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Much research has attempted to show direct linear relations betweengenes and disorder. However, scientists have been discouraged byinconsistent findings based on this simple gene-phenotype approach.The alternative approach is to incorporate information about theenvironment. A gene-environment interaction approach assumes thatenvironmental pathogens cause disorder, whereas genes influencesusceptibility to environmental pathogens. This book brings together contributions from experts frommultiple disciplines who discuss: * How epidemiological cohort studies can better integratephysiological…mehr

Produktbeschreibung
Much research has attempted to show direct linear relations betweengenes and disorder. However, scientists have been discouraged byinconsistent findings based on this simple gene-phenotype approach.The alternative approach is to incorporate information about theenvironment. A gene-environment interaction approach assumes thatenvironmental pathogens cause disorder, whereas genes influencesusceptibility to environmental pathogens. This book brings together contributions from experts frommultiple disciplines who discuss: * How epidemiological cohort studies can better integratephysiological (mechanistic) measures; * How best to characterise subjects' vulnerability versusresilience by moving beyond single genetic polymorphisms; * How gene hunters can benefit from recruiting samples selectedfor known exposures; * How environmental pathogens can be used as tools for genehunting; * How to deal with potential spurious (statistical) interactions,and * How genes can help explain fundamental demographic propertiesof disorders (e.g. sex distribution, age effects).

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  • Produktdetails
  • Verlag: John Wiley & Sons
  • Seitenzahl: 232
  • Erscheinungstermin: 15. September 2008
  • Englisch
  • ISBN-13: 9780470696798
  • Artikelnr.: 37298891
Autorenporträt
Michael Rutter is Professor of Developmental Psychopathology at the Institute of Psychiatry, Kings College London. His research has included the genetics of autism, the effect of early severe deprivation on Romanian orphans adopted into Britain, and the study of both school and environmental influences on childrens behavior. He has published nearly 40 books.