Dendrimers (eBook, ePUB)

Towards Catalytic, Material and Biomedical Uses
Redaktion: Caminade, Anne-Marie; Delavaux-Nicot, Beatrice; Ouali, Arnelle; Laurent, Regis; Turrin, Cedric-Olivier

• Format: ePub

Produktbeschreibung

This book will be mainly focussed on the properties and uses of dendrimers and dendrons. The aim of this book is to be the reference book about dendrimers applications. It will not describe all details, but it will give the reader a unique overview of what has currently been done with dendrimers, with numerous references and illustrations. It will be divided in four main parts: Part 1) Generalities, syntheses, characterizations and properties; Part 2) Applications in catalysis; Part 3) Applications for the elaboration or modification of materials; and Part 4) Applications in biology/medicine. The role of the nanometric size and the multiple functions of dendrimers on the properties will be emphasized.

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 456
• Erscheinungstermin: 31. August 2011
• Englisch
• ISBN-13: 9781119977575
• Artikelnr.: 37339150

Autorenporträt

Anne-Marie Caminade is Director of Research at the Centre National de la Recherche Scientifique (CNRS) in the Laboratoire de Chimie de Coordination in Toulouse (France), where she has been head of the Molecular, Macromolecular, and Supramolecular Main Group Chemistry team (15 to 20 researchers) since 2006. Having received two Ph.Ds (1984 and 1988 in Toulouse) and two Post-docs, in industry (Institut Français du Pétrole, France, 1984) and as an Alexander von Humboldt Fellow at the University of Saarbrücken (Germany, 1988), she has been working since 1985 at the CNRS in Toulouse. Her current research interest is on the synthesis, reactivity and study of properties and applications of dendrimers and dendritic macromolecules in three main fields: Catalysis, Biology-Medicine, and Materials. She is the co-author of 278 publications and 25 patents. She is the coordinator or "scientist in charge" of several French and European projects, and received the bronze medal of the CNRS in 1989, and the Organic Chemistry Prize of the French Chemical Society in 2006. Co-authors for the book will be members of her research team including: Dr Cédric-Olivier Turrin (biology), Dr Régis Laurent and Dr Armelle Ouali (catalysis), Dr Béatrice Delavaux-Nicot (materials).

