Cortical Deficits In Schizophrenia (eBook, PDF)
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The genetics of schizophrenia have been elusive for decades. In the past few years, a complex set of genes and gene variations that confer predisposition for schizophrenia have been identified. As each gene individually is not sufficient to trigger the disorder, it is likely there needs to be a combined presence of several predisposing factors for the disorder to take place. The past several years have been very prolific in identifying such genes, and a common theme that has emerged in this field is that these genes are important for a few common mechanisms, including brain development and the…mehr

Produktbeschreibung
The genetics of schizophrenia have been elusive for decades. In the past few years, a complex set of genes and gene variations that confer predisposition for schizophrenia have been identified. As each gene individually is not sufficient to trigger the disorder, it is likely there needs to be a combined presence of several predisposing factors for the disorder to take place. The past several years have been very prolific in identifying such genes, and a common theme that has emerged in this field is that these genes are important for a few common mechanisms, including brain development and the properties of three important brain chemicals: dopamine (of a critical role in motivation and attention), glutamate (the primary excitatory transmitter) and GABA (the main inhibitory agent in the brain). The challenge is to understand the biology of the genes and determine how they exert their influence, particularly in terms of brain development and function. This book provides an overview of recent findings. TOC:Schizophrenia-Predisposing Genes. an Overview.- Neuregulin Deficits In Schizophrenia.- Neuregulin: Genetic Animal Models.- HOMER Proteins and Schizophrenia.- Reelin and Schizophrenia.- DISC1 and Cognition.- Hippocampal Deficits. from Genes To Behavior.- Glutamate Deficits in Schizophrenia.- Cortical Metabolism In Schizophrenia.- and Prefrontal Cortical Interneurons.- Cortical Interneurons and Schizophrenia.- Developmental Animal Models: Gestational Antimitotics.- Developmental Animal Models: Neonatal Hippocampal Lesion.- Cortical and Subcortical Dopamine.- Multiple Genetic Factors Causing Cortical Dysfunction.

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  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Erscheinungstermin: 23.09.2007
  • Englisch
  • ISBN-13: 9780387743516
  • Artikelnr.: 37288135
Inhaltsangabe
Schizophrenia Genes: Searching for Common Features, Functions, and Mechanisms.- Towards a Molecular Classification of Illness: Effects of Schizophrenia Susceptibility Loci on Clinical Symptoms and Cognitive Function.- Homer: A Genetic Factor in Schizophrenia?.- Neuregulin-erbB Signaling and the Pathogenesis of Schizophrenia.- Nicotinic Cholinergic Cortical Dysfunction in Schizophrenia.- A Role for Glutamate Receptors, Transporters, and Interacting Proteins in Cortical Dysfunction in Schizophrenia.- Cortical Circuit Dysfunction in the NMDA Receptor Hypofunction Model for the Psychosis of Schizophrenia.- Alterations in Hippocampal Function in Schizophrenia: its Genetic Associations and Systems Implications.- Identifying Novel Target Genes in Psychotic Disorder Network Association Analyses.- Alterations in Cortical GABA Neurotransmission in Schizophrenia: Causes and Consequences.- Increased Cortical Excitability as a Critical Element in Schizophrenia Pathophysiology.
Rezensionen
From the reviews:

"Cortical Deficits in Schizophrenia: From Genes to Function is an important contribution to the literature on schizophrenic syndrome analysis. It also can serve as an excellent model of productive interdisciplinary collaboration. Clinical as well as basic scientific specialists from a very wide variety of disciplines who share a common interest in schizophrenic syndrome analysis will find much new information in this work that is insightful, original, and exceptionally well integrated." (James A. Moses, PsycCRITIQUES, Vol. 34 (3), August, 2008)