Advances in Enzymology and Related Areas of Molecular Biology, Volume 78 (eBook, PDF)

Redaktion: Toone, Eric J.

• Format: PDF

Produktbeschreibung

This book covers important advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. Advances in Enzymology focuses on enzymes, the primary catalysts of life processes. The explanation of the behavior of enzymes can be found via studies of their chemical mechanisms and can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. The transglutaminases, first described in 1957, are a large, widely-distributed family of enzymes canonically responsible for the amidation/transamidation of protein side chains. The extraordinary diversity of names associated with various enzymatic activities now recognized and aggregated as transglutaminase bears witness to the remarkable diversity of biological roles associated with the activity, including myriad human diseases.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 560
• Erscheinungstermin: 13. Oktober 2011
• Englisch
• ISBN-13: 9781118105801
• Artikelnr.: 37348653

Autorenporträt

Eric J. Toone, PhD, is Professor of Chemistry and Professor of Biochemistry at Duke University. He holds numerous patents and has written extensively on physical organic and biophysical chemistry. Professor Toone has served as a member of the Bioorganic and Natural Products Study Section at the National Institutes of Health, and is currently a member of the NSERC Organic & Inorganic Review panel (Canada). Professor Toone is the Deputy Director for the Advanced Research Projects Agency--Energy (ARPA-E) of the Department of Energy and directs ARPA-E's electrofuels program.

Inhaltsangabe

Contributors vii Preface ix Structure and Regulation of Type 2 Transglutaminase in Relation to Its Physiological Functions and Pathological Roles 1 Carlo M. Bergamini
Russell J. Collighan
Zhuo Wang
and Martin Griffin Physiopathological Roles of Human Transglutaminase 2 47 Vittorio Gentile Transglutaminase in Epidermis and Neurological Disease or What Makes a Good Cross-Linking Substrate 97 Guylaine Hoffner
Amandine VanHoutteghem
William Andre
and Philippe Djian Transglutaminase 2: A New Paradigm for NF-B Involvement in Disease 161 Soo-Youl Kim Transglutaminase 2 At the Crossroads between Cell Death and Survival 197 Mauro Piacentini
Manuela D'Eletto
Laura Falasca
Maria Grazia Farrace
and Carlo Rodolfo Tissue Transglutaminase and Its Role in Human Cancer Progression 247 Bo Li
Richard A. Cerione
and Marc Antonyak Transglutaminase 2 Dysfunctions in the Development of Autoimmune Disorders: Celiac Disease and TG2-/-Mouse 295 Zsuzsa Szondy
Ilma Korponay-Szabo
Robert Kiraly
and Laszlo Fesus Effects and Analysis of Transglutamination on Protein Aggregation and Clearance in Neurodegenerative Diseases 347 Zoltan Nemes Transglutaminase-Mediated Remodeling of the Human Erythrocyte Membrane Skeleton: Relevance for Erythrocyte Diseases with Shortened Cell Lifespan 385 Laszlo Lorand
S. N. Prasanna Murthy
Anwar A. Khan
Weihua XUE
Oksana Lockridge
and Athar H. Chishti Irreversible Inhibitors of Tissue Transglutaminase 415 Jeffrey W. Keillor
Nicolas Chabot
Isabelle Roy
Amina Mulani
Olivier Leogane
and Christophe Pardin Methionine Adenosyltransferase (S-Adenosylmethionine Synthetase) 449 Mar1a A. Pajares and George D. Markham Index 523