TOXIC METAL CHELATION
STRATEGIES TO DESIGN PEPTIDE CHELATORS FOR CARCINOGENIC METALS
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In today's scientific world, the peptide therapeutics has gained more attention due its safety, efficacy, selectivity and specificity. In this book the authors intended to describe the simple and significant key factors that have to be considered in designing effective peptide chelators for five carcinogenic metals. These factors were derived from observing the coordination geometry of metal within its coordination sphere in a protein. Data are derived from experimentally validated structures and hence the results presented are reliable and valid. The book provides a novel strategy by combinin...
In today's scientific world, the peptide therapeutics has gained more attention due its safety, efficacy, selectivity and specificity. In this book the authors intended to describe the simple and significant key factors that have to be considered in designing effective peptide chelators for five carcinogenic metals. These factors were derived from observing the coordination geometry of metal within its coordination sphere in a protein. Data are derived from experimentally validated structures and hence the results presented are reliable and valid. The book provides a novel strategy by combining coordination chemistry and biology in designing peptide chelates for bioremediation and therapeutic purposes.
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