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Introduction.- Biomechanics of Joint Synovia.- Brief Review of Liquid Crystals.- Modern Concepts of Friction and Lubrication of Solids.- Modern Concepts of Friction, Wear and Lubrication of Joints.- Effect of Liquid Crystals on Biological Mechanisms of Reducing Joint Friction.- Liquid Crystals as Effective Preparations for Treatment of Joint and Similar Pathologies.- Conclusions.