Biological Chemistry of Arsenic, Antimony and Bismuth (eBook, ePUB)

Redaktion: Sun, Hongzhe

• Format: ePub

Produktbeschreibung

Arsenic, antimony and bismuth, three related elements of group 15, are all found in trace quantities in nature and have interesting biological properties and uses. While arsenic is most well known as a poison - and indeed the contamination of groundwater by arsenic is becoming a major health problem in Asia - it also has uses for the treatment of blood cancer and has long been used in traditional chinese medicine. Antimony and bismuth compounds are used in the clinic for the treatment of parasitic and bacterial infections. Biological Chemistry of Arsenic, Antimony and Bismuth is an essential overview of the biological chemistry of these three elements, with contributions from an international panel of experts. Topics covered include: * chemistry of As, Sb and Bi * biological chemistry of arsenic * biological chemistry of Sb and Bi * arsenic and antimony speciation in environmental and biological samples * arsenic in traditional chinese medicine * arsenic in aquifers * biomethylation of As, Sb and Bi * uptake of metalloids by cells * bismuth complexes of porphyrins and their potential in medical applications * Helicobacter pylori and bismuth * metabolism of arsenic trioxide in blood of the acute promyelocytic leukemia patients * anticancer properties of As, Sb and Bi * radio-Bi in cancer therapy * genotoxicity of As, Sb and Bi * metallomics as a new technique for As, Sb and Bi * metalloproteomics for As, Sb and Bi Biological Chemistry of Arsenic, Antimony and Bismuth conveys the essential aspects of the bioinorganic chemistry of these three elements, making this book a valuable complement to more general bioinorganic chemistry texts and more specialized topical reviews. It will find a place on the bookshelves of practitioners, researchers and students working in bioinorganic chemistry and medicinal chemistry.

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 400
• Erscheinungstermin: 22. November 2010
• Englisch
• ISBN-13: 9780470976227
• Artikelnr.: 37301094

Autorenporträt

Dr Hongzhe Sun, Department of Chemistry, The University of Hong Kong Dr. Sun's research interests lie in the chemistry of metals in biology and medicine. He has been invited to deliver lectures in various international conferences including the prestigious "Gordon Conference on Metals in Medicine" and "International Conference on Biological Inorganic Chemistry". He has published over 80 papers in solid chemical and biochemical journals. He serves in the Editorial Advisory Board of The Journal of Biological Inorganic Chemistry (Springer, 2007-2009) and The Open Medicinal Chemistry Journal (Bentham Science Publisher).

