Roberta Masella, Giuseppe Mazza

Glutathione and Sulfur Amino Acids in Human Health and Disease (eBook, PDF)

• Format: PDF

Produktbeschreibung

The complex roles of glutathione and sulfur amino acids in human health Glutathione (gamma-L-glutamyl-L-cysteinylglycine, GSH) is a major antioxidant acting as a free radical scavenger that protects the cell from reactive oxygen species (ROS). Sulfur amino acids (SAAs), such as methionine and cysteine, play a critical role in the maintenance of health. GSH depletion as well as alterations of SAA metabolism are linked to a host of disease states including liver cirrhosis, various pulmonary diseases, myocardial ischemia and reperfusion injury, aging, Parkinson's disease, Alzheimer's disease, sepsis, and others. This book provides researchers with a comprehensive review of the biochemistry, absorption, metabolism, biological activities, disease prevention, and health promotion of glutathione and sulfur amino acids. The twenty-two chapters explore such topics as: * Chemistry, absorption, transport, and metabolism of GSH and sulfur amino acids * Antioxidant and detoxification properties of GSH and sulfur amino acids, highlighting the enzymatic systems involved in antioxidant defenses * Biological activities of GSH and sulfur amino acids and their role in modulating cell processes * Role of GSH and sulfur amino acid deficiency and alteration in the onset of diseases and in aging * Protective effects exerted by GSH and sulfur amino acids when used as drugs, functional foods, and nutraceuticals in humans and animals Special attention is paid to the molecular mechanisms for the modulation of transcription factors and enzyme activities, as well as the nutritional and therapeutic significance of dietary sulfur amino acids as shown in human and animal models. With more than 2,000 scientific references, this book provides food scientists, nutritionists, biochemists, food technologists, chemists, molecular biologists, and public health professionals with a comprehensive and up-to-date examination of glutathione and sulfur amino acids in human health and disease.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 620
• Erscheinungstermin: 7. August 2009
• Englisch
• ISBN-13: 9780470475966
• Artikelnr.: 37292721

Autorenporträt

Roberta Masella works as Head of the Human Nutrition Unit, Department of Veterinary Public Health and Food Safety, at Istituto Superiore di Sanità (ISS). She was previously head of the Gastroenterology Unit in the Laboratory of Metabolism and Pathological Biochemistry at ISS. She is the author of nearly 100 peer-reviewed publications, as well as seventy presentations at international congresses. Giuseppe (Joe) Mazza is the Principal Food and Bioscience Research Scientist at Agriculture and Agri-Food Canada, Summerland, British Columbia, and an adjunct professor in food science and nutrition at the Universities of Manitoba and British Columbia. A prolific author and editor of over 200 journal articles and twelve books, he is on the editorial boards of World of Food Science, Plant Foods for Human Nutrition, Italian Journal of Food Science, and Journal of Functional Foods.

Inhaltsangabe

PREFACE. CONTRIBUTORS. I INTRODUCTION. 1 GLUTATHIONE AND THE
SULFUR-CONTAINING AMINO ACIDS: AN OVERVIEW (John T. Brosnan and Margaret E.
Brosnan). Acknowledgments. References. II CHEMISTRY AND METABOLISM OF GSH
AND SULFUR AMINO ACIDS. 2 SULFUR AMINO ACIDS CONTENTS OF DIETARY PROTEINS:
DAILY INTAKE AND REQUIREMENTS (Cécile Bos, Jean-François Huneau, and Claire
Gaudichon). References. 3 CELLULAR COMPARTMENTALIZATION OF GLUTATHIONE
(Federico V. Pallardó, Jelena Markovic, and José Vinã). References. 4
INTESTINAL METABOLISM OF SULFUR AMINO ACIDS (Nancy Benight, Douglas G.
Burrin, and Barbara Stoll). References. 5 HEPATIC SULFUR AMINO ACID
METABOLISM (Kevin L. Schalinske). References. III ANTIOXIDANT AND
DETOXIFICATION ACTIVITIES. 6 GLUTATHIONE AND SULFUR CONTAINING AMINO ACIDS:
ANTIOXIDANTAND CONJUGATION ACTIVITIES (Nils-Erik Huseby, Elisabeth
Sundkvist, and Gunbjørg Svineng). References. 7 GLUTAREDOXIN AND
THIOREDOXIN ENZYME SYSTEMS: CATALYTIC MECHANISMS AND PHYSIOLOGICAL
FUNCTIONS (Elizabeth A. Sabens and John J. Mieyal). References. 8
METHIONINE SULFOXIDE REDUCTASES: A PROTECTIVE SYSTEM AGAINST OXIDATIVE
DAMAGE (Herbert Weissbach and Nathan Brot). Acknowledgment. References. IV
BIOACTIVITY OF GSH AND SULFUR AMINO ACIDS AS REGULATORS OF CELLULAR
PROCESSES. 9 REGULATION OF PROTEIN FUNCTION BY GLUTATHIONYLATION (Pietro
Ghezzi and Paolo Di Simplicio). References. 10 GSH, SULFUR AMINO ACIDS, AND
APOPTOSIS (Giuseppe Filomeni, Katia Aquilano, and Maria Rosa Ciriolo).
Acknowledgments. References. 11 METHIONINE OXIDATION: IMPLICATION IN
PROTEIN REGULATION, AGING, AND AGING-ASSOCIATED DISEASES (Jackob Moskovitz
and Derek B. Oien). References. 12 SULFUR AMINO ACIDS, GLUTATHIONE, AND
IMMUNE FUNCTION (Robert Grimble). References. V GSH AND SULFUR AMINO ACIDS
IN PATHOLOGICAL PROCESSES. 13 SULFUR AMINO ACID DEFICIENCY AND TOXICITY:
RESEARCH WITH ANIMAL MODELS (David H. Baker and Ryan N. Dilger).
References. 14 HUMAN PATHOLOGIES AND ABERRANT SULFUR METABOLISM (Danyelle
M. Townsend, Haim Tapiero, and Kenneth D. Tew). References. 15 INBORN
ERRORS OF GSH METABOLISM (llinor Ristoff). Acknowledgments. References. 16
HOMOCYSTEINE METABOLISM AND PATHOLOGICAL IMPLICATIONS: THE HOMOCYSTEINE
THIOLACTONE HYPOTHESIS OF VASCULAR DISEASE (Hieronim Jakubowski).
References. 17 HOMOCYSTEINE AND CARDIOVASCULAR DISEASE (Jayanta R. Das and
Sanjay Kaul). References. 18 HOMOCYSTEINE AND NEUROLOGICAL DISORDERS
(Rodica E. Petrea and Sudha Seshadri). References. 19 GLUTATHIONE, SULFUR
AMINO ACIDS, AND CANCER (José M. Estrela, Julian Carretero, and Angel
Ortega). References. VI GSH AND SULFUR AMINO ACIDS AS DRUGS AND
NUTRACEUTICALS. 20 GSH, GSH DERIVATIVES, AND ANTIVIRAL ACTIVITY (Anna
Teresa Palamara, Lucia Nencioni, Rossella Sgarbanti, and Enrico Garaci).
References. 21 N-ACETYL CYSTEINE AND CYTOPROTECTIVE EFFECTS AGAINST
BRONCHOPULMONARY DAMAGE: FROM IN VITRO STUDIES TO CLINICAL APPLICATION
(Richard Dekhuijzen). References. 22 TAURINE AS DRUG AND FUNCTIONAL FOOD
COMPONENT (Ramesh C. Gupta, Massimo D'Archivio, and Roberta Masella).
References. SUBJECT INDEX.