Signalling from Internalised Growth Factor Receptors

Herausgegeben:Madshus, Inger Helene

• Gebundenes Buch

Produktbeschreibung

The book will concentrate on how growth factor receptors are down-regulated by endocytosis and intracellular trafficking. The authors will further discuss what is currently understood about the effect of cellular microenvironments on signal transduction.

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This book reviews knowledge on the interconnection of signal transduction and endocytosis/intracellular trafficking. The chapters cover knowledge obtained by using different model systems. The first chapter deals with Receptor Tyrosin Kinases (RTKs) with emphasis on the Epidermal Growth Factor Receptor (EGF receptor) and the Platelet Derived Growth Factor Receptor (PDGF receptor). The second chapter deals with the RTK c-Met and with how this RTK becomes carcinogenic. The third chapter reviews recent understanding on the mechanisms of action of the numerous fibroblast growth factors and their receptors. In the fourth chapter we learn about the trafficking of and signalling from the Growth Hormone Receptor and how this receptor is controlled by ubiquitination. The fifth chapter is devoted to the Interleukin II receptor, essential for activation of T cells. Links between ubiquitination, signalling, endocytosis, and sorting are reviewed. The last chapter discusses current views on how monoubiquitination controls both signalling and trafficking and thereby the final outcome of receptor activation.

Produktdetails

• Current Topics in Microbiology and Immunology 286
• Verlag: Springer / Springer Berlin Heidelberg / Springer, Berlin
• Artikelnr. des Verlages: 978-3-540-21038-2
• 2004
• Seitenzahl: 204
• Erscheinungstermin: 9. Juli 2004
• Englisch
• Abmessung: 241mm x 160mm x 18mm
• Gewicht: 400g
• ISBN-13: 9783540210382
• ISBN-10: 3540210385
• Artikelnr.: 14879295

Inhaltsangabe

List of Contents.- Receptor Tyrosine Kinase Signaling and Trafficking-Paradigms Revisited.- Met Receptor Dynamics and Signalling.- Signaling, Internalization, and Intracellular Activity of Fibroblast Growth Factor.- Ubiquitin System-Dependent Regulation of Growth Hormone Receptor Signal Transduction.- Clathrin-Independent Endocytosis and Signalling of Interleukin 2 Receptors IL-2R Endocytosis and Signalling.- Signaling Through Monoubiquitination.