Xenotransplantation could have an impact on at least three aspects of medicine. The first is as a means of overcoming a severe shortage of human donor organs for the treatment of organ failure. The second aspect relates to the possibility that a xenogeneic organ would not be susceptible to infection by a "human" virus and thus the xenograft might resist injury caused by such viruses. The third and, as of yet, unexplored aspect relates to a means of delivering genes for therapeutic purposes thus overcoming some of the limitations of "conventional" gene therapy.
Xenotransplantation could have an impact on at least three aspects of medicine. The first is as a means of overcoming a severe shortage of human donor organs for the treatment of organ failure. The second aspect relates to the possibility that a xenogeneic organ would not be susceptible to infection by a "human" virus and thus the xenograft might resist injury caused by such viruses. The third and, as of yet, unexplored aspect relates to a means of delivering genes for therapeutic purposes thus overcoming some of the limitations of "conventional" gene therapy.
Genetic Modification of Xenografts.- Public Health Risks - Patient vs. Society in an Emerging Field.- Cross-Species Infections.- Non-Human Primate Herpesviruses: Importance for Xenotransplantation.- Understanding Xenotransplantation Risks from Non-Human Primate Retroviruses.- Exogenous Porcine Viruses.- Swine Hepatitis E Virus: Cross-Species Infection and Risk in Xenotransplantation.- Molecular Cloning and Functional Characterization of Infectious PERVand Development of Diagnostic Tests.- Xenotransplantation-Federal Regulatory Considerations.
Genetic Modification of Xenografts.- Public Health Risks - Patient vs. Society in an Emerging Field.- Cross-Species Infections.- Non-Human Primate Herpesviruses: Importance for Xenotransplantation.- Understanding Xenotransplantation Risks from Non-Human Primate Retroviruses.- Exogenous Porcine Viruses.- Swine Hepatitis E Virus: Cross-Species Infection and Risk in Xenotransplantation.- Molecular Cloning and Functional Characterization of Infectious PERVand Development of Diagnostic Tests.- Xenotransplantation-Federal Regulatory Considerations.
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