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Covering key areas that are particularly important for the fine chemical and pharmaceutical industries, this book highlights current challenges and encourages greater research into green organic synthesis and catalytic methodology. It uniquely unites academic and industrial contributors for a balanced treatment of current innovations from academia and case studies from industry practice. For each reaction, a description of the current state-of-art is provided, including the scope and limitations, then illustrated with examples. This offers organic and process chemists an invaluable reference…mehr

Produktbeschreibung
Covering key areas that are particularly important for the fine chemical and pharmaceutical industries, this book highlights current challenges and encourages greater research into green organic synthesis and catalytic methodology. It uniquely unites academic and industrial contributors for a balanced treatment of current innovations from academia and case studies from industry practice. For each reaction, a description of the current state-of-art is provided, including the scope and limitations, then illustrated with examples. This offers organic and process chemists an invaluable reference for applying key reactions in sustainable catalysis.
Opens the door to the sustainable production of pharmaceuticals and fine chemicals Driven by both public demand and government regulations, pharmaceutical and fine chemical manufacturers are increasingly seeking to replace stoichiometric reagents used in synthetic transformations with catalytic routes in order to develop greener, safer, and more cost-effective chemical processes. This book supports the discovery, development, and implementation of new catalytic methodologies on a process scale, opening the door to the sustainable production of pharmaceuticals and fine chemicals. Pairing contributions from leading academic and industrial researchers, Sustainable Catalysis focuses on key areas that are particularly important for the fine chemical and pharmaceutical industries, including chemo-, bio-, and organo-catalytic approaches to C-H, C-N, and C-C bond-forming reactions. Chapters include academic overviews of current innovations and industrial case studies at the process scale, providing new insights into green catalytic methodologies from proof-of-concept to their applications in the synthesis of target organic molecules. Sustainable Catalysis provides the foundation needed to develop sustainable green synthetic procedures, with coverage of such emerging topics as: * Catalytic reduction of amides avoiding LiAlH4 or B2H6 * Synthesis of chiral amines using transaminases * Industrial applications of boric acid and boronic acid catalyzed direct amidation reactions * C-H activation of heteroaromatics * Organocatalysis for asymmetric synthesis Offering a balanced perspective on current limitations, challenges, and solutions, Sustainable Catalysis is recommended for synthetic organic chemists seeking to develop new methodologies and for industrial chemists dedicated to large-scale process development.
  • Produktdetails
  • Verlag: John Wiley & Sons / WILEY
  • Seitenzahl: 421
  • Erscheinungstermin: 8. April 2013
  • Englisch
  • Abmessung: 259mm x 182mm x 27mm
  • Gewicht: 936g
  • ISBN-13: 9781118155424
  • ISBN-10: 1118155424
  • Artikelnr.: 36726893
Autorenporträt
PETER J. DUNN, PhD, is Global Green Chemistry Lead for Pfizer. Dr. Dunn has played a key role in the development of commercial processes to make several drugs, including Viagra(tm), Emselex(tm), Revatio(tm), and Sampatrilat. K. K. (MIMI) HII, PhD, holds a Readership in Catalysis in the Department of Chemistry at Imperial College London. Her research focuses on the development of sustainable catalytic processes for organic synthesis. MICHAEL J. KRISCHE, PhD, is Director of the Center for Green Chemistry and Catalysis and Robert A. Welch Chair in Science at The University of Texas at Austin. He is the recipient of the Tetrahedron Young Investigator Award, Humboldt Prize, Presidential Green Chemistry Challenge Award, and ACS Elias J. Corey Award. MICHAEL T. WILLIAMS, PhD, is an independent consultant. Previously, he was an executive director at Pfizer and played a key role in the development and commercialization of many drugs, including Zoloft(tm), Viagra(tm), and Relpax(tm).
Inhaltsangabe
Foreword vii Preface ix Contributors xi Abbreviations xiii 1 Catalytic Reduction of Amides Avoiding LiAlH4 or B2H6 1 Deborah L. Dodds and David J. Cole-Hamilton 2 Hydrogenation of Esters 37 Lionel A. Saudan 3 Synthesis of Chiral Amines Using Transaminases 63 Nicholas J. Turner and Matthew D. Truppo 4 Development of a Sitagliptin Transaminase 75 Jacob M. Janey 5 Direct Amide Formation Avoiding Poor Atom Economy Reagents 89 Benjamin M. Monks and Andrew Whiting 6 Industrial Applications of Boric Acid and Boronic Acid-Catalyzed Direct Amidation Reactions 111 Joanne E. Anderson
Jannine Cobb
Roman Davis
Peter J. Dunn
Russ N. Fitzgerald
and Alan J. Pettman 7 OH Activation for Nucleophilic Substitution 121 Jonathan M.J. Williams 8 Application of a Redox-Neutral Alcohol Amination in the Kilogram-Scale Synthesis of a GlyT1 Inhibitor 139 Martin A. Berliner 9 Olefin Metathesis: From Academic Concepts to Commercial Catalysts 163 Justyna Czaban
Christian Torborg
and Karol Grela 10 Challenge and Opportunity in Scaling-up Metathesis Reaction: Synthesis of Ciluprevir (BILN 2061) 215 Nathan Yee
Xudong Wei
and Chris Senanayake 11 C-H Activation of Heteroaromatics 233 Koji Hirano and Masahiro Miura 12 The Discovery of a New Pd/Cu Catalytic System for C-H Arylation and Its Applications in a Pharmaceutical Process 269 Jinkun Huang
Xiang Wang
and Johann Chan 13 Diarylprolinol Silyl Ethers: Development and Application as Organocatalysts 287 Hiroaki Gotoh and Yujiro Hayashi 14 Organocatalysis for Asymmetric Synthesis: From Lab to Factory 317 Feng Xu 15 Catalytic Variants of Phosphine Oxide-Mediated Organic Transformations 339 Stephen P. Marsden 16 Formation of C-C Bonds Via Catalytic Hydrogenation and Transfer Hydrogenation 363 Joseph Moran and Michael J. Krische Index 409