Robert A. Goodnow

A Handbook for DNA-Encoded Chemistry (eBook, ePUB)

Theory and Applications for Exploring Chemical Space and Drug Discovery

• Format: ePub

Produktbeschreibung

This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: * Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry * Helps chemists generate and screen novel chemical libraries of large size and quality * Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry - synthetic and analytical chemistry, molecular biology, informatics, and biochemistry * Shows medicinal and pharmaceutical chemists how to efficiently broaden available "chemical space" for drug discovery * Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 480
• Erscheinungstermin: 10. April 2014
• Englisch
• ISBN-13: 9781118832677
• Artikelnr.: 40780098

Autorenporträt

ROBERT A. GOODNOW, JR. is the Executive Director of the Chemistry Innovation Centre, Discovery Sciences at AstraZeneca and the Founder of GoodChem Consulting, LLC. He has extensive experience in drug discovery and chemistry technologies including carbohydrate, combinatorial, oligonucleotide, and analytical chemistry. Robert Goodnow has authored or coauthored nearly 100 publications and patents and has spoken extensively on the topics of drug lead finding and the outsourcing of drug discovery chemistry. He has lectured as an adjunct professor of medicinal chemistry.

Inhaltsangabe

Preface vii Acknowledgments ix Introductory Comments xi Contributors xxiii
1 Just enough knowledge... 1 Agnieszka Kowalczyk 2 A brief history of the
development of combinatorial chemistry and the emerging need for
DNA-encoded chemistry 19 Robert A. Goodnow, Jr. 3 A brief history of
DNA-encoded chemistry 45 Anthony D. Keefe 4 DN A-Compa tible Chemistry 67
Kin-Chun Luk and Alexander Lee Satz 5 Foundations of a DNA-encoded library
(DEL) 99 Alexander Lee Satz 6 EXERCISES IN THE SYNTHESIS OF DNA-ENCODED
LIBRARIES 123 Steffen P. Creaser and Raksha A. Acharya 7 the dna tag: A
Chemical gene designed for DNA-encoded libraries 153 Andrew W. Fraley 8
Analytical challenges for DNA-encoded library systems 171 George L. Perkins
and G. John Langley 9 Informatics: Functionality and architecture for
DNA-encoded library production and screening 201 John A. Feinberg and
Zhengwei Peng 10 Theoretical considerations of the application of
DNA-encoded libraries to drug discovery 213 Charles Wartchow 11 Begin with
the End in Mind: The hit-to-lead process 231 John Proudfoot 12 Enumeration
and Visualization of Large Combinatorial Chemical Libraries 247 Sung-Sau So
13 Screening Large Compound Collections 281 Stephen P. Hale 14 Reported
applications of DNA-encoded library chemistry 319 Johannes Ottl 15
Dual-Pharmacophore DNA-Encoded Chemical Libraries 349 Jörg Scheuermann and
Dario Neri 16 Hit Identification and Hit Follow-up 357 Yixin Zhang 17 Using
DNA to Program Chemical Synthesis, Discover New Reactions, and Detect
Ligand Binding 377 Lynn M. McGregor and David R. Liu 18 the changing
feasibility and economics of chemical diversity exploration with
DNA-encoded combinatorial approaches 417 Robert A. Goodnow, Jr. 19 Keeping
the promise? An outlook on DNA chemical library technology 427 Samu Melkko
and Johannes Ottl Index 435