This book examines every major aspect of Alzheimer disease - clinical, epidemiologic, structural, chemical, genetic, molecular, and therapeutic. This edition includes expanded coverage of the cellular-level exploration of related dementing disorders, with in-depth presentation of prion diseases, Pick's disease, fronto-temporal disorders, transgenic models, and biochemistry of presenilins. Treatment of symptoms with therapeutic drugs is discussed, along with outcomes of and problems inherent in clinical trials for AD. The broad coverage of AD in this book benefits clinicians, educators, investigators, and health administrators. TOC:The Genetics of Alzheimer's Disease.- APP Processing, Biology and Function.- The Biology of the Presenilin Complexes.- ß-secretase: Physiological Role and Target Validation.- Cognitive Impairment in Transgenic Aß and Tau Models of Alzheimer's Disease.- Cholesterol and ß-Amyloid.- Aß Structure and Aggregation.- Signaling Mechanisms that Mediate Aß Induced Neuronal Dysfunction.- Beta Amyloid and Excitatory Synapses.- Aß Degradation.- Role of Aß transport and Clearance in the Pathogenesis and Treatment of Alzheimer's Disease.- Tau Gene Mutations in FTDP-17 Syndromes.- Animal Models of Tauopathy.- Tau and Axonal Transport.- Growth Factors in Alzheimer's Disease.
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