Stuart Warren, Paul Wyatt

Workbook for Organic Synthesis (eBook, PDF)

The Disconnection Approach

• Format: PDF

Produktbeschreibung

One approach to organic synthesis is retrosynthetic analysis. With this approach chemists start with the structures of their target molecules and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to the target molecule from simpler starting materials. This "disconnection" approach to synthesis is now a fundamental part of every organic synthesis course. Workbook for Organic Synthesis: The Disconnection Approach, 2nd Edition This workbook provides a comprehensive graded set of problems to illustrate and develop the themes of each of the chapters in the textbook Organic Synthesis: The Disconnection Approach, 2nd Edition. Each problem is followed by a fully explained solution and discussion. The examples extend the student's experience of the types of molecules being synthesised by organic chemists, and the strategies they employ to control their syntheses. By working through these examples students will develop their skills in analysing synthetic challenges, and build a toolkit of strategies for planning new syntheses. Examples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work. Reasons for wishing to synthesise each compound are given. Together the workbook and textbook provide a complete course in retrosynthetic analysis. Organic Synthesis: The Disconnection Approach, 2nd Edition There are forty chapters in Organic Synthesis: The Disconnection Approach, 2nd Edition: those on the synthesis of given types of molecules alternate with strategy chapters in which the methods just learnt are placed in a wider context. The synthesis chapters cover many ways of making each type of molecule starting with simple aromatic and aliphatic compounds with one functional group and progressing to molecules with many functional groups. The strategy chapters cover questions of selectivity, protection, stereochemistry, and develop more advanced thinking via reagents specifically designed for difficult problems. In its second edition updated examples and techniques are included and illustrated additional material has been added to take the student to the level required by the sequel, Organic Synthesis: Strategy and Control. Several chapters contain extensive new material based on courses that the authors give to chemists in the pharmaceutical industry. Workbook for Organic Synthesis: The Disconnection Approach, 2nd edition, combined with the main textbook, provides a full course in retrosynthetic analysis for chemistry and biochemistry students, and a refresher course for organic chemists working in industry and academia.

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 280
• Erscheinungstermin: 29. März 2013
• Englisch
• ISBN-13: 9781118681565
• Artikelnr.: 38401807

Autorenporträt

Dr Stuart Warren Department of Chemistry, University of Cambridge, UK Dr Warren is the author of the bestselling textbooks "Organic Synthesis: The Disconnection Approach" (Wiley), "Organic Synthesis: Strategy and Control" (Wiley) and "Organic Chemistry" (OUP) Dr Paul Wyatt School of Chemistry, University of Bristol, UK. Dr Wyatt is Director of Undergraduate Studies for the School of Chemistry at Bristol University and also Director of BRISTOL ChemLabS - a HEFCE Centre for Excellence in Teaching & Learning.?He is co-author, with Warren, of "Organic Synthesis: Strategy and Control"

Inhaltsangabe

Preface. A. Introduction: Selectivity. 1. Planning Organic Syntheses:
Tactics, Strategy and Control. 2. Chemoselectivity. 3. Regioselectivity:
Controlled Aldol Reactions. 4. Stereoselectivity: Stereoselective Aldol
Reactions. 5. Alternative Strategies for Enone Synthesis. 6. Choosing a
Strategy: The Synthesis of Cyclopentenones. B. Making Carbon-Carbon Bonds.
7. The Ortho Strategy for Aromatic Compounds. 8. -complexes of Metals. 9.
Controlling the Michael Reaction. 10. Specific Enol Equivalents. 12. Allyl
Anions. 13. Homoenolates. 14. Acyl Anion Equivalents. C. Carbon-Carbon
Double Bonds. 15. Synthesis of Double Bonds of Defined Stereochemistry. 16.
Vinyl Anions. 17. Electrophilic Attack on Alkenes. 18. Vinyl Cations. 19.
Allyl Alcohols: Allyl Cation Equivalents (and More). D. Stereochemistry.
20. Control of Stereochemistry - Introduction. 21. Diastereoselectivity.
22. Resolution. 23. The Chiral Pool: Asymmetric Synthesis with Natural
Products as Starting Materials. 24. Asymmetric Induction I: Reagent-Based
Strategy. 25. Asymmetric Induction II: Asymmetric Catalysis: Formation of
C-O and C-N Bonds. 26. Asymmetric Induction III: Asymmetric Catalysis:
Formation of C-H and C-C Bonds. 27. Asymmetric Induction IV:
Substrate-Based Strategy. 28. Kinetic Resolution. 29. Enzymes: biological
Methods in Asymmetric Synthesis. 30. New Chiral Centres from Old:
Enantiomerically Pure Compounds and Sophisticated Syntheses. 31. Strategy
of Asymmetric Synthesis. E. Functional Group Strategy. 32.
Functionalisation of Pyridine. 33. Oxidation of Aromatic Rings and of
Enol(ate)s. 34. Functionality and Pericyclic Reactions: Nitrogen
Heterocycles by Cycloadditions and Sigmatropic Rearrangements. 35.
Synthesis and Chemistry of Azoles and other Heterocycles with Two or more
Heteroatoms. 36. Tandem Organic Reactions. Index.