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Solid Phase Organic Syntheses
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Lesern der renommierten Reihe 'Organic Syntheses' wird dieser Band sofort vertraut vorkommen: Ähnlich gestaltet und organisiert, bietet diese neue, jährlich aktualisierte Reihe Informationen zu Synthesen in fester Phase, die angesichts des enormen Aufschwungs der kombinatorischen Chemie ständig an Bedeutung gewinnen. Ebenfalls am großem Vorbild orientiert sich das Werk hinsichtlich der Akkuratesse: Alle besprochenen Syntheseverfahren wurden geprüft!
The rapid expansion of combinatorial chemistry has renewed interest in solid-phase organic synthesis, a method that lends itself well to creating and screening large numbers of lead compounds. Solid-Phase Organic Syntheses, Volume 1 is the first volume in a series that will be updated annually, filling a gap in the existing chemical literature. Providing information previously unavailable from a single resource, this series is dedicated to providing researchers in the field with validated and tested methods for the solid-phase synthesis of interesting and biologically relevant molecules.Solid-phase methods will virtually always be invented for application in combinatorial organicsynthesis. To meet these specific needs, Solid-Phase Organic Syntheses, Volume 1 focuses on a single type of synthetic transformation accomplished on solid support, and indicates how procedures are optimized to work with a structurally-wide variety of reagents. Written by recognized leaders in the field who review and test all chemical protocols before publication, organic transformations are organized by type of compound synthesized and reaction type.For the first time, experimental details for proven solid-phase synthetic molecules are collected in a single, invaluable resource. Solid-Phase Organic Syntheses, Volume 1 provides combinatorial chemists and researchers in organic chemistry and medicinal chemistry with the tools and descriptive protocols to achieve syntheses of desired compounds using a variety of solid supports and reagents.