J. Christopher States

Arsenic (eBook, PDF)

Exposure Sources, Health Risks, and Mechanisms of Toxicity

• Format: PDF

Produktbeschreibung

This book illustrates the chemistry, toxicology, and health effects of arsenic using novel modeling techniques, case studies, experimental data, and future perspectives. * Covers exposure sources, health risks, and mechanisms of one of the most toxic minerals in the world * Helps readers understand potential health effects of arsenic, using population studies, mammalian and invertebrate models, and pharmacokinetic and toxicokinetic models * Discusses outcomes, epidemiology, real-life examples, and modes of action for arsenic-induced diseases, like lung cancer, diabetes, cardiovascular and pulmonary diseases, and immunotoxicity * Acts as a reference for toxicologists, environmental chemists, and risk assessors and includes up-to-date, novel modeling techniques for scientists * Includes future perspectives on special topics, like extrapolation from experimental models to human exposures, biomarkers for phenotypic anchoring, and pathology of chronic exposure

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 576
• Erscheinungstermin: 1. Oktober 2015
• Englisch
• ISBN-13: 9781118876596
• Artikelnr.: 43982395

Autorenporträt

J. Christopher States, PhD, is Professor, University Scholar and Vice Chair for Graduate Education in the Department of Pharmacology and Toxicology, and Associate Dean for Research in the University of Louisville School of Medicine, Louisville, Kentucky. He is a Past President of the Society of Toxicology Metals Specialty Section, on the editorial board of several leading journals, and regularly serves as a reviewer of manuscripts and National Institutes of Health grants. He has organized symposia and workshops and chaired sessions on arsenic exposure and toxicology at international conferences and published over 100 articles.

Inhaltsangabe

Section I: Fundamentals of Arsenic Exposure and Metabolism

Chapter 1: History of Arsenic as a Poison and Medicinal 4

Chapter 2: Geogenic and Anthropogenic Arsenic Hazard in Groundwaters and Soils - Distribution, Nature, Origin & Human Exposure Routes 34

Chapter 3: Remediation of Arsenic in Drinking Water 115

Chapter 4: The Chemistry and Metabolism of Arsenic 149

Section II: Epidemiology and Disease Manifestations of Arsenic Exposure

Chapter 5: Human Population Studies and Nutritional Intervention 203

Chapter 6: Skin manifestations of chronic arsenicosis 230

Chapter 7: Lung cancer and other pulmonary diseases 247

Chapter 8: Bladder Cancer and Arsenic 300

Chapter 9: Neurological Effects of Arsenic Exposure 342

Chapter 10: Diabetes Mellitus 387

Chapter 11: Hepatotoxicity 428

Chapter 12: Genetic Epidemiology of Susceptibility to Arsenic-induced Diseases 457

Section III. Mechanisms of Toxicity

Chapter 13: Arsenic Interaction with Zinc Finger Motifs 501

Chapter 14: Role In Chemotherapy 545

Chapter 15: Genotoxicity 607

Chapter 16: Arsenic and Signal Transduction 650

Chapter 17: Stem Cell Targeting and Alteration by Arsenic 704

Chapter 18: Epigenetics and Arsenic Toxicity 748

Section IV: Models for Arsenic Toxicology, Risk Assessment

Chapter 19: Cancer Induced by Exposure to Arsenicals in Animals 779

Chapter 20: Arsenic induced cardiovascular disease 804

Chapter 21: Invertebrate Models in Arsenic Research: Past, Present & Future 835

Chapter 22: Toxicokinetics and Pharmacokinetic Modelling of Arsenic 884

Chapter 23: Considerations for a Biologically Based Risk Assessment for Arsenic 909

Chapter 24: Translating experimental data to human populations 955