Computaional Design and Evaluation of Antibacterial agents
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Infectious disease remains as major health problem due to the rapid development of resistance to existing antibacterial drugs. The spread of resistance among Gram negative bacterial like Pseudomonas aeruginosa, increase the limitation in the in the availability of therapeutic. The purpose of this book is to present an update perspective upon the use of Quinoline-2-one derivative as antibacterial agents, as well as computational design and prediction the binding with target protein to enhancing their antibacterial efficacy, in order to highlight potential new solutions to cope with infections r...
Infectious disease remains as major health problem due to the rapid development of resistance to existing antibacterial drugs. The spread of resistance among Gram negative bacterial like Pseudomonas aeruginosa, increase the limitation in the in the availability of therapeutic. The purpose of this book is to present an update perspective upon the use of Quinoline-2-one derivative as antibacterial agents, as well as computational design and prediction the binding with target protein to enhancing their antibacterial efficacy, in order to highlight potential new solutions to cope with infections resulting from drug-resistance bacteria. The Quinoline-2-one derivatives that designed and synthesized in this study presented novel and promising antibacterial agents, which bind with target protein (DNA gyrase) and maintained the cleavage complex with DNA and being lethal to bacteria. Design and evaluation of antibacterial activity of Quinoline-2-one derivatives opening new directions in drug discovery process.
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