A study on biologically potential heterocycles
Synthesis and bioassay of oxazoles, thiazoles, imidazoles, benzoxazoles, benzothiazoles and benzimidazoles
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Azoles and benzazoles represent an indispensable class of heteroaromatic compounds in the field of organic and medicinal chemistry. In fact, azoles derivatives are potential chemical entities as they are part of many biologically active pharmaceuticals vital for increasing the quality of life. It was well known that the combination of two or more different types of heterocycles in one molecule could yield a novel entity with enhanced biopotency to combat various diseases and pathophysiological conditions. Amide and sulfonamide containing heteroaromatics have attracted substantial attention due...
Azoles and benzazoles represent an indispensable class of heteroaromatic compounds in the field of organic and medicinal chemistry. In fact, azoles derivatives are potential chemical entities as they are part of many biologically active pharmaceuticals vital for increasing the quality of life. It was well known that the combination of two or more different types of heterocycles in one molecule could yield a novel entity with enhanced biopotency to combat various diseases and pathophysiological conditions. Amide and sulfonamide containing heteroaromatics have attracted substantial attention due to their broad spectrum of biological and therapeutic applications. The exploration of new molecules that can accommodate potency to multiple biological targets remains an intriguing scientific endeavor. Motivated by the biopotency of these structurally diversed heteroaromatics, simple substrates with different functionalities were explored for the synthesis of variety of heterocycles-azolylbenzazoles and pyrrolylazoles linked by sulfonamido acetamide moiety adopting simple, facile and elegant synthetic methodologies.
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