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- Verlag: John Wiley & Sons
- Seitenzahl: 216
- Erscheinungstermin: 20. Oktober 2010
- ISBN-13: 9780470973073
- Artikelnr.: 37301146
collection, characterization and storage. Sources of biological evidence. Collection and handling of material at the crime scene. Identification and characterization of biological evidence. Evidence collection. Sexual and physical assault. Storage of biological material. 4 DNA extraction and quantification. DNAextraction. General principles of DNA extraction. DNA extraction from challenging samples. Quantification of DNA. DNA IQ system. 5 Polymerase chain reaction. The evolution of PCR
based profiling in forensic genetics. DNA replication: the basis of the PCR. The components of PCR. Taq DNA polymerase. The PCR process. PCR inhibition. Sensitivity and contamination. The PCR laboratory. 6 The analysis of short tandem repeats. Structure of STR loci. The development of STR multiplexes. Detection of STR polymorphisms. Interpretation of STR profiles. 7 Assessment of STR profiles. Stutter peaks. Split peaks (±N). Pull
up. Template DNA Overloaded profiles. Low template DNA typing. Peak balance. Mixtures. Degraded DNA. PCR inhibition. 8 Statistical interpretation of STR profiles. Population genetics. Deviation from the Hardy
Weinberg equilibrium. Statistical tests to determine deviation from the Hardy
Weinberg equilibrium. Estimating the frequencies of STR profiles. Corrections to allele frequency databases. Which population frequency database should be used? Conclusions. 9 Evaluation and presentation of DNA evidence. Hierarchies of propositions. Likelihood ratios. Two fallacies. Comparison of three approaches. 10 Databases of DNA profiles. The UK National DNA Database. Legislation in England and Wales. International situation. 11 Kinship testing. Parentage testing. Punnett square. Identification of human remains. 12 Single nucleotide polymorphisms. SNPs
occurrence and structure. Detection of SNPs. SNP detection for forensic applications. Forensic applications of SNPs. SNPs compared with STR loci. 13 Lineage markers. Mitochondria. Applications of mtDNA profiling. Haplotypes and haplogroups. The Y chromosome. Forensic applications of Y chromosome polymorphisms. 14 Non
human DNA typing. Non
human sample types. Species identification. Linkage to an individual using STR Loci. Linkage to an individual using mitochondrial loci. Microbial DNA testing. Concluding comments. Appendix A: Forensic parameters. Appendix B: Useful web links. Glossary. Abbreviations. Index.
Preface to first edition
1. Introduction to forensic genetics
2. DNA structure and the genome.
3. Biological material - collection, characterization and storage.
4. DNA extraction and quantification.
5. Polymerase chain reaction.
6. The analysis of short tandem repeats.
7. Assessment of STR profiles.
8. Statistical interpretation of STR profiles.
9. Evaluation and presentation of DNA evidence.
10. Databases of DNA profiles.
11. Kinship testing.
12. Single nucleotide polymorphisms.
13. Lineage markers.
14. Non-human DNA typing.
Appendix A. Forensic parameters.
Appendix B. Useful web links.