Role of Capsaicin in Oxidative Stress and Cancer

Herausgegeben:Srivastava, Sanjay K.

• Gebundenes Buch

Produktbeschreibung

This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.

Produktdetails

• Diet and Cancer 3
• Verlag: Springer / Springer Netherlands
• Artikelnr. des Verlages: 86211917, 978-94-007-6316-6
• 2013
• Seitenzahl: 188
• Erscheinungstermin: 7. Mai 2013
• Englisch
• Abmessung: 241mm x 160mm x 15mm
• Gewicht: 462g
• ISBN-13: 9789400763166
• ISBN-10: 9400763166
• Artikelnr.: 37057077

Inhaltsangabe

Preface.- Role of capsaicin in cancer prevention.- Role of death receptors belonging to the TNF family in capsaicin-induced apoptosis of tumor cells.- Role of capsaicin in prostate cancer.- Capsaicin and the urinary bladder.- Inhibition of pancreatitis and carcinogenesis by capsaicin.- Cytochrome P450-dependent modification of capsaicinoids: pharmacological inactivation and bioactivation mechanisms.- The cancer suppressing and promoting actions of capsaicin.- Oxidative stress by capsaicin in cancer.