Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks (eBook, PDF)
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This book is authored by an exciting mixture of top experts and young rising stars from the fields of molecular chaperones and stress adaptation. In addition to giving a comprehensive summary with original references to their field, all authors share their hypotheses and vision on future trends with the reader. The book makes a novel synthesis of the molecular aspects of the stress response and long term adaptation processes with the system biology approach of biological networks. A novel perspective of "old facts" is provided in each chapter, where "old" means only 5-10 years in this rapidly…mehr

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Produktbeschreibung
This book is authored by an exciting mixture of top experts and young rising stars from the fields of molecular chaperones and stress adaptation. In addition to giving a comprehensive summary with original references to their field, all authors share their hypotheses and vision on future trends with the reader. The book makes a novel synthesis of the molecular aspects of the stress response and long term adaptation processes with the system biology approach of biological networks. A novel perspective of "old facts" is provided in each chapter, where "old" means only 5-10 years in this rapidly expanding field. The integrative, holistic nature of the book makes it an excellent reading for undergraduates, graduate students and fellow scientists extending their knowledge and studies. TOC:Protein Misassembly: Macromolecular Crowding and Molecular Chaperones.- The Cellular "Networking" of Mammalian HSP27 And Its Functions in the Control of Protein Folding, Redox State and Apoptosis.- Molecular Interaction Network of the HSP90 Chaperone System.- Organization of the Functions and Components of the Endoplasmic Reticulum.- Molecular Crime and Cellular Punishment: Active Detoxification of Misfolded and Aggregated Proteins in the Cell by the Chaperone and Protease Networks.- Chaperones as Parts of Cellular Networks.- Chaperones as Parts of Organelle Networks.- Heat Shock Factor 1 as A Coordinator of Stress and Developmental Pathways.- Chaperone Regulation of the Heat Shock Protein Response.- Mechanisms of Activation and Regulation of the Heat Shock-Sensitive Signaling Pathways.- Membrane-Regulated Stress Response: A Theoretical and Practical Approach.- Beyond the Lipid Hypothesis: Mechanisms Underlying Phenotypic Plasticity in Inducible Cold Tolerance.- Trehalose as A "Chemical Chaperone": Fact and Fantasy.- Chaperones as Part of Immune Networks.- The Stress of Misfolded Proteins: C. Elegans Models for Neurodegenerative Disease and Aging.- HSP90 and Developmental Networks.- Index.

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  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Erscheinungstermin: 09.08.2007
  • Englisch
  • ISBN-13: 9780387399751
  • Artikelnr.: 37287408
Autorenporträt
Peter Csermely, Semmelweis University, Budapest, Hungary / Laszlo Vigh, Szeged Biological Research Center, Szeged, Hungary
Inhaltsangabe
Protein Misassembly.
The Cellular "Networking" of Mammalian Hsp27 and Its Functions in the Control of Protein Folding, Redox State and Apoptosis.
Molecular Interaction Network of the Hsp90 Chaperone System.
Organization of the Functions and Components of the Endoplasmic Reticulum.
Molecular Crime and Cellular Punishment.
Chaperones as Parts of Cellular Networks.
Chaperones as Parts of Organelle Networks.
Heat Shock Factor 1 as a Coordinator of Stress and Developmental Pathways.
Chaperone Regulation of the Heat Shock Protein Response.
Mechanisms of Activation and Regulation of the Heat Shock
Sensitive Signaling Pathways.
Membrane
Regulated Stress Response.
Beyond the Lipid Hypothesis.
Trehalose As a "Chemical Chaperone".
Chaperones As Part of Immune Networks.
The Stress of Misfolded Proteins.
Hsp90 and Developmental Networks.