Voltage Gated Calcium Channels is the first comprehensive book in the calcium channel field, encompassing over thirty years of progress towards our understanding of calcium channel structure, function, regulation, physiology, pharmacology, and genetics. This book balances contributions from many of the leading authorities in the calcium channel field with fresh perspectives from risings stars in the area, taking into account the most recent literature and concepts. This is the only all-encompassing calcium channel book currently available, and is an essential resource for academic researchers at all levels in the areas neuroscience, biophysics, and cardiovascular sciences, as well as to researchers in the drug discovery area. TOC:Role and sources of intracellular calcium.- Techniques to study changes in cellullar calcium.- History of calcium channels, subtypes of native calcium channels.- Biochemical characterization of calcium channels.- Structure, subunit composition and splicing of calcium channels.- Role of the beta subunit in calcium channel function.- Calcium channel targeting and distribution.- Calcium channels and the exocytotic machinery.- G protein regulation of calcium channels.- Regulation of calcium channels by protein phosphorylation.- Calcium sensitive inactivation.- Voltage dependent inactivation of calcium channels.- Permeation and divalent cation block of voltage gated calcium channels.- The rundown phenomenon.- Calcium channels as therapeutic targets.- Calcium channelopathies.- Drug interaction sites on voltage gated calcium channels.- Role of the inactivated state in calcium channel block.- Block of calcium channels by toxin peptides.- Role of calcium channels in the heart.- Role of T-type calcium channels in neuronal physiology.- Role of calcium channels in visual transduction?- Calcium channel knockouts.
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