• Produktbild: The Reticuloendothelial System
  • Produktbild: The Reticuloendothelial System

The Reticuloendothelial System A Comprehensive Treatise Volume 5 Cancer

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Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

22.03.2012

Herausgeber

Herman Friedman

Verlag

Springer Us

Seitenzahl

356

Maße (L/B/H)

25,4/17,8/2,1 cm

Gewicht

713 g

Auflage

Softcover reprint of the original 1st ed. 1983

Sprache

Englisch

ISBN

978-1-4684-4510-7

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

22.03.2012

Herausgeber

Herman Friedman

Verlag

Springer Us

Seitenzahl

356

Maße (L/B/H)

25,4/17,8/2,1 cm

Gewicht

713 g

Auflage

Softcover reprint of the original 1st ed. 1983

Sprache

Englisch

ISBN

978-1-4684-4510-7

Herstelleradresse

Springer-Verlag GmbH
Tiergartenstr. 17
69121 Heidelberg
DE

Email: [email protected]

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  • Produktbild: The Reticuloendothelial System
  • Produktbild: The Reticuloendothelial System
  • 1. Neoplasms of the Mononuclear Phagocyte System.- 1. Acute Myelomonocytic Leukemia (AMML, French-American-British Classification, FAB-M4).- 2. Acute Monocytic Leukemia (AMoL, FAB-M5).- 3. Chronic Myelomonocytic Leukemia (CMML).- 4. Malignant Histiocytoses, without Langerhans Granules.- 4.1. Histiocytic Medullary Reticulosis.- 4.2. Malignant Histiocytoses, Not Otherwise Specified.- 5. Malignant Histiocytoses, with Langerhans Granules.- 6. Proliferations of MPS, Not Proven to Be Malignant Neoplasms.- 6.1. Histiocytoses of Cells without Langerhans Granules.- 6.2. Histiocytoses of Cells with Langerhans Granules.- 7. Other Neoplasms Considered to Be of MPS Origin.- 8. Differential Diagnosis.- References.- 2. Lymphatic Metastasis of Neoplasms.- 1. Lymph Node Metastasis in Human Cancer.- 2. Invasion and Metastasis.- 3. The Normal Lymphatic Vessel and Its Cellular Content.- 4. Experimental Lymphatic Metastasis.- 5. Penetration of the Lymphatic Capillary.- 6. Cells in Lymph-Draining Tumors.- 7. Reaction in the Draining Node.- 8. Barrier Function of Lymph Nodes—Tumor Cell Killing.- 9. Chemotherapy and Immunotherapy of Lymphatic Metastasis.- References.- 3. Control of Tumors by the RES.- 1. Introduction.- 1.1. Local and Host Factors in Resistance to Cancer.- 1.2. Involvement of the RES in Cancer: Supportive Evidence.- 1.3. Interactions between the RES and Cancer.- 2. The RES in Development of Cancer.- 2.1. Functional Parameters.- 2.2. Genetic Determinants of RE Functions.- 2.3. Specific Models of Carcinogenesis.- 2.4. Comments.- 3. The RES in Progression of Cancer.- 3.1. Morphologic Features.- 3.2. Functional Changes in the Cancer Host.- 3.3. Macrophages in Tumors.- 3.4. Effects of Macrophages on Metastatic Dissemination.- 3.5. Comments.- 4. Mechanisms Mediating Antineoplastic Activity of the RES.- 4.1. Participation in Immune Responses.- 4.2. Activation of Macrophages: Cytostatic and Cytocidal Macrophages.- 4.3. Regulation of Growth.- 4.4. Comments.- 5. Factors Affecting Antineoplastic Activities of the RES.- 5.1. Heterogeneity of Macrophages.- 5.2. Humoral Factors (Opsonins).- 5.3. Hormones.- 5.4. Nutrition.- 5.5. Macromolecules.- 5.6. Microbial Agents.- 5.7. Comments.- 6. Modulation of the RES and Cancer.- 6.1. Stimulation of the RES.- 6.2. Depression of the RES.- 6.3. Subversion of the RES by Cancer.- 7. The RES and the Concept of Immune Surveillance.- 8. Conclusions.- References.- 4. Activities of Macrophages Within and Peripheral to the Tumor Mass.- 1. Introduction.- 2. Mechanisms Controlling Accumulation of TAM.- 3. Peripheral Blood Monocytes, TAM, and Heterogeneity.- 3.1. Macrophage Heterogeneity.- 4. Tumor Immunogenicity, Host Immunity, and TAM.- 5. Macrophages and Intratumor Functions.