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Sliding Filament Mechanism in Muscle Contraction: Fifty Years of Research covers the history of the sliding filament mechanism in muscle contraction from its discovery in 1954 by H.E. Huxley through and including modern day research. Chapters include topics in dynamic X-ray diffraction, electron microscopy, muscle mechanisms, in-vitro motility assay, cardiac versus smooth muscle, motile systems, and much more. TOC:From the contents: Preface.- Early Development in Muscle Research and the Role of New Structureal Technologies.- The Molecular Basis of Cross-Bridge Function.- Molecular…mehr

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Produktbeschreibung
Sliding Filament Mechanism in Muscle Contraction: Fifty Years of Research covers the history of the sliding filament mechanism in muscle contraction from its discovery in 1954 by H.E. Huxley through and including modern day research. Chapters include topics in dynamic X-ray diffraction, electron microscopy, muscle mechanisms, in-vitro motility assay, cardiac versus smooth muscle, motile systems, and much more. TOC:From the contents: Preface.- Early Development in Muscle Research and the Role of New Structureal Technologies.- The Molecular Basis of Cross-Bridge Function.- Molecular Synchronization in Actomyosin Motors from Single Molecule to Muscle Fiber via Nanomuscle.- Distribution of Crossbridge States in Contracting Muscle.- X-Ray Diffraction Studies of Striated Muscles.- Conformational Change and Regulation of Myosin Molecules.- Driving Filament Sliding: Weak Binding Cross-bridge states, Strong Binding Cross-bridge States, and the Power Stroke.- Mysteries about Amplitude and Efficiency of Cross-bridge Powerstroke.- Sarcomere Dynanmics, Stepwise Shortening, and the Nature of Contraction.- Cross-bridge Formation Detected by Stiffness Measurements in Single Muscle Fibers.- Non Cross-bridge Stiffness in Skeletal Muscle Fibers at Rest and During Activity.- Nature's Strategy for Optimizing Power Generation in Insect Flight Muscle.- From Crossbridges to Metabolism: System Biology for Energetics.- Energetics, Mechanics, and Molecular Engineering of Calcium Cycling in Skeletal Muscle.- Heat, Phosphorus NMR, and Microcalorimetry in Relation to the Mechanism of Filament Sliding.

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  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Erscheinungstermin: 27.04.2007
  • Englisch
  • ISBN-13: 9780387249902
  • Artikelnr.: 37286361
Autorenporträt
Haruo Sugi, Teiko University, Tokyo, Japan
Inhaltsangabe
Preface
Early Development in Muscle Research and the Role of New Structureal Technologies
The Molecular Basis of Cross
Bridge Function
Molecular Synchronization in Actomyosin Motors from Single Molecule to Muscle Fiber via Nanomuscle
Distribution of Crossbridge States in Contracting Muscle
X
Ray Diffraction Studies of Striated Muscles
Conformational Change and Regulation of Myosin Molecules
Driving Filament Sliding: Weak Binding Cross
bridge states, Strong Binding Cross
bridge States, and the Power Stroke
Mysteries about Amplitude and Efficiency of Cross
bridge Powerstroke
Sarcomere Dynanmics, Stepwise Shortening, and the Nature of Contraction
Cross
bridge Formation Detected by Stiffness Measurements in Single Muscle Fibers
Non Cross
bridge Stiffness in Skeletal Muscle Fibers at Rest and During Activity
Nature's Strategy for Optimizing Power Generation in Insect Flight Muscle
From Crossbridges to Metabolism: System Biology for Energetics
Energetics, Mechanics, and Molecular Engineering of Calcium Cycling in Skeletal Muscle
Heat, Phosphorus NMR, and Microcalorimetry in Relation to the Mechanism of Filament Sliding
How Two
Foot Molecular Motors May Walk
Molecular Basis of Calcium Regulation of Striated Muscle Contraction
Mechanisms of Calcium Release from the Sarcoplasmic Reticulum in Skeletal Muscle
From Inward Spread of Activation, Active Elongation to the Effect of Organic Calcium Channel Blockers in Muscle Excitation
Contraction Coupling
Cardiac Myosin Binding Protein C: Modulator of Contractility
Human Atrial Myosin Light Chain 1 Expression Accentuates Heart Failure
Cytoplasmic Free Concentrations of Ca2+ in Skeletal Muscle Cells
Mysterious Beauty of Beating Heart: Cardiac Mechano
Energetico Informatics
Is Myosin Phosphorylation Sufficient to Regulate Smooth Muscle Contraction?
Comparative Aspects of Crossbridge Function: Skinned Fibre Studies
Dynamic Structures of Myosin,Kinesin, and Troponin as Detected by SDSL
ESR
Mutations of Transcription Factors in Human with Heart Disease for Understanding the Development and Mechanisms of Congenital Cardiovascular Heart Disease
General Discussion Part I: Skeletal Muscle Mechanics
General Discussion Part II: Skeletal Muscle Energetics
General Discussion Part III: Skeletal Muscle Ultrastructure
General Discussion Part IV: Cardiac Muscle
General Discussion Part V: Smooth Muscle
Concluding Remarks
Participant Photos
Participants
Index