Alejandro Cifuentes

Foodomics

Advanced Mass Spectrometry in Modern Food Science and Nutrition
Herausgeber: Cifuentes, Alejandro

• Gebundenes Buch

Produktbeschreibung

This book introduces the principles of foodomics through the review of advanced Mass Spectrometry (MS) technologies applied to this new discipline. The coverage details specific "omics" approaches based on MS technologies that have been (or can be) applied in foodomics, providing a picture of the most innovative applications and future trends. It explains the fundamental branches of foodomics such as metabolomics, proteomics, and systems biology. And it provides a global perspective on "omics" approaches based on MS techniques combined with systems biology in food science and nutrition, a topic not covered so far.

Produktdetails

• Wiley-Interscience Series on Mass Spectrometry .
• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 580
• Erscheinungstermin: 18. März 2013
• Englisch
• Abmessung: 241mm x 161mm x 38mm
• Gewicht: 955g
• ISBN-13: 9781118169452
• ISBN-10: 111816945X
• Artikelnr.: 36633599

Autorenporträt

ALEJANDRO CIFUENTES, PhD, is Full Research Professor at the National Research Council (CSIC) in Madrid, Spain. He has authored more than 200 SCI papers and is Editor of two journals: TrAC Trends in Analytical Chemistry and Electrophoresis. Dr. Cifuentes was the first to define the new discipline of foodomics in an SCI journal. His research centers on the development of advanced analytical methods for foodomics, food quality and safety, as well as the isolation and identification of biologically active natural products.