- 5.1. Macrophage-Mediated Cytolosis or Cytostasis.- 5.2. Antibody-Dependent Cytotoxicity.- 5.3. Stimulation of Tumor Growth.- 5.4. Involvement in Therapy.- 5.5. TAM and Induction of Immunity.- 5.6. Other Functions of TAM in situ.- 6. Conclusions.- References.- 5. Stimulation of the RES and Control of Cancer Metastasis.- 1. The Pathogenesis of Cancer Metastasis.- 2. Host Immunity and Metastasis.- 3. Rationale for Control of Micrometastasis by Activated Cytotoxic Macrophages.- 4. Activation of Macrophages by Agents Encapsulated within Liposomes.- References.- 6. Neoplasia and Mononuclear Phagocyte Function.- 1. Introduction.- 2. Role of Macrophages in Tumor Growth.- 3. Increase in Monocyte/Macrophage Numbers in Tumor-Bearing Animals.- 4. Enhancement of Macrophage Migration by Tumor Factors.- 5. Chemotactic Factor Inactivators Associated with Neoplasia.- 6. Monocyte/Macrophage Migratory Dysfunction in Tumor-Bearing Hosts: Evidence for the Presence of Tumor-Associated Inhibitory Factors.- 7. Isolation and Characterization of Inhibitors of Mononuclear Phagocyte Function Associated with Neoplasia.- 8. Summary.- References.- 7. Suppressor Cells and Cancer: Inhibition of Immune Functions by Macrophages.- 1. Introduction.- 2. Approaches for the Demonstration of Suppressor Macrophages.- 3. Suppression of Lymphoproliferative Responses.- 3.1. Tumor-Bearing Mice.- 3.2. Suppression of Proliferative Responses in Other Experimental Tumor Systems.- 3.3. Suppressor Cells in Humans.- 4. Suppression of the Generation of Cytotoxic T Lymphocytes.- 5. Suppression of Antibody Responses.- 6. Suppression of Lymphokine Production.- 7. Suppression of NK Cell Activity.- 8. Suppressor Macrophages in Normal as Well as in Tumor-Bearing Individuals.- 9. Do Macrophages Inhibit Every Aspect of the Immune Response?.- 10. Generation of Suppressor Macrophages.- 11. In Vivo Role of Suppressor Macrophages.- 12. Summary and Concluding Remarks.- References.- 8. Modulation of Mononuclear Phagocytes by Cancer Chemotherapeutic Agents.- 1. Introduction.- 2. Effects of Chemotherapeutic Agents on Mononuclear Phagocytes.- 2.1. Glucocorticoids.- 2.2. Antimetabolites.- 2.3. Alkylating Agents.- 2.4. Intercalating Agents.- 2.5. Plant Alkaloids.- 3. Antitumor Efficacy and Modulation of Mononuclear Phagocytes.- 4. Concluding Remarks.- References.- 9. Natural Killer Cells and Other Effector Cells, and Their Roles in Resistance against Cancer.- 1. Introduction.- 2. Effector Mechanisms That May Be Involved in Resistance against Tumor Growth.- 2.1. Tumor-Associated Antigens and Their Recognition by T and B Cells.- 2.2. Macrophages and Polymorphonuclear Leukocytes.- 2.3. NK Cells.- 3. Is the Immune Surveillance Hypothesis Valid?.- 3.1. Possible Role of Macrophages in Immune Surveillance.- 3.2. Possible Role of NK Cells or Other Related Natural Effector Cells in Immune Surveillance.- 3.3. Possible Role of ADCC in Immune Surveillance.- 4. Use of Assays for Monitoring of Immunotherapy Trials.- 5. Concluding Remarks.- References.- 10. Immunosuppressive Factors Produced by Tumors and Their Effects on the RES.- 1. Tumor-Produced Suppressor Factors.- 2. Blocking Factors—Immune Complexes.- 3. Tumor and Fetal Tissue Antigens.- 4. Plasma/Serum Factors.- 5. Tumor-Derived Suppressive Factors.- 6. Mastocytoma.- 7. Plasmacytoma.- 8. Factors from Chemically Induced Tumors.- 9. L1210 Leukemias.- 10. Tumor Cell Lines.- 11. Conclusions and Discussion.- 12. Summary.- References.- 11. Tumorigenic Virues Affecting the RES.- 1. Avian Virus-Induced Tumors of the RES.- 1.1. Avian RNA Viruses.- 1.2. Marek’s Disease.- 2. Virus-Induced Tumors of the RES in Mammals.- 2.1. Murine Leukemia-Sarcoma Virus Complex.- 2.2. DNA Viruses.- 3. Implications for Human Malignancies.- References.