and is the Editor of the Journal of Biochemical and Molecular Toxicology.

Inhaltsangabe

Preface.

Contributors.

1. Molecular and Biochemical Toxicology: Definition and Scope (Ernest Hodgson and Robert C. Smart).

Suggested Reading.

2. Overview of Molecular Techniques in Toxicology: Genes and Transgenes (Robert C. Smart).

3. Toxicogenomics (Marjorie F. Oleksiak).

4. Proteomics (B. Alex Merrick).

5. Metabolomics (Nigel Deighton).

6. Bioinformatics (Eric A. Stone and Dahlia M. Nielsen).

7 Immunochemical Techniques in Toxicology (Gerald A. LeBlanc).

8. Cellular Techniques (Sharon A. Meyer).

9. Structure, Mechanism and Regulation of Cytochromes P450 (Darryl C. Zeldin and John M. Seubert).

10. Phase I Metabolism of Toxicants and Metabolic Interactions (Ernest Hodgson, Parikshit C. Das, Taehyeon M. Cho and Randy L. Rose).

11. Phase I Pharmacogenetics (Ernest Hodgson and Edward L. Croom).

12. Phase II - Conjugation of Toxicants (Gerald A. LeBlanc).

13. Regulation and Polymorphisms in Phase II Genes (Yoshiaki Tsuji).

14. Developmental Effects on Xenobiotic Metabolism (Martin J. J. Ronis and Helen C. Cunny).

15. Cellular Transport and Elimination (David S. Miller).

16. Mechanisms of Cell Death (Mac Law and Susan Elmore).

17. Mitochondrial Dysfunction (Jun Ninomiya-Tsuji).

18. Glutathione-Dependent Mechanisms in Chemically Induced Cell Injury and Cellular Protection Mechanisms (Donald J. Reed).

19. Toxicant-Receptor Interactions: Fundamental Principles (Richard B. Mailman).

20. Reactive Oxygen/Metabolites and Toxicity (Elizabeth L. MacKenzie).

21. Metals (David B. Buchwalter).

22. DNA Damage and Mutagenesis (Zhigang Wang).

23. DNA Repair (Isabel Mellon).

24. Carcinogenesis (Robert C. Smart, Sarah J. Ewing and Kari D. Loomis).

25. Genetic Toxicology (R. Julian Preston).

26. Molecular Epidemiology and Genetic Susceptibility (Ruth M. Lunn and Marianna Stern).

27. Respiratory Toxicology (James C. Bonner).

28. Hepatotoxicity (Andrew D. Wallace and Sharon A. Meyer).

29. Biochemical Mechanisms of Renal Toxicity (Joan B. Tarloff and Andrew D. Wallace).

30. Biochemical Toxicology of the Peripheral Nervous System (Jeffry F. Goodrum, Arrel D. Toews and Thomas W. Bouldin).

31. Biochemical Toxicology of the Central Nervous System (Bonita L. Blake).

32. Immunotoxicology (MaryJane K. Selgrade, Dori R. Germolec, Robert W. Luebke, Ralph J. Smialowicz, Marsha D. Ward and Christal C. Bowman).

33. Reproductive Toxicology (John F. Couse).

34. Developmental Toxicology (John F. Couse).

35. Dermatotoxicology (Nancy A. Monteiro-Riviere).

Index.