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Advances that open new avenues in developing aminoglycosideantibiotics During the last twenty years, there have been numerous advances inthe understanding of the chemistry, biochemistry, and recognitionof aminoglycosides. This has led to the development of novelantibiotics and opened up new therapeutic targets for intervention.This is the first book to provide a complete overview of recentadvances in the field and explore their tremendous potential fordrug discovery and rational drug design. With chapters written byone or more leading experts in their specialty areas, the bookaddresses the…mehr

Produktbeschreibung
Advances that open new avenues in developing aminoglycosideantibiotics During the last twenty years, there have been numerous advances inthe understanding of the chemistry, biochemistry, and recognitionof aminoglycosides. This has led to the development of novelantibiotics and opened up new therapeutic targets for intervention.This is the first book to provide a complete overview of recentadvances in the field and explore their tremendous potential fordrug discovery and rational drug design. With chapters written byone or more leading experts in their specialty areas, the bookaddresses the chemistry, biology, and toxicology ofaminoglycosides. Aminoglycoside Antibiotics: From Chemical Biology to Drug Discoveryis a great resource for academic and industrial researchers in drugdesign and mechanism studies and for researchers studyingantibiotic resistance, antibiotic design and synthesis, and thediscovery of novel pharmaceuticals. It is also a valuable referencefor graduate students in pharmacy, pharmaceutical science,biophysics, medicinal chemistry, and chemical biology.

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  • Produktdetails
  • Verlag: John Wiley & Sons
  • Seitenzahl: 336
  • Erscheinungstermin: 30.08.2007
  • Englisch
  • ISBN-13: 9780470149669
  • Artikelnr.: 37291012
Autorenporträt
DEV P. ARYA is an Associate Professor of Chemistry and Director of the Laboratory of Medicinal Chemistry at Clemson University. He is a member of the ACS, and currently serves as the Program Chair of the Division of Carbohydrate Chemistry. His research interests lie in the development of nucleic acid targeted drugs.
Inhaltsangabe
Preface.
Contributors.
1. In the Beginning There Was Streptomycin (Julian Davies).
2. The Biochemistry and Genetics of Aminoglycoside Producers (Wolfgang Piepersberg, Khaled M. Aboshanab, Heike Schmidt-Beißner, and Udo F. Wehmeier).
3. Mechanisms of Aminoglycoside Antibiotic Resistance (Tushar Shakya and Gerard D. Wright).
4. Design, Chemical Synthesis, and Antibacterial Activity of Kanamycin and Neomycin Class Aminoglycoside Antibiotics (Jinhua Wang and Cheng-Wei Tom Chang).
5. NMR Structural Studies of Aminoglycoside: RNA Interaction (R. Andrew Marshall and Joseph D. Puglisi).
6. Structural Comparisons Between Prokaryotic and Eukaryotic Ribosomal Decoding A Sites Free and Complexed with Aminoglycosides (Jiro Kondo and Eric Westhof).
7. Binding of Antibiotics to the Aminoacyl-tRNA Site of Bacterial Ribosome (Dale Kling, Christine Chow, and Shahriar Mobashery).
8. Metalloaminoglycosides: Chemistry and Biological Relevance (Nikhil Gokhale, Anjali Patwardhan, and J. A. Cowan).
9. Adverse Effects of Aminoglycoside Therapy (Andra E. Talaska and Jochen Schacht).
10. Targeting HIV-1 RNA with Aminoglycoside Antibiotics and Their Derivatives (Lev Elson-Schwab and Yitzhak Tor).
11. Novel Targets for Aminoglycosides (Dev P. Arya, Nicholas Shaw, and Hongjuan Xi).
Index.