Inhaltsangabe

List of Contributors. Preface. 1 The Chemistry of Arsenic, Antimony and
Bismuth (Neil Burford, Yuen-ying Carpenter, Eamonn Conrad and Cheryl D.L.
Saunders). 1.1 Properties of the Elements. 1.2 Allotropes. 1.3 Bond
Energies. 1.4 Oxidation States. 1.5 Relativistic Effects and Orbital
Contraction. 1.6 Structure and Bonding. 1.7 Clusters and Extended
Structures. 1.8 Hybridization and Inversion. 1.9 Coordination Chemistry.
1.10 Geological Occurrence. 1.11 Aqueous Chemistry and Speciation. 1.12
Analytical Methods and Characterization. 1.13 Conclusions. 2 Arsenic's
Interactions with Macromolecules and its Relationship to Carcinogenesis
(Kirk T. Kitchin). 2.1 Introduction. 2.2 Arsenic's Interactions with DNA
and Proteins. 2.3 Cancer - MOA. 2.4 Arsenic's Many Connections to
Carcinogenesis. 2.5 Sources of Information on Arsenic's Mode of Action,
Biochemical Effects, Carcinogenesis in Animals and Man, Metabolism and
Analytical Chemistry. 2.6 Conclusion. 3 Biological Chemistry of Antimony
and Bismuth (Nan Yang and Hongzhe Sun). 3.1 Introduction. 3.2 Biorelevant
Coordination Chemistry of Antimony and Bismuth. 3.3 Antimony and Bismuth
Compounds in Medicine. 3.4 Interaction with Nucleic Acids. 3.5 Interaction
with Amino Acids and Peptides. 3.6 Interaction with Proteins and Enzymes.
3.7 Conclusion and Perspectives. 4 Metallomics Research Related to Arsenic
(Hiroki Haraguchi). 4.1 Metallomics - Integrated Biometal Science. 4.2
Analytical Feasibility of ICP-AES and ICP-MS. 4.3 Chemical Speciation of
Trace Elements in Biological Samples. 4.4 Summary. 5 Arsenic in Traditional
Chinese Medicine (Kui Wang, Siwang Yu and Tianlan Zhang). 5.1 Arsenic
Bearing Minerals and their Clinical Applications. 5.2 Metabolism and
Pharmacokinetics of Arsenic Bearing Minerals. 5.3 Pharmacological
Activities and Mechanisms of Actions of ABMs. 5.4 Perspectives. 6 Microbial
Transformations of Arsenic in Aquifers (Jonathan R. Lloyd). 6.1 An
Introduction to the Microbial Cycling of Arsenic. 6.2 The Biochemistry of
Microbial Arsenic Transformations. 6.3 Microbially Driven Mobilization of
Arsenic in Aquifers: a Humanitarian Disaster. 6.4 Conclusions and Future
Directions. 7 Biomethylation of Arsenic, Antimony and Bismuth (Richard O.
Jenkins). 7.1 Introduction. 7.2 Biomethylation of Arsenic. 7.3
Biomethylation of Antimony. 7.4 Biomethylation of Bismuth. 8 Metalloid
Transport Systems (Hsueh-Liang Fu, Xuan Jiang and Barry P. Rosen). 8.1
Introduction. 8.2 Metalloid Uptake Systems. 8.3 Metalloid Efflux Systems.
8.4 Summary and Conclusions. 9 Bismuth Complexes of Porphyrins and their
Potential in Medical Applications (Bernard Boitrel). 9.1 Introduction. 9.2
Early Work (1969-1994). 9.3 Bismuth Complexes of Unfunctionalized
Porphyrins. 9.4 Bismuth Complexes of Functionalized Porphyrins. 9.5 Future
Strategies Towards Bifunctional Chelates (BFC) - Conclusions. 10
Helicobacter pylori and Bismuth (Aruni H.W. Mendis and Barry J. Marshall).
10.1 Introduction. 10.2 Helicobacter pylori. 10.3 Bismuth as an
Antimicrobial Agent. 10.4 Mechanism of Action of Bismuth Citrate and CBS on
H. pylori and Ulcer Healing. 10.5 In Vitro Susceptibility of H. pylori and
other Bacteria to Bismuth Compounds and Antibiotics. 10.6 The Effect of pH
on Bactericidal Activity of Bismuth Compounds. 10.7 Novel Preparations of
Bismuth Compounds. 10.8 Novel Delivery Systems for Bismuth Compounds and
Other Antibiotics. 10.9 The Biochemical Targets of Bismuth. 10.10 Binding
of Bismuth Compounds to Plasma Proteins. 11 Application of Arsenic Trioxide
Therapy for Patients with Leukaemia (Bo Yuan, Yuta Yoshino, Toshikazu Kaise
and Hiroo Toyoda). 11.1 Introduction. 11.2 Cellular and Molecular
Mechanisms of ATO Actions. 11.3 Pharmacokinetics of ATO in APL Patients.
11.4 Potential Combination Therapies with ATO. 11.5 Potential ATO
Application to Other Leukaemias. 11.6 Conclusion. 12 Anticancer Activity of
Molecular Compounds of Arsenic, Antimony and Bismuth (Edward R.T. Tiekink).
12.1 Introduction. 12.2 Arsenic Compounds. 12.3 Antimony Compounds. 12.4
Bismuth Compounds. 12.5 Conclusions. 13 Radiobismuth for Therapy (Martin W.
Brechbiel and Ekaterina Dadachova). 13.1 Introduction. 13.2 Targeting
Vectors. 13.3 ±-Emitters versus ²--Emitters. 13.4 Radionuclides. 13.5
Radiolabeling - Chemistry. 13.6 Preclinical Studies. 13.7 Targeted
±-Therapy versus Targeted ²-Therapy. 13.8 Clinical Studies. 13.9 Alternate
Delivery Methods and Uses. 13.10 Prospects and Conclusions. 14 Genetic
Toxicology of Arsenic and Antimony (Toby G. Rossman and Catherine B.
Klein). 14.1 Introduction. 14.2 DNA Damage in Cells Treated with
Arsenicals. 14.3 Mutagenesis in Cells Treated with Arsenicals. 14.4 Other
Genotoxic Events in Cells Treated with Arsenicals. 14.5 Effects of
Arsenicals on DNA Repair. 14.6 Indirect Mechanisms of Mutagenicity and
Comutagenicity by Arsenicals. 14.7 Mutagenesis and Transformation as
Secondary Effects of Genomic Instability. 14.8 Antimony. 15
Metalloproteomics of Arsenic, Antimony and Bismuth Based Drugs (Cheuk-Nam
Tsang, Ruiguang Ge and Hongzhe Sun). 15.1 Introduction. 15.2 Chemical
Speciation of Arsenic Based Drugs and their Metallometabolism. 15.3
Metalloproteomics and its Applications to As-, Sb- and Bi-Based
Metallodrugs. 15.4 Biological Regulation of Arsenic and Antimony. 15.5
Conclusions. Index.