Inhaltsangabe

Preface xiii Contributors xv 1 Foodomics: Principles and Applications 1
Alejandro Cifuentes 1.1 Introduction to Foodomics 1 1.2 Foodomics
Applications: Challenges, Advantages, and Drawbacks 6 1.3 Foodomics,
Systems Biology, and Future Trends 11 Acknowledgments 12 References 12 2
Next Generation Instruments and Methods for Proteomics 15 Mar?a del Carmen
Mena and Juan Pablo Albar 2.1 Introduction 15 2.2 Emerging Methods in
Proteomics 19 2.3 The Move from Shotgun to Targeted Proteomics Approaches
34 2.4 New Instrumental Methods for Proteomics 40 2.5 Bioinformatics Tools
49 References 55 3 Proteomic-Based Techniques for the Characterization of
Food Allergens 69 Gianluca Picariello, Gianfranco Mamone, Francesco Addeo,
Chiara Nitride, and Pasquale Ferranti 3.1 Introduction: What is Food
Allergy? 69 3.2 Food Allergy: Features and Boundaries of the Disease 70 3.3
Immunopathology of Food Allergy and Role of Proteomics 71 3.4
Identification of Food Allergy Epitopes 73 3.5 Expression Proteomics and
Functional Proteomics in Food Allergy 81 3.6 Identification of Allergens in
Transformed Products 85 3.7 Concluding Remarks 90 References 91 4
Examination of the Efficacy of Antioxidant Food Supplements Using Advanced
Proteomics Methods 101 Ashraf G. Madian, Elsa M. Janle, and Fred E. Regnier
4.1 Introduction 101 4.2 Methods for Studying the Efficacy of Antioxidants
102 4.3 Strategies Used for Proteomic Analysis of Carbonylated Proteins and
the Impact of Antioxidants 106 4.4 Studying Oxidation Mechanisms 107 4.5
Quantification of Carbonylation Sites 111 4.6 Biomedical Consequence of
Protein Oxidation and the Impact of Antioxidants 112 4.7 Redox Proteomics
and Testing the Efficacy of Antioxidants 113 References 117 5 Proteomics in
Food Science 125 Jose M. Gallardo, Monica Carrera, and Ignacio Ortea 5.1
Proteomics 125 5.2 Applications in Food Science 132 5.3 Species
Identification and Geographic Origin 132 5.4 Detection and Identification
of Spoilage and Pathogenic Microorganisms 140 5.5 Changes During Food
Storage and Processing and Their Relationship to Quality 144 5.6 Proteomics
Data Integration to Explore Food Metabolic Pathways and Physiological
Activity of Food Components 149 5.7 Nutriproteomics 150 5.8 Final
Considerations and Future Trends 151 References 152 6 Proteomics in
Nutritional Systems Biology: Defining Health 167 Martin Kussmann and
Laurent Fay 6.1 Introduction 167 6.2 From Food Proteins to Nutriproteomics
171 6.3 Nutritional Peptide and Protein Bioactives 172 6.4 Nutritional
Peptide and Protein Biomarkers 174 6.5 Ecosystem-Level Understanding of
Nutritional Host Health 178 6.6 Conclusions and Perspectives 181 References
182 7 MS-Based Methodologies for Transgenic Foods Development and
Characterization 191 Alberto Valdes and Virginia Garc?a-Canas 7.1
Introduction 191 7.2 Controversial Safety Aspects and Legislation on GMOs
192 7.3 Analysis of GMOs: Targeted Procedures and Profiling Methodologies
193 7.4 Conclusions and Future Outlook 212 Acknowledgments 212 References
212 8 MS-Based Methodologies to Study the Microbial Metabolome 221 Wendy R.
Russell and Sylvia H. Duncan 8.1 Introduction 221 8.2 The Gut Microbiota
and Their Role in Metabolism 222 8.3 Metagenomics 224 8.4 Metabolomics 225
8.5 Microbial Metabolites in the Human Gut 226 8.6 Analysis of the
Microbial Metabolome 229 8.7 Implications for Human Health and Disease 232
8.8 Summary 235 Acknowledgments 235 References 235 9 MS-Based Metabolomics
in Nutrition and Health Research 245 Clara Ibanez and Carolina Simó 9.1
Introduction 245 9.2 MS-Based Metabolomics Workflow 246 9.3 Metabolomics in
Nutrition-Related Studies 253 9.4 Diet/Nutrition and Disease: Metabolomics
Applications 259 9.5 Other Applications in Nutritional Metabolomics 261 9.6
Integration with Other "Omics" 262 9.7 Concluding Remarks 263
Acknowledgments 264 References 264 10 Shaping the Future of Personalized
Nutrition with Metabolomics 271 Max Scherer, Alastair Ross, Sofia Moco,
Sebastiano Collino, François-Pierre Martin, Jean-Philippe Godin, Peter
Kastenmayer, and Serge Rezzi 10.1 Introduction 271 10.2 Metabolomics
Technologies 272 10.3 Personalized Nutrition 278 10.4 Conclusion 291
References 292 11 How Does Foodomics Impact Optimal Nutrition? 303 Anna
Arola-Arnal, Josep M. del Bas, Antoni Caimari, Anna Crescenti, Francesc
Puiggros, Manuel Suarez, and Llu?s Arola 11.1 Introduction 303 11.2
Nutrigenomics 310 11.3 Nutrigenetics and Personalized Nutrition 323 11.4
The Added Value of Foodomics for the Food Industry 329 11.5 Concluding
Remarks 337 References 337 12 Lipidomics 351 Isabel Bondia-Pons and Tuulia
Hyotylainen 12.1 Definition and Analytical Challenges in Lipidomics 351
12.2 Lipidomics in Nutrition and Health Research 360 12.3 Lipidomics and
Food Science 368 12.4 Future Perspectives 371 References 372 13 Foodomics
Study of Micronutrients: The Case of Folates 381 Susan J. Duthie 13.1
Folates in the Diet 381 13.2 Folate and Human Health 383 13.3 Measuring
Folates in Human Biomonitoring 385 13.4 Folate and Colon Cancer:
Establishing Mechanisms of Genomic Instability Using a Combined Proteomic
and Functional Approach 387 13.5 Folate Deficiency and Abnormal DNA
Methylation: A Common Mechanism Linking Cancer and Atherosclerosis 394 13.6
Summary 397 Acknowledgments 399 References 399 14 Metabolomics Markers in
Acute and Endurance/Resistance Physical Activity: Effect of the Diet 405
Sonia Medina, Debora Villano, Jose Ignacio Gil, Cristina Garc?a-Viguera,
Federico Ferreres, and Angel Gil-Izquierdo 14.1 Introduction 405 14.2
Metabolomics Consequences of Physical Activity: Metabolites and
Physiological Pathways Affected 407 14.3 Metabolomics and Physical
Activity: Effect of the Diet 410 14.4 Concluding Remarks and Future
Perspectives 411 Acknowledgments 412 References 412 15 MS-Based Omics
Evaluation of Phenolic Compounds as Functional Ingredients 415 Debora
Villano, Sonia Medina, Jose Ignacio Gil, Cristina Garc?a-Viguera, Federico
Ferreres, Francisco A. Tomas-Barberan, and Angel Gil-Izquierdo 15.1
Introduction 415 15.2 Use of Metabolomics in Nutritional Trials 416 15.3
Statistic Tools in Nutritional Metabolomics 421 15.4 Metabolomics from
Clinical Trials after Intake of Polyphenol-Rich Foods 421 15.5 Human
Metabolome in Low and Normal Polyphenol Dietary Intake 424 15.6 Concluding
Remarks and Future Perspectives 424 Acknowledgments 425 References 425 16
Metabolomics of Diet-Related Diseases 429 Marcela A. Erazo, Antonia Garc?a,
Francisco J. Ruperez, and Coral Barbas 16.1 Introduction 429 16.2 Analysis
of the Metabolome: Metabolomics 431 16.3 Diet-Related Diseases 432
References 446 17 MS-Based Metabolomics Approaches for Food Safety,
Quality, and Traceability 453 Mar?a Castro-Puyana, Jose A. Mendiola, Elena
Ibanez, and Miguel Herrero 17.1 Introduction 453 17.2 MS-Based Metabolomics
for Food Safety 455 17.3 MS-Based Metabolomics to Assess Food Quality 462
17.4 MS-Based Metabolomics Strategies for Food Traceability 464 17.5
Conclusions and Future Outlook 467 Acknowledgments 468 References 468 18
Green Foodomics 471 Jose A. Mendiola, Mar?a Castro-Puyana, Miguel Herrero,
and Elena Ibanez 18.1 Basic Concepts of Foodomics (and How to Make it
Greener) 471 18.2 Basic Concepts of Green Chemistry 472 18.3 Green
Processes to Produce Functional Food Ingredients 476 18.4 Development of
Green Analytical Processes for Foodomics 482 18.5 Comparative LCA Study of
Green Analytical Techniques: Case Study 493 18.6 Conclusion 497
Acknowledgments 498 References 498 19 Chemometrics, Mass Spectrometry, and
Foodomics 507 Thomas Skov and Søren B. Engelsen 19.1 Foodomics Studies 507
19.2 XC-MS Data 511 19.3 Data Structures and Models 517 19.4 Conclusion 534
References 535 20 Systems Biology in Food and Nutrition Research 539 Matej
Oresic 20.1 Systems Biology--New Opportunity for Food and Nutrition
Research 539 20.2 Systems Approach to Identify Molecular Networks Behind
Health and Disease 542 20.3 Food Metabolome and its Effect on Host
Physiology 544 20.4 Building A Systems Biology Platform for Food and
Nutrition Research 545 20.5 Future Perspectives 546 References 547 Index
551