Inhaltsangabe

Preface xv Part 1 Generalities, Syntheses, Characterizations, and
Physicochemical Properties 1 1 Syntheses of Dendrimers and Dendrons 3
Anne-Marie Caminade 1.1 Introduction: What Are Dendrimers and Dendrons? 3
1.2 Syntheses of Poly(propyleneimine) Dendrimers (PPI) 5 1.3 Synthesis of
Poly(amidoamine) Dendrimers (PAMAM) 5 1.4 Syntheses of Poly(ether)
Dendrimers 7 1.5 Syntheses of Poly(ester) Dendrimers 10 1.6 Synthesis of
Poly(lysine) Dendrimers 14 1.7 Syntheses of Silicon-Containing Dendrimers
15 1.8 Syntheses of Phosphorus-Containing Dendrimers 16 1.9 Syntheses of
Carbon-Based Dendrimers 17 1.10 Syntheses of Dendrimers Constituted of
Nitrogen Heterocycles 19 1.11 Syntheses by Self-Assembly 21 1.12
Accelerated Syntheses 26 1.13 Conclusion 30 References 30 2 Methods of
Characterization of Dendrimers 35 Anne-Marie Caminade 2.1 Introduction 35
2.2 Spectroscopy and Spectrometry 36 2.3 Scattering Techniques 47
Wide-Angle X-ray Scattering (WAXS) 48 2.4 Microscopy 48 2.5 Rheology and
Physical Characterizations 50 2.6 Separation Techniques 52 2.7 Conclusion
53 References 54 3 Luminescent Dendrimers 67 Anne-Marie Caminade 3.1
Introduction 67 3.2 Dendrimers with Fluorescent Terminal Groups 68 3.3
Luminescent Group at the Core of Dendrimers and Energy/Light-Harvesting
Properties 74 3.4 Fluorescent Groups inside the Structure of Dendrimers 79
3.5 Intrinsically Fluorescent Dendrimers 81 3.6 Two-Photon-Excited
Fluorescence of Dendrimers 86 3.7 Conclusion 89 References 90 4
Stimuli-Responsive Dendrimers 99 Anne-Marie Caminade 4.1 Introduction 99
4.2 Photoresponsive Dendrimeric Structures 100 4.3 Thermoresponsive
Dendrimeric Structures 110 4.4 Dendrimers Responsive to Solution Media
Changes 114 4.5 Conclusion 117 References 118 5 Liquid Crystalline
Dendrimers 125 Anne-Marie Caminade 5.1 Introduction 125 5.2 Mesogenic
Groups as Terminal Functions of Dendrons 126 5.3 Mesogenic Groups as
Terminal Functions of Dendrimers 131 5.4 Mesogenic Groups as Branches of
Dendrimers 134 5.5 Conclusion 135 References 136 6 Dendrimers and
Nanoparticles 141 Cédric-Olivier Turrin and Anne-Marie Caminade 6.1
Introduction 141 6.2 Dendrimers or Dendrons for Coating Nanoparticles 142
6.3 Dendrimers as Templates for the Synthesis of Dendrimer-Encapsulated
Nanoparticles (DENs) 152 6.4 Conclusion and Perspectives 154 References 155
Part 2 Applications in Catalysis 163 7 Terminal Groups of Dendrimers as
Catalysts for Homogeneous Catalysis 165 Armelle Ouali and Anne-Marie
Caminade 7.1 General Introduction 165 7.2 Catalytic Organometallic Sites as
Catalysts for Homogeneous Catalysis 167 7.3 Organocatalysis with Dendrimers
178 7.4 Conclusion 178 References 179 8 Catalytic Sites inside the
Dendrimeric Structure for Homogeneous Catalysis 183 Armelle Ouali and
Anne-Marie Caminade 8.1 Introduction 183 8.2 Catalytic Sites as the Core of
Dendrimers 184 8.3 Catalytic Sites inside the Branches of Dendrimers 191
8.4 Conclusion 192 References 193 9 Dendrimers as Homogeneous
Enantioselective Catalysts 197 Armelle Ouali and Anne-Marie Caminade 9.1
Introduction 197 9.2 Catalytic Organometallic Sites as Catalysts for
Homogeneous Catalysis 198 9.3 Organocatalysis with Dendrimers 209 9.4
Conclusion 210 References 210 10 Catalysis with Dendrimers in Particular
Media 215 Régis Laurent and Anne-Marie Caminade 10.1 Introduction 215 10.2
Two-Phase (Liquid-Liquid) Media 216 10.3 Catalysis in Ionic Liquids 219
10.4 Catalysis in Supercritical Media 220 10.5 Catalysis in Aqueous Media
221 10.6 Conclusion 234 References 234 11 Heterogeneous Catalysis with
Dendrimers 239 Régis Laurent and Anne-Marie Caminade 11.1 Introduction 239
11.2 Catalysis with Dendrons Synthesized from a Solid Material 240 11.3
Catalysis with Dendrons or Dendrimers Grafted on to a Solid Surface 254
11.4 Catalysis with Insoluble Dendrimers 257 11.5 Conclusion 260 References
261 Part 3 Applications for the Elaboration or Modification of Materials
267 12 Dendrimers inside Materials 269 Régis Laurent and Anne-Marie
Caminade 12.1 Introduction 269 12.2 Dendrimers for the Elaboration of Gels
270 12.3 Dendrimers inside Silica Gels 280 12.4 Dendrimers inside Other
Types of Materials 285 12.5 Dendrimers for the Elaboration of OLEDs 288
12.6 Conclusion 298 References 299 13 Self-Assembly of Dendrimers in Layers
313 Béatrice Delavaux-Nicot and Anne-Marie Caminade 13.1 Introduction 313
13.2 Langmuir-Blodgett Films of Dendrons and Dendrimers 314 13.3 Assemblies
of Dendrons and Dendrimers on Solid Surfaces 326 13.4 Several Routes for
the Formation of Dendron or Dendrimer Multilayers 334 13.5 Nanoimprinting
with Dendrons and Dendrimers on Solid Surfaces 342 13.6 Conclusion 350
References 351 14 Dendrimers as Chemical Sensors 361 Anne-Marie Caminade
14.1 Introduction 361 14.2 Dendrimers as Chemical Sensors in Solution 362
14.3 Dendrimers as Electrochemical Sensors 365 14.4 Dendrimers on Modifi ed
Surfaces as Chemical Sensors 367 14.5 Conclusion 370 References 370 15
Dendrimers as Biological Sensors 375 Anne-Marie Caminade 15.1 Introduction
375 15.2 Dendrimers as Sensors in Solutions of Biological Media 375 15.3
Detection by Electrochemical Methods 378 15.4 Dendrimers or Dendrons for
DNA Microarrays 380 15.5 Dendrimers for Other Types of Biomicroarrays 383
15.6 Dendrimers on Other Types of Support 384 15.7 Dendrimers as Multiply
Labeled Entities Connected to the Target 385 15.8 Conclusion 386 References
387 Part 4 Applications in Biology/Medicine 393 16 Dendrimers for Imaging
395 Cédric-Olivier Turrin and Anne-Marie Caminade 16.1 Introduction 395
16.2 Magnetic Resonance Imaging with Dendrimers 395 16.3 Other Types of
Imaging with Dendrimers 403 16.4 Conclusion and Perspectives 407 References
407 17 Dendrimers as Transfection Agents 413 Cédric-Olivier Turrin and
Anne-Marie Caminade 17.1 Introduction 413 17.2 Gene Transfection with PAMAM
Dendrimers 415 17.3 Gene Transfection with Other Dendrimers 421 17.4
Conclusion and Perspective 426 References 426 18 Dendrimer Conjugates for
Drug Delivery 437 Cédric-Olivier Turrin and Anne-Marie Caminade 18.1
Introduction 437 18.2 Improving Bioavailability with Dendrimers 438 18.3
Passive Targeting in Tumors with Dendrimer-Drug Conjugates 440 18.4 Active
Targeting with Site-Specifi c Dendrimer-Drug Conjugates 446 18.5 Dendrimers
for Photodynamic Therapy (PDT) 449 18.6 Dendrimers for Boron Neutron
Capture Therapy (BNCT) 451 18.7 Conclusion and Perspectives 452 References
453 19 Encapsulation of Drugs inside Dendrimers 463 Cédric-Olivier Turrin
and Anne-Marie Caminade 19.1 Introduction 463 19.2 From Dendritic Boxes to
Dendrimer-Based Formulations 464 19.3 Improving Bioavailability with
Dendrimers? 464 19.4 Toxicological Issues 465 19.5 Dendrimer-Based
Formulations for Drug Delivery 466 19.6 Conclusion and Perspectives 477
References 477 20 Unexpected Biological Applications of Dendrimers and
Specifi c Multivalency Activities 485 Cédric-Olivier Turrin and Anne-Marie
Caminade 20.1 Introduction 485 20.2 Dendrimers and Multivalency 486 20.3
Antimicrobial Dendrimers 488 20.4 From Immunomodulation to Regenerative
Medicine 494 20.5 Conclusion and Perspectives 501 References 502 21 General
Conclusions and Perspectives 511 Anne-Marie Caminade Index 515