Carsten Carlberg, Ferdinand Molnár

Mechanisms of Gene Regulation: How Science Works (eBook, PDF)

• Format: PDF

Produktbeschreibung

This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.

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Produktdetails

• Verlag: Springer International Publishing
• Seitenzahl: 149
• Erscheinungstermin: 29. Oktober 2020
• Englisch
• ISBN-13: 9783030523213
• Artikelnr.: 62299240

Autorenporträt

Carsten Carlberg graduated 1989 with a PhD in biochemistry at the Free University Berlin (Germany). After positions as postdoc at Roche (Basel, Switzerland), group leader at the University of Geneva (Switzerland) and docent at the University of Düsseldorf (Germany) he is since 2000 full professor of biochemistry at the University of Eastern Finland in Kuopio (Finland). His work focuses on mechanisms of gene regulation by nuclear hormones, in particular on vitamin D. At present Prof. Carlberg focuses projects on epigenome-wide effects of vitamin D on the human immune system.

Ferdinand Molnár received his PhD in biochemistry from the University of Kuopio (Kuopio, Finland) in 2006. He did his postdoctoral training in Structural Biology at the IGBMC (Illkirch, France). In 2008 he joined the School of Pharmacy at the University of Eastern Finland (Kuopio, Finland) studying nuclear receptor-ligand, - protein and -DNA interactions. In 2018 he moved to the Nazarbayev University (Nur-Sultan, Kazakhstan) where he holds an Associate Professor position at the Department of Biology. Prof. Molnár interests are integrative structural biology and bioinformatics, eukaryotic transcriptional regulation in health and disease and recombinant protein production.

Inhaltsangabe

1 Genes and chromatin1.1Central dogma of molecular biology1.2Impact of chromatin structure1.3Epigenetics enables gene expression1.4Gene regulation in the context of nuclear architecture2 Basal transcriptional machinery2.1Core promoter2.2TATA box and other core promoter elements2.3Genome-wide core promoter identification2.4TFIID and Mediator as paradigms of multi-protein complexes3 Transcription factors and signal transduction3.1Site-specific transcription factors and their domains3.2Classification of transcription factors3.3.Activation of transcription factors3.4Programing cellular differentiation by transcription factors3.5Inflammatory signaling via NF- B3.6Sensing cellular stress via p534 A key transcription factor family: Nuclear receptors4.1The nuclear receptor superfamily4.2Molecular interactions of nuclear receptors4.3Physiological role of nuclear receptors5 Genome-wide principles of gene regulation5.1Next-generation sequencing5.2Gene regulation in the context of Big Biology5.3Exploring genome-wide transcription factor binding5.4Integrating epigenome-wide datasets6 Chromatin modifiers6.1Cytosines and their methylation6.2Histone modifications6.3Gene regulation via chromatin modifiers6.4Sensing energy metabolism via chromatin modifiers7 Epigenetics7.1Epigenetics and chromatin7.2Genome-wide understanding of epigenetics7.3CTCF and genetic imprinting7.4Epigenetics in health and disease8 Chromatin remodeling and organization8.1Nucleosome positioning at promoters8.2Chromatin remodeling8.3Transcriptional dynamics in the presence of chromatin8.4Organization of the nucleus9 Regulatory impact of non-coding RNA9.1Non-coding RNAs9.2miRNAs and their regulatory potential9.3Long ncRNAs9.4Enhancer RNAs