Virulence Regulation Mechanisms in Staphylococci
Virulence Regulation in Staphylococci
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Staphylococcus aureus is a Gram positive bacterium that is part of the normal flora, but can cause infections by producing toxins. These bacteria are common causes of bloodstream and other infections in hospitalized patients. Recently the frequency of antibiotic-resistant Staphylococci strains is increasing. It is thus, important to find new ways to prevent and to treat such infections. The production of toxins (virulence) is regulated by cell-cell communication (quorum sensing) through the secretion of an autoinducer protein termed RAP (RNAIII Activating Protein). RAP leads to upregulation of...
Staphylococcus aureus is a Gram positive bacterium
that is part of the normal flora, but can cause
infections by producing toxins. These bacteria are
common causes of bloodstream and other infections in
hospitalized patients. Recently the frequency of
antibiotic-resistant Staphylococci strains is
increasing. It is thus, important to find new ways
to prevent and to treat such infections. The
production of toxins (virulence) is regulated by
cell-cell communication (quorum sensing) through the
secretion of an autoinducer protein termed RAP
(RNAIII Activating Protein). RAP leads to
upregulation of the quorum sensing system termed agr
(Accessory Gene Regulator), leading to the
production of RNAIII, which increases the creation
of multiple toxins. This book reveals how virulence
is regulated by staphylococci. RAP appears to be an
autoinducer of virulence. The second inducer is
alcohol, an exogenic inducer to the system. The
novel findings in this book are useful to Doctors
and professionals in Medicine and Life Science or
anyone who may be interested in developing novel
therapeutics and creating new ways to prevent and
treat microorganisms' infections.
that is part of the normal flora, but can cause
infections by producing toxins. These bacteria are
common causes of bloodstream and other infections in
hospitalized patients. Recently the frequency of
antibiotic-resistant Staphylococci strains is
increasing. It is thus, important to find new ways
to prevent and to treat such infections. The
production of toxins (virulence) is regulated by
cell-cell communication (quorum sensing) through the
secretion of an autoinducer protein termed RAP
(RNAIII Activating Protein). RAP leads to
upregulation of the quorum sensing system termed agr
(Accessory Gene Regulator), leading to the
production of RNAIII, which increases the creation
of multiple toxins. This book reveals how virulence
is regulated by staphylococci. RAP appears to be an
autoinducer of virulence. The second inducer is
alcohol, an exogenic inducer to the system. The
novel findings in this book are useful to Doctors
and professionals in Medicine and Life Science or
anyone who may be interested in developing novel
therapeutics and creating new ways to prevent and
treat microorganisms' infections.
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